Magnetic Raman Scattering in Two-Dimensional Spin-1/2 Heisenberg Antiferromagnets: Spectral Shape Anomaly and Magnetostrictive Effects

We calculate the Raman spectrum of the two-dimensional (2D) spin-1/2 Heisenberg antiferromagnet by exact diagonalization and quantum Monte Carlo techniques on clusters of up to 144 sites and, on a 16-site cluster, by considering the phonon-magnon interaction which leads to random fluctuations of the exchange integral. Results are in good agreement with experiments on various high-T_c precursors, such as La_2CuO_4 and YBa_2Cu_3O_{6.2}. In particular, our calculations reproduce the broad lineshape of the two-magnon peak, the asymmetry about its maximum, the existence of spectral weight at high energies, and the observation of nominally forbidden A_{1g} scattering.Comment: 12 pages, REVTEX, 1 postscript figur

El Reconocimiento De Los Ingresos y Los Estados Financieros De La Empresa Constructora P.A. Perú S.A.C.En El 2016

La Constructora P.A. Perú S.A.C. es una empresa dedicada al rubro de proyectos de ingeniería, brindan servicios de perforación horizontal y servicios de instalación interna de gas natural, siendo este último el de mayor importancia. La necesidad de la investigación se origina en la falta de conocimientos de los trabajadores involucrados del Proyecto de instalaciones internas y el área de almacén, ya que no existe una correcta comunicación con el departamento contabilidad. Observando esta problemática buscamos que se cumpla hacer una correcta aplicación de la información en las áreas pertinentes, los cuales son: 1- Capacitar al personal contable para un mejor conocimiento en los costos y gastos de los inventarios. 2- Diseñar el registro adecuado de las ventas para la determinación correcta de la obligación tributaria por venta de IGV. 3- Reportar correctamente la determinación de los estados de financieros a la gerencia para mejor toma de decisiones. La finalidad de este trabajo de investigación es aplicar herramientas útiles para la empresa y a su vez para empresas que crean pertinente utilizarlos, que permitan facilitar el proceso de verificación de materiales, un correcto reconocimiento de obligación tributaria y la correcta elaboración de los Estados financieros ayudando a saber el estado actual en la que se encuentra, de tal forma que ayude a mejorar los procesos contables en la empresa.The Constructora P.A. Peru S.A.C. It is a company dedicated to the field of engineering projects, which provides horizontal drilling services and internal installation services of natural gas, the latter being the most important. The need for this investigation originates in the lack of knowledge of the workers involved in the Project of internal facilities and the warehouse area since there is no adequate communication with the accounting department. When observing this problem, we look for a correct application of the information in the relevant areas, which are: 1- Train accounting personnel to better understand the costs and expenses of inventories. 2- Design the appropriate sales record for the correct determination of the tax obligation for the sale of VAT. 3- Properly report the determination of financial statements to management for better decision making. The purpose of this research is to apply useful tools for the company and, in turn, for companies that believe it is appropriate to use them to facilitate the process of material verification, correct recognition of tax liability and proper preparation of resources financial statements Help to know the current state in which it is located, in such a way that it helps to improve the accounting processes in the company.Trabajo de investigació

El Reconocimiento De Los Ingresos y Los Estados Financieros De La Empresa Constructora P.A. Perú S.A.C.En El 2016

