Tate Modern Switch House

https://openscholarship.wustl.edu/bcs/1353/thumbnail.jp

New Concrete House

The property adjoins on three sides to existing and new constructions, while to the downhill side it’s attached at the access road and above it provides free views to the Lake Maggiore and to the mountains. The cleareasy-cut volumetry and also the naturalistic materializing of the concrete in the same colour like the natural rocks, integrates the new building with caution in the heterogeneous area. Concrete gets the natural stone of the modern era.https://openscholarship.wustl.edu/bcs/1176/thumbnail.jp

Parrish Art Museum

Material of interest: Concrete. Material used: Glass and Glazing: Westhampton Architectural Glass; Tile: Lido Stone Works; Wood Flooring: Bayshore Wood Flooring Properties of material: The reserved design is respectful of the landscape and channels the natural beauty through crisp forms and simple materials, while preserving the artistic legacy of the museum.https://openscholarship.wustl.edu/bcs/1092/thumbnail.jp

Elbphilharmonie Hamburg

https://openscholarship.wustl.edu/bcs/1398/thumbnail.jp

Caixa Forum

Material of interest: Cast iron panels, embossed metal mesh. Material used: Iron panels. Properties of material: Cast Iron Panels were digitally fabricated with a patterned cut out to let light into the top levels.https://openscholarship.wustl.edu/bcs/1015/thumbnail.jp

Messe Basel New Hall

Homogeneous material (aluminum) is the over all exterior surfaces. The facade of articulated twisting bands strategically modulates and reduces the scale of the large exhibition volumes to its surroundings.https://openscholarship.wustl.edu/bcs/1248/thumbnail.jp

Library of the Eberswalde Technical School

The molds used for the precast panels were lined with material which was dot-screened by acid etching, pixle by pixle, to duplicate historical photos from the collection of photographer Thomas Ruff which depict German life. The images are repeated along a band around the building.https://openscholarship.wustl.edu/bcs/1151/thumbnail.jp

Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity

Aging causes chronic low-grade inflammation known as inflamm-aging. It is a risk factor for chronic myelomonocytic leukemia (CMML), a hematological malignancy that is most prevalent in older people. Recent studies suggest a critical role for the NLRP3 inflammasome in inflamm-aging. However, the mechanisms involved in NLRP3 activation in aging and its involvement in CMML progression are not fully understood. Here, we report that aging increases interleukin-1β production upon NLRP3 activation in human CD14+ monocytes. Interestingly, we found that Toll-like receptor (TLR) 1/2 agonist Pam3Cysk4 directly activates NLRP3 inflammasome without the requirement of second activation signal in monocytes from older but not from younger healthy donors. Further, we observed a dichotomous response to NLRP3 inflammasome activation in monocytes from CMML patients. Intriguingly, CMML patients with heightened NLRP3 activation showed increased treatment dependency and disease severity. Collectively, our results suggest that aging causes increased sensitivity to NLRP3 inflammasome activation at cellular level, which may explain increased inflammation and immune dysregulation in older individuals. Furthermore, NLRP3 inflammasome activation was dysregulated in CMML and positively correlated with disease severity

Description abrégée de l'état présent de la Caroline méridionale

Sur la fondation de Purrysbourg

Forum Building and Plaza

The view is of an apex of the triangular shaped building. Pillars underneath creating an open public space are also visible