La ciencia de las redes

Obra ressenyada: D. J. WATTS, Six Degrees : the Science of a Connected Ag

Direct numerical simulations of mass transfer in square microchannels for liquid-liquid slug flow

Microreactors for the development of liquid-liquid processes are promising technologies since they are supposed to offer an enhancement of mass transfer compared to conventional devices due to the increase of the surface/volume ratio. But impact of the laminar flow should be negative and the effect is still to be evaluated. The present work focuses on the study of mass transfer in microchannels by means of 2D direct numerical simulations. We investigated liquid-liquid slug flow systems in square channel of 50 to 960 μm depth. The droplets velocity ranges from 0.0015 to 0.25 m/s and the ratio between the channel depth and the droplets length varies between 0.4 and 11.2. Droplet side volumetric mass transfer coefficients were identified from concentration field computations and the evolution of these coefficients as a function of the flow parameters and the channel size is discussed. This study reveals that mass transfer is strongly influenced by the flow structure inside the droplet. Moreover, it shows that the confinement of the droplets due to the channel size leads to an enhancement of mass transfer compared to cases where the droplets are not constrained by the walls

Modeling non-thermal emission from stellar bow shocks

Runaway O- and early B-type stars passing throughout the interstellar medium at supersonic velocities and characterized by strong stellar winds may produce bow shocks that can serve as particle acceleration sites. Previous theoretical models predict the production of high energy photons by non-thermal radiative processes, but their efficiency is still debated. We aim to test and explain the possibility of emission from the bow shocks formed by runaway stars traveling through the interstellar medium by using previous theoretical models. We apply our model to AE Aurigae, the first reported star with an X-ray detected bow shock, to BD+43 3654, in which the observations failed in detecting high energy emission, and to the transition phase of a supergiant star in the late stages of its life.From our analysis, we confirm that the X-ray emission from the bow shock produced by AE Aurigae can be explained by inverse Compton processes involving the infrared photons of the heated dust. We also predict low high energy flux emission from the bow shock produced by BD+43 3654, and the possibility of high energy emission from the bow shock formed by a supergiant star during the transition phase from blue to red supergiant.Bow shock formed by different type of runaway stars are revealed as a new possible source of high energy photons in our neighbourhood

Spatial distribution of X-ray emitting ejecta in Tycho's SNR: indications of shocked Titanium

Young supernova remnants show a characteristic ejecta-dominated X-ray emission that allows us to probe the products of the explosive nucleosynthesis processes and to ascertain important information about the physics of the supernova explosions. Hard X-ray observations have recently revealed the radioactive decay lines of 44Ti at ~67.9 keV and ~78.4 keV in the Tycho's SNR. We here analyze the set of XMM-Newton archive observations of the Tycho's SNR. We produce equivalent width maps of the Fe K and Ca XIX emission lines and find indications for a stratification of the abundances of these elements and significant anisotropies. We then perform a spatially resolved spectral analysis by identifying five different regions characterized by high/low values of the Fe K equivalent width. We find that the spatial distribution of the Fe K emission is correlated with that of the Cr XXII. We also detect the Ti K-line complex in the spectra extracted from the two regions with the highest values of the Fe and Cr equivalent widths. The Ti line emissions remains undetected in regions where the Fe and Cr equivalent widths are low. Our results indicate that the post-shock Ti is spatially co-located with other iron-peak nuclei in Tycho's SNR, in agreement with the predictions of multi-D models of Type Ia supernovae.Comment: Accepted for publication in Ap

Mixing characterization inside microdroplets engineered on a microcoalescer

We use a microdevice where microdroplets of reagents are generated and coalesce in a carrier continuous phase. The work focuses on the characterization of the mixing step inside the droplets, in the perspective to use them for chemical kinetic data acquisition. A dye and water are used, and an acid–base instantaneous chemical reaction is monitored thanks to a colored indicator. Acquisitions are done with a high-speed camera coupled to a microscope and a mixing parameter is calculated by image analysis. Different angles of bended channels and different ways of coalescence are compared. It is shown that the homogenization of the droplets can be reached in less than 10 ms after coalescence. This is achieved by forcing the droplets to coalesce in a “shifted” way, and later by adding 45◦ angle bends along the channel

An X-ray characterization of the central region of the SNR G332.5-5.6

We present an X-ray analysis of the central region of supernova remnant (SNR) G332.5-5.6 through an exhaustive analysis of XMM-Netwon observations with complementary infrared observations. We characterize and discuss the origin of the observed X-ray morphology, which presents a peculiar plane edge over the west side of the central region. The morphology and spectral properties of the X-ray supernova remnant were studied using a single full frame XMM-Newton observation in the 0.3 to 10.0 keV energy band. Archival infrared WISE observations at 8, 12 and 24 \mu m were also used to investigate the properties of the source and its surroundings at different wavelengths. The results show that the extended X-ray emission is predominantly soft (0.3-1.2 keV) and peaks around 0.5 keV, which shows that it is an extremely soft SNR. X-ray emission correlates very well with central regions of bright radio emission. On the west side the radio/X-ray emission displays a plane-like feature with a terminal wall where strong infrared emission is detected. Our spatially resolved X-ray spectral analysis confirms that the emission is dominated by weak atomic emission lines of N, O, Ne, and Fe, all of them undetected in previous X-ray studies. These characteristics suggest that the X-ray emission is originated in an optically thin thermal plasma, whose radiation is well fitted by a non-equilibrium ionization collisional plasma (VNEI) X-ray emission model. Our study favors a scenario where G332.5-5.6 is expanding in a medium with an abrupt density change (the wall), likely a dense infrared emitting region of dust on the western side of the source.Comment: 7 pages, 5 figures and 2 tables. Accepted for publication in A&