La Constructora P.A. Perú S.A.C. es una empresa dedicada al rubro de proyectos de ingeniería, brindan servicios de perforación horizontal y servicios de instalación interna de gas natural, siendo este último el de mayor importancia. La necesidad de la investigación se origina en la falta de conocimientos de los trabajadores involucrados del Proyecto de instalaciones internas y el área de almacén, ya que no existe una correcta comunicación con el departamento contabilidad. Observando esta problemática buscamos que se cumpla hacer una correcta aplicación de la información en las áreas pertinentes, los cuales son: 1- Capacitar al personal contable para un mejor conocimiento en los costos y gastos de los inventarios. 2- Diseñar el registro adecuado de las ventas para la determinación correcta de la obligación tributaria por venta de IGV. 3- Reportar correctamente la determinación de los estados de financieros a la gerencia para mejor toma de decisiones. La finalidad de este trabajo de investigación es aplicar herramientas útiles para la empresa y a su vez para empresas que crean pertinente utilizarlos, que permitan facilitar el proceso de verificación de materiales, un correcto reconocimiento de obligación tributaria y la correcta elaboración de los Estados financieros ayudando a saber el estado actual en la que se encuentra, de tal forma que ayude a mejorar los procesos contables en la empresa.The Constructora P.A. Peru S.A.C. It is a company dedicated to the field of engineering projects, which provides horizontal drilling services and internal installation services of natural gas, the latter being the most important. The need for this investigation originates in the lack of knowledge of the workers involved in the Project of internal facilities and the warehouse area since there is no adequate communication with the accounting department. When observing this problem, we look for a correct application of the information in the relevant areas, which are: 1- Train accounting personnel to better understand the costs and expenses of inventories. 2- Design the appropriate sales record for the correct determination of the tax obligation for the sale of VAT. 3- Properly report the determination of financial statements to management for better decision making. The purpose of this research is to apply useful tools for the company and, in turn, for companies that believe it is appropriate to use them to facilitate the process of material verification, correct recognition of tax liability and proper preparation of resources financial statements Help to know the current state in which it is located, in such a way that it helps to improve the accounting processes in the company.Trabajo de investigació

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Measurements of the pp → ZZ production cross section and the Z → 4ℓ branching fraction, and constraints on anomalous triple gauge couplings at √s = 13 TeV

Four-lepton production in proton-proton collisions, pp -> (Z/gamma*)(Z/gamma*) -> 4l, where l = e or mu, is studied at a center-of-mass energy of 13 TeV with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The ZZ production cross section, sigma(pp -> ZZ) = 17.2 +/- 0.5 (stat) +/- 0.7 (syst) +/- 0.4 (theo) +/- 0.4 (lumi) pb, measured using events with two opposite-sign, same-flavor lepton pairs produced in the mass region 60 4l) = 4.83(-0.22)(+0.23) (stat)(-0.29)(+0.32) (syst) +/- 0.08 (theo) +/- 0.12(lumi) x 10(-6) for events with a four-lepton invariant mass in the range 80 4GeV for all opposite-sign, same-flavor lepton pairs. The results agree with standard model predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZ. couplings at 95% confidence level: -0.0012 < f(4)(Z) < 0.0010, -0.0010 < f(5)(Z) < 0.0013, -0.0012 < f(4)(gamma) < 0.0013, -0.0012 < f(5)(gamma) < 0.0013

Activity and high-order effective connectivity alterations in Sanfilippo C patient-specific neuronal networks

Induced pluripotent stem cell (iPSC) technology has been successfully used to recapitulate phenotypic traits of several human diseases in vitro. Patient-specific iPSC-based disease models are also expected to reveal early functional phenotypes, although this remains to be proved. Here, we generated iPSC lines from two patients with Sanfilippo type C syndrome, a lysosomal storage disorder with inheritable progressive neurodegeneration. Mature neurons obtained from patient-specific iPSC lines recapitulated the main known phenotypes of the disease, not present in genetically corrected patient-specific iPSC-derived cultures. Moreover, neuronal networks organized in vitro from mature patient-derived neurons showed early defects in neuronal activity, network-wide degradation, and altered effective connectivity. Our findings establish the importance of iPSC-based technology to identify early functional phenotypes, which can in turn shed light on the pathological mechanisms occurring in Sanfilippo syndrome. This technology also has the potential to provide valuable readouts to screen compounds, which can prevent the onset of neurodegeneration

