Non-Measles Hemadsorption in a Cell Line Persistently Infected with Measles Virus (BGM/MV)

Adsorption of Rhesus monkey erythrocytes to the plasma membranes of measles virus infected cells is frequently carried out to detect the presence of plasma membrane-associated measles virus hemagglutinin. The hemagglutinin is a viral genome-coded structural glycoprotein of the measles virion that is associated with the plasma membrane of the host cell during measles virus replication. BGM/MV, anon-virogenic line of African green monkey kidney cells persistently-infected with measles virus, adsorbed Rhesus monkey erythrocytes in an inverse fashion relative to the number of cells present in the culture and the time post-seeding. Serological studies employing the hemadsorption-inhibition and membrane immunofluorescence assay procedures, suggested that this phenomenon was not mediated by the viral hemagglutinin. Assays for Simian virus-5 and mycoplasma, contaminating agents that induce erythrocyte adsorption, were negative. Incubation of BGM/MV cells at 33°C or with graded concentrations of fetal calf serum, to stimulate the metabolism of resting (Go) cells, suggested that adsorption was related to a phase(s) of the cell growth cycle other than Go₁, for adsorption was prolonged and stimulated in a dose-response fashion, respectively. Comparative adsorption studies employing the parent cell line (BGM), not infected with measles virus, were performed using various species of erythrocytes. While both cell lines adsorbed Rhesus monkey erythrocytes in an inverse fashion relative to cell density, differences were noted in the adsorption of some of the other species of erythrocytes. These data suggest that Rhesus monkey erythrocyte adsorption to BGM/MV cells was mediated by a receptor(s) of cellular origin

The esophagogastric junctional adenocarcinoma an increasing disease

Identifying and defining the esophagogastric junctional adenocarcinoma (EGJA) as an independent disease apart from gastric cancer (GC) and esophagus cancer (EG) it has always been a difficult issue entailing doubts about the appropriate therapeutic approach

Systematic Review and Meta-Analysis of the Occurrence of ESKAPE Bacteria Group in Dogs, and the Related Zoonotic Risk in Animal-Assisted Therapy, and in Animal-Assisted Activity in the Health Context

Animal-assisted interventions are widely implemented in different contexts worldwide. Particularly, animal-assisted therapies and animal-assisted activities are often implemented in hospitals, rehabilitation centers, and other health facilities. These interventions bring several benefits to patients but can also expose them to the risk of infection with potentially zoonotic agents. The dog is the main animal species involved used in these interventions. Therefore, we aimed at collecting data regarding the occurrence of the pathogens ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) in dogs, in order to draft guidelines concerning the possible monitoring of dogs involved in animal-assisted therapies and animal-assisted activities in healthcare facilities. We performed a literature search using the PRISMA guidelines to examine three databases: PubMed, Web of Science, and Scopus. Out of 2604 records found, 52 papers were identified as eligible for inclusion in the review/meta-analysis. Sixteen papers reported data on E. faecium; 16 on S. aureus; nine on K. pneumoniae; four on A. baumannii; eight on P. aeruginosa; and six on Enterobacter spp. This work will contribute to increased awareness to the potential zoonotic risks posed by the involvement of dogs in animal-assisted therapies, and animal-assisted activities in healthcare facilities

Efficient Approach for OS-CFAR 2D Technique Using Distributive Histograms and Breakdown Point Optimal Concept applied to Acoustic Images

In this work, a new approach to improve the algorithmic efficiency of the Order Statistic-Constant False Alarm Rate (OS-CFAR) applied in two dimensions (2D) is presented. OS-CFAR is widely used in radar technology for detecting moving objects as well as in sonar technology for the relevant areas of segmentation and multi-target detection on the seafloor. OS-CFAR rank orders the samples obtained from a sliding window around a test cell to select a representative sample that is used to calculate an adaptive detection threshold maintaining a false alarm probability. Then, the test cell is evaluated to determine the presence or absence of a target based on the calculated threshold. The rank orders allows that OS-CFAR technique to be more robust in multi-target situations and less sensitive than other methods to the presence of the speckle noise, but requires higher computational effort. This is the bottleneck of the technique. Consequently, the contribution of this work is to improve the OS-CFAR 2D with the distributive histograms and the optimal breakdown point optimal concept, mainly from the standpoint of efficient computation. In this way, the OS-CFAR 2D on-line computation was improved, by means of speeding up the samples sorting problem through the improvement in the calculus of the statistics order. The theoretical algorithm analysis is presented to demonstrate the improvement of this approach. Also, this novel efficient OS-CFAR 2D was contrasted experimentally on acoustic images.Fil: Villar, Sebastian Aldo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ingeniería Olavarría. Departamento de Electromecánica. Grupo INTELYMEC; ArgentinaFil: Menna, Bruno Victorio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ingeniería Olavarría. Departamento de Electromecánica. Grupo INTELYMEC; ArgentinaFil: Torcida, Sebastián. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Departamento de Matemática; ArgentinaFil: Acosta, Gerardo Gabriel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ingeniería Olavarría. Departamento de Electromecánica. Grupo INTELYMEC; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentin

Cambios en los fundamentos de la epistemología normativa y sus consecuencias para la metodología científica

Uno de los principales problemas para la epistemología radica en cómo fundamentar sus normas. La mayoría de los programas epistemológicos de la primera mitad de este siglo optaron por alguna forma de fundamentación a priori. En las últimas décadas, paralelamente a las críticas a los fundamentos logicistas, se han desarrollado programas normativos basados en otras fuentes epistémicas. En este trabajo intentaré explicitar las consecuencias que conllevan estos cambios para la metodología científica

La abducción y la inferencia a la mejor explicación

En este trabajo defenderé que, además del nombre, la AD y la IME presentan diferencias fundamentales -en particular, la clase de evidencia que consideran la clase de criterios que incorporan, y el grado de generalidad de las hipótesis que cada una de ellas evalúa-, y que son utilizadas por los científicos en distintos, contextos evaluatívos. Defenderé, también, •que la AD -a diferencia de la IME- no pertenece al contexto de justificación sino al contexto de plausibilidad -contexto en el que permite evaluar 'hipótesis de trabajo' o 'ideas seminales'- y que no es, tal como pretenden algunos críticos, una regla inferencia del contexto de descubrimiento

Measuring the spin up of the Accreting Millisecond Pulsar XTE J1751-305

We perform a timing analysis on RXTE data of the accreting millisecond pulsar XTE J1751-305 observed during the April 2002 outburst. After having corrected for Doppler effects on the pulse phases due to the orbital motion of the source, we performed a timing analysis on the phase delays, which gives, for the first time for this source, an estimate of the average spin frequency derivative = (3.7 +/- 1.0)E-13 Hz/s. We discuss the torque resulting from the spin-up of the neutron star deriving a dynamical estimate of the mass accretion rate and comparing it with the one obtained from X-ray flux. Constraints on the distance to the source are discussed, leading to a lower limit of \sim 6.7 kpc.Comment: 7 pages, 3 figures, Accepted for publication by MNRA

Age, Gender, and Socioeconomic Status Differences in Explicit and Implicit Beliefs About Effortlessly Perfect Self-Presentation

Feeling pressure to project an image of effortless perfection -- always appearing to perform with self-confidence and ease --- has been portrayed in the media as an increasingly common mental health vulnerability with potentially serious implications for college women. Despite this, almost no empirical research exists on effortlessly perfect self–presentation (EPSP) or demographic differences in it. • Some recent research suggests that perfectionism is on the rise among young people (Curran & Hill, 2017), and that it is more associated with mental health problems among students with high rather than low socioeconomic status (Lyman & Luthar, 2014). However, these studies did not focus specifically on EPSP, which differs from more typical perfectionism in that it prohibits apparent effort or anxiety while striving for perfection. Of the two published studies on EPSP, one did not examine demographic differences (Flett et al., 2016) and the other found higher endorsement of EPSP among men than among women (Travers et al., 2016). • Anonymous interviews we conducted about EPSP in 40 college students (Glazer et al., in prep) yielded very complex, self-contradictory responses suggesting that beliefs about EPSP may be characterized by stigma and ambivalence. For this reason we decided to focus the current study on indirect and implicit measures of EPSP. • In this study, participants completed three new scales about EPSP, along with the two existing measures of this phenomenon, several mental health measures, and demographics questions. They also rated the perceived social status and self-esteem of two target individuals in a within-person experimental design