Spending Policies For Foundations: The Case For Increased Grants Payout

Payout by private foundations and public charities is the source of funds from which flow the grants that support much of the non-profit activity in the United States. This report offers a broader perspective on foundation growth - including investments, gifts, and new formations - painting a picture of philanthropic finances with a lesser emphasis on endowments. Among the topics dealt with in the text are grants payout, foundation growth, and perpetuity and payout. Full contents listing is provided

Analytical model for the uncorrelated emittance evolution of externally injected beams in plasma-based accelerators

This article introduces an analytical formalism for the calculation of the evolution of beam moments and the transverse emittance for beams which are externally injected into plasma wakefield accelerators. This formalism is then applied to two scenarios with increasing complexity - a single beam slice without energy gain and a single beam slice with energy gain, both propagating at a fixed co-moving position behind the driver. The obtained results are then compared to particle-in-cell (PIC) simulations as well as results obtained using an semi-analytic numerical approach (SANA). We find excellent agreement between results from the analytical model and from SANA and PIC

Beyond DSGE Models: Toward an Empirically Based Macroeconomics

This paper argues that macro models should be as simple as possible, but not more so. Existing models are “more so” by far. It is time for the science of macro to step beyond representative agent, DSGE models and focus more on alternative heterogeneous agent macro models that take agent interaction, complexity, coordination problems and endogenous learning seriously. It further argues that as analytic work on these scientific models continues, policy-relevant models should be more empirically based; policy researchers should not approach the data with theoretical blinders on; instead, they should follow an engineering approach to policy analysis and let the data guide their choice of the relevant theory to apply.

Wakefield-Induced Ionization injection in beam-driven plasma accelerators

We present a detailed analysis of the features and capabilities of Wakefield-Induced Ionization (WII) injection in the blowout regime of beam driven plasma accelerators. This mechanism exploits the electric wakefields to ionize electrons from a dopant gas and trap them in a well-defined region of the accelerating and focusing wake phase, leading to the formation of high-quality witness-bunches [Martinez de la Ossa et al., Phys. Rev. Lett. 111, 245003 (2013)]. The electron-beam drivers must feature high-peak currents ($I_b^0\gtrsim 8.5~\mathrm{kA}$) and a duration comparable to the plasma wavelength to excite plasma waves in the blowout regime and enable WII injection. In this regime, the disparity of the magnitude of the electric field in the driver region and the electric field in the rear of the ion cavity allows for the selective ionization and subsequent trapping from a narrow phase interval. The witness bunches generated in this manner feature a short duration and small values of the normalized transverse emittance ($k_p\sigma_z \sim k_p\epsilon_n \sim 0.1$). In addition, we show that the amount of injected charge can be adjusted by tuning the concentration of the dopant gas species, which allows for controlled beam loading and leads to a reduction of the total energy spread of the witness beams. Electron bunches, produced in this way, fulfil the requirements to drive blowout regime plasma wakes at a higher density and to trigger WII injection in a second stage. This suggests a promising new concept of self-similar staging of WII injection in steps with increasing plasma density, giving rise to the potential of producing electron beams with unprecedented energy and brilliance from plasma-wakefield accelerators

The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma

Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM). This regimen modestly prolongs overall survival, also if, in light of the still dismal prognosis, further improvements are desperately needed, especially in the patients with O6- methylguanine-DNA-methyltransferase (MGMT) unmethylated tumors, in which the benefit of standard treatment is less. Tinostamustine (EDO-S101) is a first-in-class alkylating deacetylase inhibitor (AK-DACi) molecule that fuses the DNA damaging effect of bendamustine with the fully functional pan-histone deacetylase (HDAC) inhibitor, vorinostat, in a completely new chemical entity. Methods: Tinostamustine has been tested in models of GBM by using 13 GBM cell lines and seven patient-derived GBM proliferating/stem cell lines in vitro. U87MG and U251MG (MGMT negative), as well as T98G (MGMT positive), were subcutaneously injected in nude mice, whereas luciferase positive U251MG cells and patient-derived GBM stem cell line (CSCs-5) were evaluated the orthotopic intra-brain in vivo experiments. Results: We demonstrated that tinostamustine possesses stronger antiproliferative and pro-apoptotic effects than those observed for vorinostat and bendamustine alone and similar to their combination and irrespective of MGMT expression. In addition, we observed a stronger radio-sensitization of single treatment and temozolomide used as control due to reduced expression and increased time of disappearance of γH2AX indicative of reduced signal and DNA repair. This was associated with higher caspase-3 activation and reduction of RT-mediated autophagy. In vivo, tinostamustine increased time-to-progression (TTP) and this was additive/synergistic to RT. Tinostamustine had significant therapeutic activity with suppression of tumor growth and prolongation of DFS (disease-free survival) and OS (overall survival) in orthotopic intra-brain models that was superior to bendamustine, RT and temozolomide and showing stronger radio sensitivity. Conclusions: Our data suggest that tinostamustine deserves further investigation in patients with glioblastoma

The Minsky-Kindleberger connection and the making of manias, panics, and crashes

https://journals.openedition.org/oeconomia/1648

Chirp mitigation of plasma-accelerated beams using a modulated plasma density

Plasma-based accelerators offer the possibility to drive future compact light sources and high-energy physics applications. Achieving good beam quality, especially a small beam energy spread, is still one of the major challenges. For stable transport, the beam is located in the focusing region of the wakefield which covers only the slope of the accelerating field. This, however, imprints a longitudinal energy correlation (chirp) along the bunch. Here, we propose an alternating focusing scheme in the plasma to mitigate the development of this chirp and thus maintain a small energy spread

New evidence on Allyn Young's style and influence as a teacher

This paper publishes the hitherto unpublished correspondence between Allyn Abbott Young's biographer Charles Blitch and 17 of Young's former students or associates. Together with related biographical and archival material, the paper shows the way in which this adds to our knowledge of Young's considerable influence as a teacher upon some of the twentieth century's greatest economists. The correspondents are as follows: James W Angell, Colin Clark, Arthur H Cole, Lauchlin Currie, Melvin G de Chazeau, Eleanor Lansing Dulles, Howard S Ellis, Frank W Fetter, Earl J Hamilton, Seymour S Harris, Richard S Howey, Nicholas Kaldor, Melvin M Knight, Bertil Ohlin, Geoffrey Shepherd, Overton H Taylor, and Gilbert Walker

Financialization and its discontents

Finance is not something separate from society. It is neither a Marxian superstructure nor a monetarist veil, but rather the very substance of modern social relations, a web of time-dated promises to pay that stretches from now into the future, and from here around the globe. Financial relationships are not about mediating something else on the ‘real’ side of the economy; they are the constitutive relationships of the whole system. Financial globalization and global financialization have produced a global Financial Society, hierarchical and inherently unstable. The problem confronting social analysts is not so much to find the social in the money grid – the money grid is already social – but rather to understand the dynamical operations of that grid on its own terms. This essay sketches the fundamental processes that produce and reproduce Financial Society – settlement and market-making – as an attempt to provide a realistic point of departure for any feasible project of reform