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial

Background A vaccine against HIV is widely considered the most effective and sustainable way of reducing new infections. We evaluated the safety and impact of boosting with subtype C CN54rgp140 envelope protein adjuvanted in glucopyranosyl lipid adjuvant (GLA-AF) in Tanzanian volunteers previously given three immunizations with HIV-DNA followed by two immunizations with recombinant modified vaccinia virus Ankara (HIV-MVA). Methods Forty volunteers (35 vaccinees and five placebo recipients) were given two CN54rgp140/GLA-AF immunizations 30-71 weeks after the last HIV-MVA vaccination. These immunizations were delivered intramuscularly four weeks apart. Results The vaccine was safe and well tolerated except for one episode of asymptomatic hypoglycaemia that was classified as severe adverse event. Two weeks after the second HIV-MVA vaccination 34 (97%) of the 35 previously vaccinated developed Env-specific binding antibodies, and 79% and 84% displayed IFN-gamma ELISpot responses to Gag and Env, respectively. Binding antibodies to subtype C Env (included in HIV-DNA and protein boost), subtype B Env (included only in HIV-DNA) and CRF01_AE Env (included only in HIV-MVA) were significantly boosted by the CN54rgp140/GLA-AF immunizations. Functional antibodies detected using an infectious molecular clone virus/peripheral blood mononuclear cell neutralization assay, a pseudovirus/TZM-bl neutralization assay or by assays for antibody-dependent cellular cytotoxicity (ADCC) were not significantly boosted. In contrast, T-cell proliferative responses to subtype B MN antigen and IFN-gamma ELISpot responses to Env peptides were significantly enhanced. Four volunteers not primed with HIV-DNA and HIV-MVA before the CN54rgp140/ GLA-AF immunizations mounted an antibody response, while cell-mediated responses were rare. After the two Env subtype C protein immunizations, a trend towards higher median subtype C Env binding antibody titers was found in vaccinees who had received HIV-DNA and HIV-MVA prior to the two Env protein immunizations as compared to unprimed vaccinees (p = 0.07). Conclusion We report excellent tolerability, enhanced binding antibody responses and Env-specific cell-mediated immune responses but no ADCC antibody increase after two immunizations with a subtype C rgp140 protein adjuvanted in GLA-AF in healthy volunteers previously immunized with HIV-DNA and HIV-MVA

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines. Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) or the presentation of cell membrane bound gp150 envelopes (TMV01) from infected cells, and an additional two boosts with 5 μg of CN54gp140 protein adjuvanted with glucopyranosyl lipid adjuvant (GLA). Env immunogen sequences in UK003SG were solely based on the clade C isolate CN54, whereas in TMV01 these were based on clades A, C, B, and CRF01AE. The peptide microarray included 8 globally representative Env sequences, CN54gp140 and the MVA-encoded Env immunogens from both trials, as well as additional peptide variants for hot spots of immune recognition. Results: After the second MVA boost, UK003SG vaccinees almost exclusively targeted linear, non-glycosylated antigenic regions located in the inter-gp120 interface. In contrast, TMV01 recipients most strongly targeted the V2 region and an immunodominant region in gp41. The V3 region was frequently targeted in both trials, with a higher recognition magnitude for diverse antigenic variants observed in the UK003SG (p < 0.0001). After boosting with CN54gp140/GLA, the overall response magnitude increased with a more comparable recognition pattern of antigenic regions and variants between the two trials. Recognition of most immunodominant regions within gp120 remained significantly stronger in UK003SG, whereas V2-region recognition was not boosted in either group. Conclusions: IgG recognition of linear antigenic Env regions differed between the two trials particularly after the second MVA boost. Structural features of the MVA-encoded immunogens, such as secreted, monomeric gp120 vs. membrane-anchored, functional gp150, and differences in prime-boost immunogen sequence variability most probably contributed to these differences. Prime-boosting with multivalent Env immunogens during TMV01 did not improve variant cross-recognition of immunodominant peptide variants in the V3 region