The Human–Nature Relationship and Its Impact on Health: A Critical Review

Within the past four decades, research has been increasingly drawn toward understanding whether there is a link between the changing human–nature relationship and its impact on people’s health. However, to examine whether there is a link requires research of its breadth and underlying mechanisms from an interdisciplinary approach. This article begins by reviewing the debates concerning the human–nature relationship, which are then critiqued and redefined from an interdisciplinary perspective. The concept and chronological history of “health” is then explored, based on the World Health Organization’s definition. Combining these concepts, the human–nature relationship and its impact on human’s health are then explored through a developing conceptual model. It is argued that using an interdisciplinary perspective can facilitate a deeper understanding of the complexities involved for attaining optimal health at the human–environmental interface

An investigation into the production of glycerol biofuel from microalgae in South Africa.

M. Sc. University of KwaZulu-Natal, Durban 2013.Energy provision in South Africa is going through great changes in this first half of the 21ˢᵗ century. Ensuring delivery of electricity to all households within the country, along with continued industrial growth, has left the national electricity provider and distributor, Eskom, with insufficient capacity. Understanding of environmental and health issues related to traditional energy generation methods, along with local and international political pressure has moved the South African Government to commit to long-term energy-efficiency and renewable energy targets. In recent years the door has begun to open to foreign and private investment on the energy-supply side. At the same time, the efficiency and price of alternative renewable energy sources has significantly improved, as global investments continue to rise. Confidence in the reliability of these technologies has risen, as developed countries demonstrate greater dependence on them, and prove that they can compete with traditional fossil fuels. This is further improved as a financial cost looms on the existing environmental and health costs associated with carbon dioxide and other greenhouse gas emissions. The use of microalgae to produce stable, transportable liquid fuels at greater efficiencies than traditional biofuels, in open ponds is investigated here. For the purpose of this study the microalgae Dunaliella salina producing glycerol as a biofuel is used, but the results could apply universally to the use of open raceway ponds. Geographic Information System analysis of the maximum and minimum temperature ranges, rainfall and solar irradiance shows that 11.3% of South Africa is well suited to this technology. Mapping of the 59 biggest emitters of carbon dioxide in South Africa reveal that 5 are located within this area, and within 500 m of a major river. Despite the great variation of external factors across South Africa, the results of this study show great promise for this type of renewable technology.Dr Helen Watson is acknowledged for her her role in this project

Air Quality Health Benefits of the Nevada Renewable Portfolio Standard

In recent years, renewable portfolio standards (RPS), which require a certain percentage of electricity sold to consumers to come from renewable resources, have been established by many state governments to mitigate emissions of greenhouse gases and air pollutants in the United States. Nevada’s RPS set a target of 50% of electricity to come from renewable sources by 2030. By coupling the U.S. Environmental Protection Agency’s AVoided Emissions and geneRation Tool (AVERT) and CO–Benefits Risk Assessment (COBRA) model, this study assesses potential emission reductions from fossil fuels owing to this requirement and regional health benefits via improved air quality, as well as how these benefits vary spatially under high and low projected electricity demands in 2030. Successful implementation of the RPS could produce health benefits equivalent to USD 3–8 million per year for Nevada residents and up to USD 164 million per year for the entire U.S. Nevada is ranked only 6th among states benefiting from the policy, while California and Washington obtain the most health benefits. There is also inequity among Nevada counties, partly caused by the county population and proximity to major fossil fuel power plants. Lowering electricity demands by 5% in Nevada would lead to a ~10% increase in health benefits. These findings should empower public support of RPS policies and energy conservation to reduce air pollution and public health inequity for the region

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

A computational framework for modeling grain structure development in three dimensions

August 2007School of EngineeringPh

Robust evidence for random fractal scaling of groundwater levels in unconfined aquifers

This study introduces new approaches to improve the statistical robustness of techniques for quantifying the fractal scaling of groundwater levels, and uses these techniques to investigate scaling of groundwater levels from a consolidated permeable carbonate aquifer. Six groundwater level time series and an associated river stage time series from the unconfined Chalk aquifer (a dual-porosity, fractured limestone aquifer) in the Pang–Lambourn catchment, UK, have been analysed. Surrogate data of time series with known scaling properties have been used to estimate the probability distribution of the spectral and geometric scaling exponents determined by detrended fluctuation analysis (DFA) and power spectral density (PSD) respectively; robust regression techniques have been used to improve estimates of the scaling exponents; and robust non-parametric techniques have been used to correlate scaling exponents with features of the boreholes and catchments. Strong statistical support has been found for temporal scaling of groundwater levels over a wide range of time scales, however, bootstrap estimates of the scaling exponents indicate a much larger range of exponents than found by previous studies, suggesting that the uncertainty in existing estimates of scaling exponents may be too small. There is robust evidence that geometrical scaling properties at each borehole can be related to the depth of the observation boreholes and distance of those boreholes from the river in the catchment, but no such correlations were found for the spectral scaling exponents. The results build on the body of evidence that groundwater levels, as with many hydrogeological phenomena, may be well modelled with mathematical concepts from statistical mechanics that do not attempt to capture every detail of these highly heterogeneous and complex systems