3,190 research outputs found

    Managing networks as learning organizations in the public sector

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    This paper addresses the increasing use of network forms of governance and the challenges would-be network managers confront, including the persistent need network structures create to secure a modicum of internal goal alignment among participating members, the difficulty of establishing and maintaining trust among collaborating organizational representatives, and the problematic of ensuring alignment of internal and external accountability claims in inter-organizational and often multi-sectoral collaboratives. The paper reviews the literature and discusses the significance of communication management within network arrangements, including the role of technology for effective communication and subsequent coordination efforts. It concludes by arguing that networks are de facto distributed environments and working across them requires developing learning strategies to enhance member capacities to work collaboratively to address common concerns

    Identification of T-cell receptor a-chain genes in the chicken

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    T-cell receptor (TCR) -chain (TCR) and ß-chain (TCRß) genes are well characterized in mammals, while only TCRß genes have been identified in other vertebrates. To identify avian TCR genes, we used monoclonal anti-CD3 antibodies to isolate chicken TCR for peptide sequence analysis. Degenerate oligonucleotide probes were then used to isolate a candidate TCR cDNA clone that hybridized with a 1.7-kb mRNA species present only in ß T cells and in tissues populated by these cells. Southern blot analysis revealed gene rearrangement in thymocytes and ß T-cell lines. The TCR cDNA candidate encoded an openreading frame of 275 amino acids, the predicted variable (V)-, joining (J)-, and constant (C)-region amino acid sequences of which shared 40%, 60%, and 25% homology with corresponding mammalian sequences. A single C gene and 25 V genes were identified by using region-specific probes. The V cDNA probe isolated from a Vß1+ cell line reacted with transcripts from one of five Vß2+ cell lines, suggesting shared use of V genes by Vß1+ and Vß2+ T cells and the existence of other V gene families. A genomic V sequence was flanked by classical recombination signal sequences but, unlike previously defined V genes, the leader and V region were encoded by a single exon. The data indicate evolutionary conservation of the basic TCR gene structure in birds and mammal

    Identification of a Candidate CD5 Homologue in the Amphibian Xenopus laevis

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    We identified a novel T cell Ag in the South African clawed toad (Xenopus laevis) by a mAb designated 2B1. This Ag is present in relatively high levels on most thymocytes, approximately 65% of splenocytes, 55% of PBL, and 65% of intestinal lymphocytes, but is rarely seen on IgM+ B cells in any of these tissues. Lymphocytes bearing the 2B1 Ag proliferate in response to stimulation with Con A or PHA, whereas the 2B1- lymphocytes are reactive to LPS. Biochemical analysis indicates that this Ag is a differentially phosphorylated glycoprotein of 71 to 82 kDa. The protein core of 64 kDa bears both N- and O-linked carbohydrate side chains. The amino-terminal protein sequence of the 2B1 Ag shares significant homology with both the macrophage scavenger receptor type 1 motif and the mammalian CD5/CD6 family. The biochemical characteristics and cellular distribution of the 2B1 Ag suggest that it represents the CD5 homologue in X. laevis. While T cells constitutively express this highly conserved molecule, Xenopus B cells acquire the CD5 homologue only when they are stimulated in the presence of T cell

