Spheromak Experiment Using Separate Guns For Formation And Sustainment

An experiment is described that incorporates the use of separate magnetized plasma guns for formation and sustainment of a spheromak. It is shown that energy coupling efficiency approaches unity if the gun and spheromak are of comparable size. A large gun should be able to operate at lower current and therefore lower voltage. In addition, it is expected that a gun matched to the size of the spheromak will cause less perturbation to the equilibrium. It is proposed to use a smaller gun for spheromak formation and a large, efficient gun for sustainment. The theoretical basis for the experiment is developed, and the details of the experiment are described. A prediction of the equilibrium magnetic flux surfaces using the EFIT code is presented

Coherent States for Unusual Potentials

The program to construct minimum-uncertainty coherent states for general potentials works transparently with solvable analytic potentials. However, when an analytic potential is not completely solvable, like for a double-well or the linear (gravitational) potential, there can be a conundrum. Motivated by supersymmetry concepts in higher dimensions, we show how these conundrums can be overcome.Comment: 10 pages, 3 figures, added info in Ref.

Influence of wear algorithm formulation on computational-experimental corroboration

Experimental wear testing is well-established as an important part of the TKR design process. Recently, in-silico models have proved their value to corroborate long-term in-vitro results on a much shorter timescale [1]. Both FE-based models & multi-body dynamics can be used to predict contact pressures, sliding distances and cross-shear (CS). The precise mechanisms of wear are not sufficiently understood to permit analytical calculations, and so empirical formulations are used to estimate wear depths & volumes.Most early simulations were based on a modified Archard/Lancaster formulation; more recently a number of alternative formulations for cross shear have been proposed; it is unclear which is the most robust or accurate for the widest range of activities. The aim of this study was to develop and corroborate a fast in-silico wear model, and use this to compare different wear formulations

Whirling skirts and rotating cones

Steady, dihedrally symmetric patterns with sharp peaks may be observed on a spinning skirt, lagging behind the material flow of the fabric. These qualitative features are captured with a minimal model of traveling waves on an inextensible, flexible, generalized-conical sheet rotating about a fixed axis. Conservation laws are used to reduce the dynamics to a quadrature describing a particle in a three-parameter family of potentials. One parameter is associated with the stress in the sheet, aNoether is the current associated with rotational invariance, and the third is a Rossby number which indicates the relative strength of Coriolis forces. Solutions are quantized by enforcing a topology appropriate to a skirt and a particular choice of dihedral symmetry. A perturbative analysis of nearly axisymmetric cones shows that Coriolis effects are essential in establishing skirt-like solutions. Fully non-linear solutions with three-fold symmetry are presented which bear a suggestive resemblance to the observed patterns.Comment: two additional figures, changes to text throughout. journal version will have a wordier abstrac

Many-to-One Boundary Labeling with Backbones

In this paper we study \emph{many-to-one boundary labeling with backbone leaders}. In this new many-to-one model, a horizontal backbone reaches out of each label into the feature-enclosing rectangle. Feature points that need to be connected to this label are linked via vertical line segments to the backbone. We present dynamic programming algorithms for label number and total leader length minimization of crossing-free backbone labelings. When crossings are allowed, we aim to obtain solutions with the minimum number of crossings. This can be achieved efficiently in the case of fixed label order, however, in the case of flexible label order we show that minimizing the number of leader crossings is NP-hard.Comment: 23 pages, 10 figures, this is the full version of a paper that is about to appear in GD'1

Corepressor diversification by alternative mRNA splicing is species specific.

BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors. The functions of both corepressors are extensively diversified in mice by alternative mRNA splicing, generating a series of protein variants that differ in different tissues and that exert different, even diametrically opposite, biochemical and biological effects from one another.ResultsWe report here that the alternative splicing previously reported for SMRT appears to be a relatively recent evolutionary phenomenon, with only one of these previously identified sites utilized in a teleost fish and a limited additional number of the additional known sites utilized in a bird, reptile, and marsupial. In contrast, extensive SMRT alternative splicing at these sites was detected among the placental mammals. The alternative splicing of NCoR previously identified in mice (and shown to regulate lipid and carbohydrate metabolism) is likely to have arisen separately and after that of SMRT, and includes an example of convergent evolution.ConclusionsWe propose that the functions of both SMRT and NCoR have been diversified by alternative splicing during evolution to allow customization for different purposes in different tissues and different species

Dipoles in thin sheets

A flat elastic sheet may contain pointlike conical singularities that carry a metrical "charge" of Gaussian curvature. Adding such elementary defects to a sheet allows one to make many shapes, in a manner broadly analogous to the familiar multipole construction in electrostatics. However, here the underlying field theory is non-linear, and superposition of intrinsic defects is non-trivial as it must respect the immersion of the resulting surface in three dimensions. We consider a "charge-neutral" dipole composed of two conical singularities of opposite sign. Unlike the relatively simple electrostatic case, here there are two distinct stable minima and an infinity of unstable equilibria. We determine the shapes of the minima and evaluate their energies in the thin-sheet regime where bending dominates over stretching. Our predictions are in surprisingly good agreement with experiments on paper sheets.Comment: 20 pages, 5 figures, 2 table

Identification of putative steroid receptor antagonists in bottled water : combining bioassays and high-resolution mass spectrometry

Endocrine disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling and thereby adversely affecting human health. Recent reports provide evidence for the presence of EDCs in commercially available bottled water, including steroid receptor agonists and antagonists. However, since these findings are based on biological data the causative chemicals remain unidentified and, therefore, inaccessible for toxicological evaluation. Thus, the aim of this study is to assess the antiestrogenic and antiandrogenic activity of bottled water and to identify the causative steroid receptor antagonists. We evaluated the antiestrogenic and antiandrogenic activity of 18 bottled water products in reporter gene assays for human estrogen receptor alpha and androgen receptor. Using nontarget high-resolution mass spectrometry (LTQ-Orbitrap Velos), we acquired corresponding analytical data. We combined the biological and chemical information to determine the exact mass of the tentative steroid receptor antagonist. Further MS(n) experiments elucidated the molecule's structure and enabled its identification. We detected significant antiestrogenicity in 13 of 18 products. 16 samples were antiandrogenic inhibiting the androgen receptor by up to 90%. Nontarget chemical analysis revealed that out of 24520 candidates present in bottled water one was consistently correlated with the antagonistic activity. By combining experimental and in silico MS(n) data we identified this compound as di(2-ethylhexyl) fumarate (DEHF). We confirmed the identity and biological activity of DEHF and additional isomers of dioctyl fumarate and maleate using authentic standards. Since DEHF is antiestrogenic but not antiandrogenic we conclude that additional, yet unidentified EDCs must contribute to the antagonistic effect of bottled water. Applying a novel approach to combine biological and chemical analysis this is the first study to identify so far unknown EDCs in bottled water. Notably, dioctyl fumarates and maleates have been overlooked by science and regulation to date. This illustrates the need to identify novel toxicologically relevant compounds to establish a more holistic picture of the human exposome