A SIMPLIFIED METHOD OF DETERMINING THE ELASTIC STATE OF THERMAL STRESS IN A THIN, FLAT PLATE OF FINITE DIMENSIONS

Elastic state determination of thermal stress in thin, flat plate of finite dimension

The clinical pharmacology of intranasal l-methamphetamine.

BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 hours) then at 2 and 4 (32 and 64 inhalations) times this dose. In a separate session intravenous phenylephrine (200 microg) and l-methamphetamine (5 mg) were given to define alpha agonist pharmacology and bioavailability. Physiological, cardiovascular, pharmacokinetic, and subjective effects were measured.ResultsPlasma l-methamphetamine levels were often below the level of quantification so bioavailability was estimated by comparing urinary excretion of the intravenous and inhaled doses, yielding delivered dose estimates of 74.0 +/- 56.1, 124.7 +/- 106.6, and 268.1 +/- 220.5 microg for ascending exposures (mean 4.2 +/- 3.3 microg/inhalation). Physiological changes were minimal and not dose-dependent. Small decreases in stroke volume and cardiac output suggesting mild cardiodepression were seen.ConclusionInhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant

Triomensional plasticity using BIEM

This paper presents the application of BIE techniques to elastoplastic three-dimensional problems. Along with the general procedures the needed integrations are described in detail and so is the flow chart of the written program

Application of Design of Experiments (DOE) on the Processing of Rapid Prototyped Samples

The purpose of this experiment was to improve the Fused Deposition Modeling Process by examining the tensile strength of samples fabricated in a Stratasys FDM 1650 Machine utilizing the methods of Design of Experiments. A two-level, four-factor, full factorial experiment was conducted. The selected factors were temperature, air gap, slice thickness, and raster orientation. A regression equation determined the level each factor should be set in order to optimize the FDM machine settings. It was found that single factors - small air gap, small layer thickness and low raster orientation, as well as the interaction between high temperature and small layer thickness yielded the greatest effect the response.Mechanical Engineerin

Daphnia predation on the amphibian chytrid fungus and its impacts on disease risk in tadpoles

Direct predation upon parasites has the potential to reduce infection in host populations. For example, the fungal parasite of amphibians, B atrachochytrium dendrobatidis ( B d), is commonly transmitted through a free‐swimming zoospore stage that may be vulnerable to predation. Potential predators of B d include freshwater zooplankton that graze on organisms in the water column. We tested the ability of two species of freshwater crustacean ( D aphnia magna and D . dentifera ) to consume B d and to reduce B d density in water and infection in tadpoles. In a series of laboratory experiments, we allowed D aphnia to graze in water containing B d while manipulating D aphnia densities, D aphnia species identity, grazing periods and concentrations of suspended algae ( A nkistrodesmus falcatus ). We then exposed tadpoles to the grazed water. We found that high densities of D . magna reduced the amount of Bd detected in water, leading to a reduction in the proportion of tadpoles that became infected. Daphnia dentifera , a smaller species of D aphnia , also reduced B d in water samples, but did not have an effect on tadpole infection. We also found that algae affected B d in complex ways. When D aphnia were absent, less B d was detected in water and tadpole samples when concentrations of algae were higher, indicating a direct negative effect of algae on B d. When D aphnia were present, however, the amount of B d detected in water samples showed the opposite trend, with less B d when densities of algae were lower. Our results indicate that D aphnia can reduce B d levels in water and infection in tadpoles, but these effects vary with species, algal concentration, and D aphnia density. Therefore, the ability of predators to consume parasites and reduce infection is likely to vary depending on ecological context. We tested the ability of two species of freshwater crustacean ( Daphnia magna and D. dentifera ) to consume zoospores of the amphibian parasite, Batrachochytrium dendrobatidis (Bd), and to reduce parasite density in water and infection in tadpoles. In a series of laboratory experiments, we allowed Daphnia to graze in water containing Bd, then exposed tadpoles to the grazed water. Our results show that Daphnia can reduce Bd levels in water and infection in tadpoles, but these effects vary with species, algal concentration and Daphnia density.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100311/1/ece3777.pd

Signs of low frequency dispersions in disordered binary dielectric mixtures (50-50)