Software de Genealogías

Teniendo como antecedente la elaboración de un trabajo analítico centrado en el vínculo parentesco-posesión de ganado en la reserva patagónica tehuelche del Chalía, en el sur argentino, tuvimos como meta la automatización de las complejas tareas de carga de información que antes habíamos ejecutado manualmente. El resultado de esta preocupación es el programa que presentamos, que consta básicamente de un módulo de carga de datos parentales, capaz de mapear en diagramas arbolados las relaciones de descendencia que ligan a los miembros de una comunidad, y un módulo de generación de una matriz relacional procesable directamente por programas de ARS como el UCINET y PAJEK. Las diferentes representaciones generadas pueden almacenarse tanto en archivos de Excel como en archivos de texto con formato nativo directamente compatible con los programas nombrados, lo cual permite una extrapolación directa y sin intervención humana de la información ingresada por la interfase de carga. El desarrollo de esta aplicación nos otorga varias ventajas por sobre los métodos manuales de volcado de información. El proceso es mucho más veloz, consistente y confiable que apelando al ingreso manual, y además se pueden recorrer y modificar los datos de manera completamente intuitiva y clara, sin luchar con las dificultades inherentes a la interacción directa con la base de datos en su formato relacional. Además, la alimentación de información realizada por esta vía se desarrolla echando mano a la misma semántica del problema que se quiere analizar, cosa imposible de hacer si el usuario ejecuta la carga en la interfase del software final especializado en manejo de ARS

Detailed study of SNR G306.3-0.9 using XMM-Newton and Chandra observations

We used combined data from XMM-Newton and Chandra observatories to study the X-ray morphology of SNR G306.3-0.9. A spatially-resolved spectral analysis was used to obtain physical and geometrical parameters of different regions of the remnant. Spitzer infrared observations were also used to constrain the progenitor supernova and study the environment in which the SNR evolved. The X-ray morphology of the remnant displays a non-uniform structure of semi-circular appearance, with a bright southwest region and very weak or almost negligible X-ray emission in its northern part. These results indicate that the remnant is propagating in a non-uniform environment as the shock fronts are encountering a high-density medium, where enhanced infrared emission is detected. The X-ray spectral analysis of the selected regions shows distinct emission-line features of several metal elements, confirming the thermal origin of the emission. The X-ray spectra are well represented by a combination of two absorbed thermal plasma models: one in equilibrium ionization with a mean temperature of ~0.19 keV, and another out of equilibrium ionization at a higher temperature of ~1.1 or 1.6-1.9 keV. For regions located in the northeast, central, and southwest part of the SNR, we found elevated abundances of Si, S, Ar, Ca, and Fe, typical of ejecta material. The outer regions located northwest and south show values of the abundances above solar but lower than to those found in the central regions. This suggests that the composition of the emitting outer parts of the SNR is a combination of ejecta and shocked material of the interstellar medium. The comparison between the S/Si, Ar/Si, and Ca/Si abundances ratios (1.75, 1.27, and 2.72 in the central region, respectively), favor a Type Ia progenitor for this SNR, a result that is also supported by an independent morphological analysis using X-ray and IR data.Comment: 8 pages, 7 figures. Accepted by Astronomy and Astrophysic

Optimisation of operating conditions in batch for more sustainable continuous process transposition

Implementation of exothermic and fast reactions requires a perfect temperature control to avoid thermal runaway and in most cases to limit by-products production. In order to fit with the heat removal capacity of common devices, expensive strategies are currently used to slow down this kind of reactions in order to avoid a strong temperature increase such as reactants dilution. Within the concept of process intensification, industries could move towards more sustainable process by reducing technology constraints to the benefit of chemistry. For that purpose, a two-step methodology is implemented. The first step consists in the optimisation of the operating conditions only based on stoichio-chemical scheme and kinetic laws. This is carried out by adjusting temperature profile and feeding rate strategy in a batch operation. Then a design for a continuous process is proposed, trying to approach the optimal batch operating conditions. This methodology is applied to the linear alkylbenzene sulfonation

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models.

Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models. In humans with Duchenne muscular dystrophy treated with AOs, low levels of dystrophin have been induced, and modest slowing of disease progression has been observed, highlighting the need for improved efficiency of human skipping drugs. Here, we demonstrate that dantrolene and Rycals S107 and ARM210 potentiate AO-mediated exon skipping of exon 44 or exon 45 in patient-derived myotube cultures with appropriate mutations. Further, dantrolene is shown to boost AO-mediated exon skipping in patient-derived, induced cardiomyocyte cultures. Our findings further validate the ryanodine receptors (RyR) as the likely target responsible for exon skip boosting and demonstrate potential applicability beyond exon 51 skipping. These data provide preclinical support of dantrolene trial as an adjuvant to AO-mediated exon-skipping therapy in humans and identify a novel Rycal, ARM210, for development as a potential exon-skipping booster. Further, they highlight the value of mutation-specific DMD culture models for basic discovery, preclinical drug screening and translation of personalized genetic medicines