3-Anilinothio­carbonyl-4-hydroxy­chromen-2-one

The geometrical parameters of the title compound, C16H11NO3S, are in the usual ranges. The two aromatic residues are not coplanar and are twisted by a dihedral angle of 66.63 (6)°. The crystal structure is stabilized by N—H⋯O and O—H⋯S inter­actions

Evaluation of dose dependent analgesic response by extracts of Myristica fragrans on albino wistar rats: an experimental study

Background: The objective of the study was to evaluate analgesic activity of ethanolic extract, methanol and benzene fraction of Myristica fragrans on wistar albino rats.Methods: The present study was carried out in the department of pharmacology JNMC AMU and F.H. Medical College, Agra. The analgesic activity was evaluated by employing the Eddy’s hot plate method and tail flick response method. In both the tests, Rats of either sex weighing 150-200 g were used. The total number of animals n=36 were allocated to six groups. Each group consist of six animals each. The response noted in animals that were tested by hot plate method was reaction time for licking/biting of both the paws before and after administration of control & test drugs. However in Tail flick test, the pain threshold response was recorded before and after administration of control & test drugs. The statistical analysis was done by using one-way ANOVA. The data is expressed as Mean±SEM. P<0.05 was considered to be statistically significant.Results: Ethanolic extracts and methanol fraction of M. fragrans showed statistically significant (p<0.001) increase in reaction time for licking/biting in hot plate method. On the contrary a significant increase in pain threshold was also recorded in tail flick response test. It is interesting to note that no significant degree of analgesia related to any dose of benzene fraction was observed.Conclusions: The present study reveals the dose dependent significant analgesic activity of the extracts of M. fragrans i.e. ethanolic extracts and methanol fraction in both the test. However, the degree of analgesia was recorded significantly higher in groups received higher doses of extracts of M. fragrans

Fatty acid composition, antioxidant, antifungal activities and functional group analysis of Corylus jacquemontii seeds grown in Kashmir

Corylus jacquemontii (Decne.) is an important aromatic plant possessing nutritional and various therapeutic properties. This plant has got wide abundance in the Kashmir region with very low care cost. In this study, Soxhlet extraction was used to obtain different seed extracts. The highest yield observed was 32.25% and 30.27% in petroleum ether and acetone extracts, respectively. Gas chromatography coupled with a flame ionization detector was used to determine the fatty acid profile of petroleum ether extract. Unsaturated fatty acids were found in the dominant amount, notably 79.33% oleic acid. The antifungal activity against Aspergillus niger, A. fumigates, and Penicillium marneffei and antioxidant assays such as CAT, APx, SOD, DPPH were observed in petroleum ether, ethyl acetate, acetone, and methanol extracts. The dominant inhibition against A. niger and A. fumigates was displayed by methanol extract with 16.78 mm and 19.23 mm inhibition zone, respectively, while P. marneffei methanol (20.98 mm) acetone (20.27 mm) extracts were most effective. Moreover, all extracts displayed good antioxidant activities. These results increased the attention towards the importance of the present study

7,7′,8,8′-Tetra­meth­oxy-4,4′-dimethyl-3,3′-bicoumarin

In the crystal structure, the title compound, C24H22O8, lies on a twofold rotation axis and the asymmetric unit comprises one half-mol­ecule. The dihedral angle formed by the coumarin unit with the symmetry-related part is 74.78 (14)°. One of the meth­oxy groups attached to the coumarin unit is considerably twisted, making an angle of 87.17 (17)° with respect to the coumarin unit; the other is twisted by 0.66 (19)°. No classical hydrogen bonds are found in the sturcture; only a weak C—H⋯π inter­action and short intra­molecular O⋯O contacts [2.683 (2)–2.701 (2) Å] are observed

SYNTHESIS, CHARACTERIZATIONAND ANTIMICROBIALACTIVITYOF FRIEDELIN [2, 3-d] SElENADIAZOlE

ABSTRACT The new 1, 2, 3, selenadiazole derivative (3) was prepared from friedelin (1) via the co"esponding semicarbazone (2) using Lalezari cyclization. The compounds were prepared, separated and characterized on the basis of microanalysis and spectral studies. The isolated friedelin and its selenadiazole were screened in vitro for their antimicrobial activities against various pathogenic bacterial were found to be highly active against al/ the selected pathogens. Compound 3 showed an inhibition zone of 14 mm and 12 mm respectively against highly resistant S. albus and C. albicans. A general mechanistic scheme for these reactions is also suggested based on current and previous results

2-Acetonyl-2-hydroxy­indan-1,3-dione

In the title compound, C12H10O4, the five-membered ring adopts an envelope conformation, with the Csp 3 atom at the flap [deviation = 0.145 (2) Å]. In the crystal structure, mol­ecules are linked by inter­molecular O—H⋯O and C—H⋯O hydrogen bonds, forming a three-dimensional network

6,8-Diiodo-5,7-dimeth­oxy-4-methyl­coumarin

In the title compound, C12H10I2O4, the meth­oxy groups are twisted considerably with respect to the plane of the aromatic ring [CH3—O—C—C torsion angles = −85.9 (3) and −92.8 (3)°]. In the crystal, mol­ecules are linked by weak C—H⋯O hydrogen bonds and O⋯I contacts [3.194 (2) Å]

8-Iodo-5,7-dimeth­oxy-4-methyl-2H-chromen-2-one

In the title compound, C12H11IO4, the C and O atoms of both meth­oxy groups lie very close to the mean plane of the six C atoms of the benzene ring. The O and C atoms of the group lying closest to the I atom are 0.012 (3) and 0.022 (4) Å, respectively, out of the mean plane. For the other meth­oxy group, the corresponding distances are 0.020 (3) and 0.078 (4) Å. In the crystal, there are only very weak inter­molecular C—H⋯O hydrogen bonds and O⋯I contacts [3.080 (2) Å]. The mol­ecules are approximately parallel to (100), forming a layered structure

7,7′,8,8′-Tetra­meth­oxy-4,4′-dimethyl-3,5′-bichromene-2,2′-dione

In the title mol­ecule, C24H22O8, the mean planes of the two coumarin units are inclined to each other at a dihedral angle of 79.93 (3)°. The attached meth­oxy groups form torsion angles of 7.65 (19) and 78.36 (14)° with respect to one coumarin unit, and angles of 9.01 (16) and 99.08 (11)° with respect to the other coumarin unit. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds connect pairs of mol­ecules to form dimers, generating R 2 2(16) and R 2 2(18) rings; the dimers are linked by further weak inter­molecular C—H⋯O hydrogen bonds, forming extended chains. Additional stabil­ization is provided by weak C—H⋯π inter­actions