1,079 research outputs found
An Analysis of Accounting Principles: A Case Study on 3D Systems Corporation
This anthology of cases was completed during my junior year at the University of Mississippi. Working both in a group and individually, I conducted research on various topics related to the accounting profession and how they relate to 3D Systems Corporation and its financials. I spoke through the findings with accounting professionals on a regular basis, and at the end of the semester defended those results to my classmates and professionals in a final presentation
Smooth Muscle-Generated Methylglyoxal Impairs Endothelial Cell-Mediated Vasodilatation of Cerebral Microvessels in Type 1 Diabetic Rats
Background and Purpose
Endothelial cell-mediated vasodilatation of cerebral arterioles is impaired in individuals with Type 1 diabetes (T1D). This defect compromises haemodynamics and can lead to hypoxia, microbleeds, inflammation and exaggerated ischaemia-reperfusion injuries. The molecular causes for dysregulation of cerebral microvascular endothelial cells (cECs) in T1D remains poorly defined. This study tests the hypothesis that cECs dysregulation in T1D is triggered by increased generation of the mitochondrial toxin, methylglyoxal, by smooth muscle cells in cerebral arterioles (cSMCs).
Experimental Approach
Endothelial cell-mediated vasodilatation, vascular transcytosis inflammation, hypoxia and ischaemia-reperfusion injury were assessed in brains of male Sprague-Dawley rats with streptozotocin-induced diabetes and compared with those in diabetic rats with increased expression of methylglyoxal-degrading enzyme glyoxalase-I (Glo-I) in cSMCs.
Key Results
After 7–8 weeks of T1D, endothelial cell-mediated vasodilatation of cerebral arterioles was impaired. Microvascular leakage, gliosis, macrophage/neutrophil infiltration, NF-κB activity and TNF-α levels were increased, and density of perfused microvessels was reduced. Transient occlusion of a mid-cerebral artery exacerbated ischaemia-reperfusion injury. In cSMCs, Glo-I protein was decreased, and the methylglyoxal-synthesizing enzyme, vascular adhesion protein 1 (VAP-1) and methylglyoxal were increased. Restoring Glo-I protein in cSMCs of diabetic rats to control levels via gene transfer, blunted VAP-1 and methylglyoxal increases, cECs dysfunction, microvascular leakage, inflammation, ischaemia-reperfusion injury and increased microvessel perfusion.
Conclusions and Implications
Methylglyoxal generated by cSMCs induced cECs dysfunction, inflammation, hypoxia and exaggerated ischaemia-reperfusion injury in diabetic rats. Lowering methylglyoxal produced by cSMCs may be a viable therapeutic strategy to preserve cECs function and blunt deleterious downstream consequences in T1D
A Survey of How English Language Arts Teachers Address Synthesis Writing in Classroom Instruction
The use of information from source materials in service of an argument or idea original to a writer is, according to the scholarly literature, one of the most complex applications of reading and writing. It is also, according to the literature, a type of composition that is valued in higher education. In an effort to determine how teachers of various English Language Arts (ELA) courses are addressing this important type of writing, the author conducted a nationwide survey, collecting responses from 1,200 ELA teachers. The survey asked respondents to provide a definition of synthesis writing and to describe an example of a synthesis task that they would assign to students, and those definitions and task descriptions were categorized and coded. The survey also asked about the frequency with which respondents assign such synthesis-writing tasks, as well as the frequency with which they address key synthesis-writing strategies and with which they apply particular pedagogical strategies. Additionally, the survey asked respondents about their awareness of learning objectives pertaining to synthesis writing in their state course-of-study standards and the extent to which they received training on synthesis writing in college courses, professional development workshops, or in-service activities. Responses to these questions were analyzed against various demographic data provided by the respondents (e.g., type of ELA course taught, type of school, years of teaching experience) in order to determine if responses about synthesis writing correlated strongly with or were dependent on specific demographics.
The survey data suggest that respondents across various types of ELA courses define synthesis writing differently. Furthermore, respondents often perceive synthesis writing differently than their articulated definition of synthesis writing. Additionally, the types of tasks that they identify as synthesis writing often do not align with their own definitions of that term. The data also suggest that ELA teachers in urban schools or those whose students are primarily nonwhite may provide more frequent opportunities for what they perceive as synthesis-writing tasks, but those tasks are less likely to actually involve synthesis of information from multiple source materials. The data also indicate that ELA teachers with 16 or more years of teaching experience are more likely to provide frequent instruction in key synthesis-writing skills
The Idea of Music in "Out of the Cradle Endlessly Rocking"
Reads Whitman\u27s "Out of the Cradle Endlessly Rocking" in terms of the poem\u27s indebtedness to music, especially Italian Opera, arguing that music plays "not only a structural role, but a symbolic one," and that the "solution (\u27clew\u27) to the ultimate mystery of being is, for Whitman, an essentially musical solution.
The Idea of Music in "Out of the Cradle Endlessly Rocking"
Reads Whitman\u27s "Out of the Cradle Endlessly Rocking" in terms of the poem\u27s indebtedness to music, especially Italian Opera, arguing that music plays "not only a structural role, but a symbolic one," and that the "solution (\u27clew\u27) to the ultimate mystery of being is, for Whitman, an essentially musical solution.
Interferometric inverse synthetic aperture radar experiment using an interferometric linear frequency modulated continuous wave millimetre-wave radar
D. Felguera-Martín,1 J.-T. González-Partida,1 P. Almorox-González,1 M. Burgos-García,1 and B.-P. Dorta-Naranjo2
1Universidad Politécnica de Madrid, Ciudad Universitaria s/n, Grupo de Microondas y Radar. Departamento de Señales, Sistemas y Radiocomunicaciones, Madrid, Spain
2Universidad de Las Palmas de Gran Canaria, Departamento de Señales y Comunicaciones, Las Palmas de Gran Canaria, Spain
An interferometric linear frequency modulated continuous wave (LFMCW) millimetre-wave radar is presented, along with the results of an experiment conducted to study the feasibility of using it in a future millimetre-wave interferometric inverse synthetic aperture radar (InISAR) system. First, a description of the radar is given. Then, the signal processing chain is described, with special attention to the phase unwrapping technique. The interferometric phase is obtained by unwrapping the prominent target's phase in each antenna using a sliding frame processing technique. Cell migration issues in this method are also addressed. Simulations were carried out to illustrate and assess the processing chain and to show the effects of multipath echoes on the height measurement. In the real experiment, the range, speed and height of a moving target were tracked over consecutive inverse synthetic aperture radar (ISAR) image frames, verifying the performance of the whole system
An analysis of the effects of non-zero bandwidths on the second order nonlinear optical interactions
Nonzero bandwidth effects on second order nonlinear optical interactions with submillimeter wavelength application
A Study Of Medium And High Internal Phase Ratio Water/polymer Emulsions
Medium and high internal phase ratio water/polymer emulsions were studied utilizing scanning electron microscope techniques. Results are reported for the geometry and distribution of droplets for water/polymer ratios from 1 1 to 9 1. Electron micrographs confirm those models which predicts polyhedral droplet formation at high internal phase ratios. © 1973
- …