Dielectric relaxation in disordered dielectric mixtures are presented by emphasizing the interfacial polarization. The obtained results coincide with and cause confusion with those of the low frequency dispersion behavior. The considered systems are composed of two phases on two-dimensional square and triangular topological networks. We use the finite element method to calculate the effective dielectric permittivities of randomly generated structures. The dielectric relaxation phenomena together with the dielectric permittivity values at constant frequencies are investigated, and significant differences of the square and triangular topologies are observed. The frequency dependent properties of some of the generated structures are examined. We conclude that the topological disorder may lead to the normal or anomalous low frequency dispersion if the electrical properties of the phases are chosen properly, such that for ``slightly'' {\em reciprocal mixture}--when $\sigma_1\gg\sigma_2$, and $\epsilon_1<\epsilon_2$--normal, and while for ``extreme'' {\em reciprocal mixture}--when $\sigma_1\gg\sigma_2$, and $\epsilon_1\ll\epsilon_2$--anomalous low frequency dispersions are obtained. Finally, comparison with experimental data indicates that one can obtain valuable information from simulations when the material properties of the constituents are not available and of importance.Comment: 13 pages, 7 figure

The Viscous Nonlinear Dynamics of Twist and Writhe

Exploiting the "natural" frame of space curves, we formulate an intrinsic dynamics of twisted elastic filaments in viscous fluids. A pair of coupled nonlinear equations describing the temporal evolution of the filament's complex curvature and twist density embodies the dynamic interplay of twist and writhe. These are used to illustrate a novel nonlinear phenomenon: ``geometric untwisting" of open filaments, whereby twisting strains relax through a transient writhing instability without performing axial rotation. This may explain certain experimentally observed motions of fibers of the bacterium B. subtilis [N.H. Mendelson, et al., J. Bacteriol. 177, 7060 (1995)].Comment: 9 pages, 4 figure

Lubricating Bacteria Model for Branching growth of Bacterial Colonies

Various bacterial strains (e.g. strains belonging to the genera Bacillus, Paenibacillus, Serratia and Salmonella) exhibit colonial branching patterns during growth on poor semi-solid substrates. These patterns reflect the bacterial cooperative self-organization. Central part of the cooperation is the collective formation of lubricant on top of the agar which enables the bacteria to swim. Hence it provides the colony means to advance towards the food. One method of modeling the colonial development is via coupled reaction-diffusion equations which describe the time evolution of the bacterial density and the concentrations of the relevant chemical fields. This idea has been pursued by a number of groups. Here we present an additional model which specifically includes an evolution equation for the lubricant excreted by the bacteria. We show that when the diffusion of the fluid is governed by nonlinear diffusion coefficient branching patterns evolves. We study the effect of the rates of emission and decomposition of the lubricant fluid on the observed patterns. The results are compared with experimental observations. We also include fields of chemotactic agents and food chemotaxis and conclude that these features are needed in order to explain the observations.Comment: 1 latex file, 16 jpeg files, submitted to Phys. Rev.

Lesbian and bisexual women's experiences of sexuality-based discrimination and their appearance concerns

Lesbian and bisexual women frequently experience sexuality-based discrimination, which is often based on others' judgements about their appearance. This short article aims to explore whether there is a relationship between lesbian and bisexual women's experiences of sexuality-based discrimination and their satisfaction with the way that they look. Findings from an online survey suggest that discrimination is negatively related to appearance satisfaction for lesbian women, but not for bisexual women. It is argued that this difference exists because lesbian appearance norms are more recognisable and distinctive than bisexual women's appearance norms

Twirling and Whirling: Viscous Dynamics of Rotating Elastica

Motivated by diverse phenomena in cellular biophysics, including bacterial flagellar motion and DNA transcription and replication, we study the overdamped nonlinear dynamics of a rotationally forced filament with twist and bend elasticity. Competition between twist injection, twist diffusion, and writhing instabilities is described by a novel pair of coupled PDEs for twist and bend evolution. Analytical and numerical methods elucidate the twist/bend coupling and reveal two dynamical regimes separated by a Hopf bifurcation: (i) diffusion-dominated axial rotation, or twirling, and (ii) steady-state crankshafting motion, or whirling. The consequences of these phenomena for self-propulsion are investigated, and experimental tests proposed.Comment: To be published in Physical Review Letter