A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines

The Framingham Heart Study is a well known longitudinal cohort study. In recent years, the community-based Framingham Heart Study has embarked on genome-wide association studies. In this paper, we present a Framingham Heart Study genome-wide analysis for fasting triglycerides trait in the Genetic Analysis Workshop16 Problem 2 using multivariate adaptive splines for the analysis of longitudinal data (MASAL). With MASAL, we are able to perform analysis of genome-wide data with longitudinal phenotypes and covariates, making it possible to identify genes, gene-gene, and gene-environment (including time) interactions associated with the trait of interest. We conducted a permutation test to assess the associations between MASAL selected markers and triglycerides trait and report significant gene-gene and gene-environment interaction effects on the trait of interest

Memory management in genome-wide association studies

Genome-wide association is a powerful tool for the identification of genes that underlie common diseases. Genome-wide association studies generate billions of genotypes and pose significant computational challenges for most users including limited computer memory. We applied a recently developed memory management tool to two analyses of North American Rheumatoid Arthritis Consortium studies and measured the performance in terms of central processing unit and memory usage. We conclude that our memory management approach is simple, efficient, and effective for genome-wide association studies

Optimization of Electronic Nose Sensor Array for Tea Aroma Detecting Based on Correlation Coefficient and Cluster Analysis

The electronic nose system is widely used in tea aroma detecting, and the sensor array plays a fundamental role for obtaining good results. Here, a sensor array optimization (SAO) method based on correlation coefficient and cluster analysis (CA) is proposed. First, correlation coefficient and distinguishing performance value (DPV) are calculated to eliminate redundant sensors. Then, the sensor independence is obtained through cluster analysis and the number of sensors is confirmed. Finally, the optimized sensor array is constructed. According to the results of the proposed method, sensor array for green tea (LG), fried green tea (LF) and baked green tea (LB) are constructed, and validation experiments are carried out. The classification accuracy using methods of linear discriminant analysis (LDA) based on the average value (LDA-ave) combined with nearest-neighbor classifier (NNC) can almost reach 94.44~100%. When the proposed method is used to discriminate between various grades of West Lake Longjing tea, LF can show comparable performance to that of the German PEN2 electronic nose. The electronic nose SAO method proposed in this paper can effectively eliminate redundant sensors and improve the quality of original tea aroma data. With fewer sensors, the optimized sensor array contributes to the miniaturization and cost reduction of the electronic nose system

Optimization of Electronic Nose Sensor Array for Tea Aroma Detecting Based on Correlation Coefficient and Cluster Analysis

The electronic nose system is widely used in tea aroma detecting, and the sensor array plays a fundamental role for obtaining good results. Here, a sensor array optimization (SAO) method based on correlation coefficient and cluster analysis (CA) is proposed. First, correlation coefficient and distinguishing performance value (DPV) are calculated to eliminate redundant sensors. Then, the sensor independence is obtained through cluster analysis and the number of sensors is confirmed. Finally, the optimized sensor array is constructed. According to the results of the proposed method, sensor array for green tea (LG), fried green tea (LF) and baked green tea (LB) are constructed, and validation experiments are carried out. The classification accuracy using methods of linear discriminant analysis (LDA) based on the average value (LDA-ave) combined with nearest-neighbor classifier (NNC) can almost reach 94.44~100%. When the proposed method is used to discriminate between various grades of West Lake Longjing tea, LF can show comparable performance to that of the German PEN2 electronic nose. The electronic nose SAO method proposed in this paper can effectively eliminate redundant sensors and improve the quality of original tea aroma data. With fewer sensors, the optimized sensor array contributes to the miniaturization and cost reduction of the electronic nose system.</jats:p