Potassium {4-[(3S,6S,9S)-3,6-dibenzyl-9-isopropyl-4,7,10-trioxo-11–oxa-2,5,8-triazadodecyl]phenyl}trifluoroborate

[[abstract]]The reported compound 4 was synthesized and fully characterized by 1H NMR, 13C NMR, 11B NMR, 19F NMR, and high resolution mass spectrometry.[[booktype]]電子版[[countrycodes]]CH

物理模型試驗應用於順向坡板岩變形特性之研究

本文主要探討臺灣板岩順向坡變形特性，藉由現場調查、地形分析與物理模型試驗說明板岩不同條件下之重力變形特性，並推估板岩變形過程與潛在崩壞機制。結果顯示，坡趾侵蝕透空與降雨入滲機制為板岩變形之關鍵，其將造成板岩材料強度弱化加速發生變形。此外，板岩變形初始發生於崖頂張力區，坡體將沿著高角度葉理滑移，並於侵蝕弱化帶附近形成剪切破壞或複合型破壞。而變形範圍內具有相當多葉理張開之現象，其將有助於地表水與地下水滲入，促使板岩變形區加速變形至崩壞。This paper focuses on characterizing the deformation of consequent slate slopes in Taiwan. Onsite surveys, terrain analysis, and a physical model test are used to describe the characteristics of gravity-driven deformation under various conditions and identify the process of slate deformation as well as potential failure mechanisms. Slate deformation is shown to begin in the tension zone at cliff tops, wherein the slope body slips along the highly inclined foliation, contributing to shear failure or composite failure near the eroded zone of weakness. The phenomenon of foliation opening is widespread within the area of deformation, enabling surface water and groundwater to seep in, thereby accelerating deformation and failure in the slate deformation zone

implications for health and disease

Many aspects of human physiology and behavior display rhythmicity with a period of approximately 24 h. Rhythmic changes are controlled by an endogenous time keeper, the circadian clock, and include sleep-wake cycles, physical and mental performance capability, blood pressure, and body temperature. Consequently, many diseases, such as metabolic, sleep, autoimmune and mental disorders and cancer, are connected to the circadian rhythm. The development of therapies that take circadian biology into account is thus a promising strategy to improve treatments of diverse disorders, ranging from allergic syndromes to cancer. Circadian alteration of body functions and behavior are, at the molecular level, controlled and mediated by widespread changes in gene expression that happen in anticipation of predictably changing requirements during the day. At the core of the molecular clockwork is a well-studied transcription-translation negative feedback loop. However, evidence is emerging that additional post-transcriptional, RNA-based mechanisms are required to maintain proper clock function. Here, we will discuss recent work implicating regulated mRNA stability, translation and alternative splicing in the control of the mammalian circadian clock, and its role in health and disease

Measuring Higher-Order Rationality with Belief Control

Determining an individual's strategic reasoning capability based solely on choice data is a complex task. This complexity arises because sophisticated players might have non-equilibrium beliefs about others, leading to non-equilibrium actions. In our study, we pair human participants with computer players known to be fully rational. This use of robot players allows us to disentangle limited reasoning capacity from belief formation and social biases. Our results show that, when paired with robots, subjects consistently demonstrate higher levels of rationality and maintain stable rationality levels across different games compared to when paired with humans. This suggests that strategic reasoning might indeed be a consistent trait in individuals. Furthermore, the identified rationality limits could serve as a measure for evaluating an individual's strategic capacity when their beliefs about others are adequately controlled.Comment: The experimental design and the analysis plan are pre-registered on Open Science Framework (https://osf.io/gye4u/). The experimental instructions can be found at https://mjfong.github.io/SI_MHOR_final.pd

A Query-based Routing Table Update Mechanism for Content-Centric Network

Due to the popularity of network applications, such as multimedia, online shopping, Internet of Things (IoT), and 5G, the contents cached in the routers are frequently replaced in Content-Centric Networking (CCN). Generally, cache miss causes numerous propagated packets to get the required content that deteriorates network congestion and delay the response time of consumers. Many caching strategies and routing policies were proposed to solve the problem. This paper presents an alternative solution by designing a query-based routing table update mechanism to increase the accuracy of routing tables. By adding an additional query content in interest packets, our approach real-time explores the cached content in routers and updated the routing table accordingly. This paper uses a general network simulator, ndnSIM, to compare basic CCN and our approach. The results show that our approach improves the response time of consumers and network congestion and is compatible with general forwarding strategies.Comment: 6 pages, 14 figures, conference. ISBN:978-1-7281-9256-

Herb-Drug Pharmacokinetic Interaction of a Traditional Chinese Medicine Jia-Wei-Xiao-Yao-San with 5-Fluorouracil in the Blood and Brain of Rat Using Microdialysis

According to a survey from the National Health Insurance Research Database (NHIRD), Jia-Wei-Xiao-Yao-San (JWXYS) is the most popular Chinese medicine for cancer patients in Taiwan. 5-Fluorouracil (5-FU) is a general anticancer drug for the chemotherapy. To investigate the herb-drug interaction of JWXYS on pharmacokinetics of 5-FU, a microdialysis technique coupled with a high-performance liquid chromatography system was used to monitor 5-FU in rat blood and brain. Rats were divided into four parallel groups, one of which was treated with 5-FU (100 mg/kg, i.v.) alone and the remaining three groups were pretreated with a different dose of JWXYS (600, 1200, or 2400 mg/kg/day for 5 consecutive days) followed by a combination with 5-FU. This study demonstrates that 5-FU with JWXYS (600 mg/kg/day or 1200 mg/kg/day) has no significant effect on the pharmacokinetics of 5-FU in the blood and brain. However, JWXYS (2400 mg/kg/day) coadministered with 5-FU extends the elimination half-life and increases the volume of distribution of 5-FU in the blood. The elimination half-life of 5-FU in the brain for the pretreatment group with 2400 mg/kg/day of JWXYS is significantly longer than that for the group treated with 5-FU alone and also reduces the clearance. This study provides practical dosage information for clinical practice and proves the safety of 5-FU coadministered with JWXYS

Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis

Aeginetia indica Linn. (Guan-Jen-Huang, GJH), a traditional Chinese herb, has the potential to be an immunomodulatory agent. The purpose of this study was to explore the effect of GJH in the treatment of renal cancer. Concentration-effect curves for the influence of GJH on cellular proliferation showed a biphasic shape. Besides, GJH had a synergistic effect on cytotoxicity when combined with 5-fluorouracil (5-FU)which may be due to the alternation of the chemotherapeutic agent resistance-related genes and due to the synergistic effects on apoptosis. In addition, treatment with GJH extract markedly reduced 786-O cell adherence to human umbilical vein endothelial cells (HUVECs) and decreased 786-O cell migration and invasion. In a xenograft animal model, GJH extract had an inhibitory effect on tumor cell-induced metastasis. Moreover, western blot analysis showed that the expression of intercellular adhesion molecule-1 (ICAM-1) in 786-O cells was significantly decreased by treatment with GJH extract through inactivation of nuclear factor-κB (NF–κB). These results suggest that GJH extract has a synergistic effect on apoptosis induced by chemotherapeutic agents and an inhibitory effect on cell adhesion, migration, and invasion, providing evidence for the use of water-based extracts of GJH as novel alternative therapeutic agents in the treatment of human renal cancer