Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice

Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides derived from tumor antigens many of which have since been used in clinical trials with varying degrees of success. Although these models are not perfect, they nonetheless allow transplantable tumor models to be developed to evaluate novel vaccination strategies that can then be applied in humans. In addition animals that have been genetically modified to “spontaneously” generate tumors that will grow within their correct environment are of greater value for studying angiogenesis, metastasis and the relationship between the immune system and tumor in a physiological setting. In this review, mice genetically modified to express HLA genes or to spontaneously develop tumors are discussed, highlighting their advantages and limitations as preclinical models for cancer immunotherapy

A Private Sector Perspective on the Celtic Tiger Experience

International Relations/Trade,

Player violence or violent players? Vicarious liability for sports participants

This article analyses two recent English cases concerning the law on vicarious liability for acts of violence and considers their significance in respect of on-field acts of violence in contact sports. It provides an overview of how the law of negligence has developed in the specific context of sports injuries (including the application of the defence of volenti) and critiques the application of vicarious liability to sports cases. This is followed by a consideration of the wider law on vicarious liability for violent employees through a review of Lister v Hesley Hall Ltd [2001] UKHL 22 and a deeper consideration of Mattis v Pollock [2003] EWCA Civ 887. The article continues with an analysis of how those decisions have changed the legal landscape in respect of violent sports participants, looking in particular at reported cases from three jurisdictions in which that issue has been raised

Test stand performance of a convertible engine for advanced V/STOL and rotorcraft propulsion

A variable inlet guide vane (VIGV) convertible engine that could be used to power future high-speed V/STOL and rotorcraft was tested on an outdoor stand. The engine ran stably and smoothly in the turbofan, turboshaft, and dual (combined fan and shaft) power modes. In the turbofan mode with the VIGV open, fuel consumption was comparable to that of a conventional turbofan engine. In the turboshaft mode with the VIGV closed, fuel consumption was higher than that of present turboshaft engines because power was wasted in churning fan-tip air flow. In dynamic performance tests with a specially built digital engine control and using a waterbrake dynamometer for shaft load, the engine responded effectively to large steps in thrust command and shaft torque

Outdoor test stand performance of a convertible engine with variable inlet guide vanes for advanced rotorcraft propulsion

A variable inlet guide van (VIGV) type convertible engine that could be used to power future high-speed rotorcraft was tested on an outdoor stand. The engine ran stably and smoothly in the turbofan, turboshaft, and dual (combined fan and shaft) power modes. In the turbofan mode with the VIGV open fuel consumption was comparable to that of a conventional turbofan engine. In the turboshaft mode with the VIGV closed fuel consumption was higher than that of present turboshaft engines because power was wasted in churning fan-tip airflow. In dynamic performance tests with a specially built digital engine control and using a waterbrake dynamometer for shaft load, the engine responded effectively to large steps in thrust command and shaft torque. Previous mission analyses of a conceptual X-wing rotorcraft capable of 400-knot cruise speed were revised to account for more fan-tip churning power loss than was originally estimated. The new calculations confirm that using convertible engines rather than separate lift and cruise engines would result in a smaller, lighter craft with lower fuel use and direct operating cost

Experimental performance of a ventral nozzle with pitch and yaw vectoring capability for SSTOVL aircraft

Aircraft with supersonic, short takeoff, and vertical landing capability were proposed to replace some of the current high-performance aircraft. Several of these configurations use a ventral nozzle in the lower fuselage, aft of the center of gravity, for lift or pitch control. Internal vanes canted at 20 deg were added to a swivel-type ventral nozzle and tested at tailpipe-to-ambient pressure ratios up to 5.0 on the Powered Lift Facility at NASA LeRC. The addition of sets of four and seven vanes decreased the discharge coefficient by at least 6 percent and did not affect the thrust coefficient. Side force produced by the nozzle with vanes was 14 percent or more of the vertical force. In addition, this side force caused only a small loss in vertical force in comparison to the nozzle without vanes. The net thrust force was 8 deg from the vertical for four vanes and 10.5 deg for seven

Performance characteristics of a one-third-scale, vectorable ventral nozzle for SSTOVL aircraft

Several proposed configurations for supersonic short takeoff, vertical landing aircraft will require one or more ventral nozzles for lift and pitch control. The swivel nozzle is one possible ventral nozzle configuration. A swivel nozzle (approximately one-third scale) was built and tested on a generic model tailpipe. This nozzle was capable of vectoring the flow up to + or - 23 deg from the vertical position. Steady-state performance data were obtained at pressure ratios to 4.5, and pitot-pressure surveys of the nozzle exit plane were made. Two configurations were tested: the swivel nozzle with a square contour of the leading edge of the ventral duct inlet, and the same nozzle with a round leading edge contour. The swivel nozzle showed good performance overall, and the round-leading edge configuration showed an improvement in performance over the square-leading edge configuration

Performance characteristics of a variable-area vane nozzle for vectoring an ASTOVL exhaust jet up to 45 deg

Many conceptual designs for advanced short-takeoff, vertical landing (ASTOVL) aircraft need exhaust nozzles that can vector the jet to provide forces and moments for controlling the aircraft's movement or attitude in flight near the ground. A type of nozzle that can both vector the jet and vary the jet flow area is called a vane nozzle. Basically, the nozzle consists of parallel, spaced-apart flow passages formed by pairs of vanes (vanesets) that can be rotated on axes perpendicular to the flow. Two important features of this type of nozzle are the abilities to vector the jet rearward up to 45 degrees and to produce less harsh pressure and velocity footprints during vertical landing than does an equivalent single jet. A one-third-scale model of a generic vane nozzle was tested with unheated air at the NASA Lewis Research Center's Powered Lift Facility. The model had three parallel flow passages. Each passage was formed by a vaneset consisting of a long and a short vane. The longer vanes controlled the jet vector angle, and the shorter controlled the flow area. Nozzle performance for three nominal flow areas (basic and plus or minus 21 percent of basic area), each at nominal jet vector angles from -20 deg (forward of vertical) to +45 deg (rearward of vertical) are presented. The tests were made with the nozzle mounted on a model tailpipe with a blind flange on the end to simulate a closed cruise nozzle, at tailpipe-to-ambient pressure ratios from 1.8 to 4.0. Also included are jet wake data, single-vaneset vector performance for long/short and equal-length vane designs, and pumping capability. The pumping capability arises from the subambient pressure developed in the cavities between the vanesets, which could be used to aspirate flow from a source such as the engine compartment. Some of the performance characteristics are compared with characteristics of a single-jet nozzle previously reported