    Morphologies of Galaxies in and around a Protocluster at z=2.300

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    We present results from the first robust investigation of galaxy morphology as a function of environment at z>1.5. Our study is motivated by the fact that star-forming galaxies contained within a protocluster at z=2.3 in the HS1700+64 field have significantly older ages and larger stellar masses on average than those at similar redshifts but more typical environmental densities. In the analysis of HST/ACS images, we apply non-parametric statistics to characterize the rest-frame UV morphologies of a sample of 85 UV-selected star-forming galaxies at z=1.7-2.9, 22 of which are contained in the protocluster. The remaining 63 control-sample galaxies are not in the protocluster but have a similar mean redshift of ~2.3. We find no environmental dependence for the distributions of morphological properties. Combining the measured morphologies with the results of population synthesis modeling, we find only weak correlations, if any, between morphological and stellar population properties such as stellar mass, age, extinction and star-formation rate. Given the incomplete census of the protocluster galaxy population, and the lack of correlation between rest-frame UV morphology and star-formation history at z~2 within our sample, the absence of environmental trends in the distribution of morphological properties is not surprising. Additionally, using a larger sample of photometric candidates, we compare morphological distributions for 282 UV-selected and 43 near-IR-selected galaxies. While the difference in the degree of nebulosity between the two samples appears to be a byproduct of the fainter average rest-frame UV surface brightness of the near-IR-selected galaxies, we find that, among the lowest surface brightness galaxies, the near-IR-selected objects have significantly smaller angular sizes (abridged).Comment: 25 pages including 16 figures. Accepted for publication in ApJ. Version with full resolution figures available at http://www.astro.princeton.edu/~apeter/LBG/papers/peter2007_fullres.ps.g

    Apparent wave function collapse caused by scattering

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    Some experimental implications of the recent progress on wave function collapse are calculated. Exact results are derived for the center-of-mass wave function collapse caused by random scatterings and applied to a range of specific examples. The results show that recently proposed experiments to measure the GRW effect are likely to fail, since the effect of naturally occurring scatterings is of the same form as the GRW effect but generally much stronger. The same goes for attempts to measure the collapse caused by quantum gravity as suggested by Hawking and others. The results also indicate that macroscopic systems tend to be found in states with (Delta-x)(Delta-p) = hbar/sqrt(2), but microscopic systems in highly tiltedly squeezed states with (Delta-x)(Delta-p) >> hbar.Comment: Final published version. 20 pages, Plain TeX, no figures. Online at http://astro.berkeley.edu/~max/collapse.html (faster from the US), from http://www.mpa-garching.mpg.de/~max/collapse.html (faster from Europe) or from [email protected]

    Verification of Post-glacial Speleogenesis and the Origins of Epigene Maze Caves in New York

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    Dissolutional features called karst exist on the surface, and in the subsurface as caves. In glaciated regions caves were thought to be post-glacial in origin. Work in the 1970s demonstrated that pre-glacial caves existed, but did not answer if a cave could form post-glacially. A model proposed by Mylroie and Carew (1987) states that a post-glacial cave would be controlled entirely by glacial features and the deranged drainage of glaciated terrains. Caves known as maze caves form at maximum rates, and could form to navigable size in the time since deglaciation. Maze caves form in the shallow subsurface, allowing them to be removed in subsequent glaciations. GIS water flow analysis, and calculation of formation times using cross-section data demonstrates that maze caves in the glaciated region of New York are post-glacial in origin fitting in the deranged drainage and forming in the time since deglaciation

    Does the universe in fact contain almost no information?

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    At first sight, an accurate description of the state of the universe appears to require a mind-bogglingly large and perhaps even infinite amount of information, even if we restrict our attention to a small subsystem such as a rabbit. In this paper, it is suggested that most of this information is merely apparent, as seen from our subjective viewpoints, and that the algorithmic information content of the universe as a whole is close to zero. It is argued that if the Schr\"odinger equation is universally valid, then decoherence together with the standard chaotic behavior of certain non-linear systems will make the universe appear extremely complex to any self-aware subsets that happen to inhabit it now, even if it was in a quite simple state shortly after the big bang. For instance, gravitational instability would amplify the microscopic primordial density fluctuations that are required by the Heisenberg uncertainty principle into quite macroscopic inhomogeneities, forcing the current wavefunction of the universe to contain such Byzantine superpositions as our planet being in many macroscopically different places at once. Since decoherence bars us from experiencing more than one macroscopic reality, we would see seemingly complex constellations of stars etc, even if the initial wavefunction of the universe was perfectly homogeneous and isotropic.Comment: 17 pages, LATeX, no figures. Online with refs at http://astro.berkeley.edu/~max/nihilo.html (faster from the US), from http://www.mpa-garching.mpg.de/~max/nihilo.html (faster from Europe) or from [email protected]
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