333 research outputs found

    Seasonal influences on first-episode admission in affective and non-affective psychosis

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    Background: Since bipolar affective disorder has been recorded, clinicians treating patients with this disorder have noted the cyclic nature of episodes, particularly an increase in mania in the spring and summer months and depression during winter. Objective: The aim of this study was to investigate seasonality in symptom onset and service admissions over a period of 10 years in a group of patients (n= 359) with first-episode (FE) mania (n= 133), FE schizoaffective disorder (n= 49) and FE schizophrenia (n= 177). Method: Patients were recruited if they were between 15 and 28 years of age and if they resided in the geographical mental health service catchment area. The number of patients experiencing symptom onset and service admission over each month and season was recorded. Results: In terms of seasonality of time of service admission, the results indicate a high overall seasonality (particularly in men), which was observed in both the schizoaffective and the bipolar groups. In terms of seasonality of symptom onset, the results indicate that seasonality remains in the male bipolar group, but other groups have no seasonal trend. Conclusions: This provides further evidence that systems mediating the entrainment of biological rhythms to the environment may be more pronounced in BPAD than in schizoaffective disorder and schizophrenia. These results may help facilitate the preparedness of mental heath services for patients at different times of the yea

    Genetic diversity and population structure among six cattle breeds in South Africa using a whole genome SNP panel

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    Information about genetic diversity and population structure among cattle breeds is essential for genetic improvement, understanding of environmental adaptation as well as utilization and conservation of cattle breeds. This study investigated genetic diversity and the population structure among six cattle breeds in South African (SA) including Afrikaner (n=44), Nguni (n=54), Drakensberger (n=47), Bonsmara (n=44), Angus (n=31) and Holstein (n=29). Genetic diversity within cattle breeds was analyzed using three measures of genetic diversity namely allelic richness (AR), expected heterozygosity (He) and inbreeding coefficient (f). Genetic distances between breed pairs were evaluated using Nei’s genetic distance. Population structure was assessed using model-based clustering (ADMIXTURE). Results of this study revealed that the allelic richness ranged from 1.88 (Afrikaner) to 1.73 (Nguni). Afrikaner cattle had the lowest level of genetic diversity (He=0.24) and the Drakensberger cattle (He=0.30) had the highest level of genetic variation among indigenous and locally-developed cattle breeds. The level of inbreeding was lower across the studied cattle breeds. As expected the average genetic distance was the greatest between indigenous cattle breeds and Bos taurus cattle breeds but the lowest among indigenous and locally-developed breeds. Model-based clustering revealed some level of admixture among indigenous and locally-developed breeds and supported the clustering of the breeds according to their history of origin. The results of this study provided useful insight regarding genetic structure of South African cattle breeds

    Genetic Correlations Among Sex-Limited Traits

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    Monte Carlo simulation techniques were used to assess the merits of three methods for calculation of the genetic correlation when traits have been measured on half-sibs of each sex. The restricted maximum likelihood, path coefficient and covariance component estimators did not differ significantly in their accuracy. Path coefficient and covariance component methodologies gave nearly unbiased estimators for traits of high heritability. Across both levels of heritability, the restricted maximum likelihood methodology resulted in genetic correlations being estimated with significantly smaller sampling variance than the other methods. Genetic correlations were estimated for age of puberty, weight at puberty, conceptions per service, gestation length, calving difficulty, progeny birth weight, progeny preweaning daily gain and mature weight measured on females, with postweaning daily gain, carcass weight, fat trim weight, and retail product weight measured on male half-sibs. Correlations of the female traits with postweaning daily gain, carcass weight, and retail product weight generally were similar to each other. Correlations of fat trim weigh with the female traits were similar in magnitude and opposite in sign to the correlations of postweaning daily gain, carcass weight, and retail product weight with the female traits. Predicted correlated responses to one phenotypic standard deviation of selection for increased postweaning daily gain were increased age at puberty 3.39 days, weight at puberty 1.02 kg, dam’s progeny birth weight .50 kg and mature weight 1.45 kg and reduced g station length .20 days and the frequency of calving difficulty .07 percent. The estimated genetic correlations of postweaning daily gain of the dam’s steer half-sibs with conceptions per service and dam’s progeny preweaning daily gain had absolute values greater than one and were positive and negative, respectively. Predicted correlated responses to one phenotypic standard deviation of selection for reduced fat trim weight at a constant age were increased age at puberty 7.22 days, weight at puberty 5.29 kg, gestation length .17 days, the frequency of calving difficulty .05 percent, birth weight, .12 kg and mature weight .22 kg and decreased conceptions per service .01 units. The estimated genetic correlation of age constant fat trim weigh with dam’s progeny preweaning daily gain was less than negative one

    Putative Loci Causing Early Embryonic Mortality in Duroc Swine

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    Lethal recessive alleles that act prenatally may be detected from the absence of homozygous individuals in a population. However, these alleles may be maintained at relatively low frequencies in populations as heterozygotes. In pigs, they may reduce litter size. This study aimed to detect putative lethal variants in the Duroc breed. Phenotypes for the numbers of piglets born (TNB), born live (BA), alive at 24 h (L24), stillborn (SB), and born as mummified fetuses (MM) were available from 5340 recorded litters which resulted from mating of 192 genotyped boars with sows of unknown genotype (dataset 1). An additional 50 litters were produced from parents that were both genotyped (dataset 2). Imputed genotypes of 650K SNPs for 1359 Duroc boars were used in this study. One significant SNP (Bonferroni corrected P = 5.5E-06) was located on SSC14 with 45.3 homozygous individuals expected but none observed. This SNP was significant for mummified fetuses. One hundred fifty two haplotypes were also found to potentially harbor recessive lethal mutations. Twenty-one haplotypes had a significant harmful effect on at least one trait. Two regions, located on SSC8 (144.9–145.5 Mb) and SSC9 (19–19.4 Mb) had significant effects on fertility traits in both datasets. Additionally, regions on SSC1 (82.0–82.8 Mb), SSC3 (73.3–73.7 and 87.1–87.5 Mb) and SSC12 (35.8–36.2 and 50.0–50.5 Mb) had significant deleterious effects on TNB or BA or L24 in dataset 1. Finally, a region on SSC17 (28.7–29.3 Mb) had significant effects on TNB, BA and L24 in dataset 2. A few candidate genes identified within these regions were described as being involved in spermatogenesis and male fertility (TEX14, SEP4, and HSF5), or displayed recessive lethality (CYP26B1, SCD5, and PCF11) in other species. The putative loci detected in this study provide valuable information to potentially increase Duroc litter size by avoiding carrier-by-carrier matings in breeding programs. Further study of the identified candidate genes responsible for such lethal effects may lead to new insights into functions regulating pig fertility

    Genetic Correlations of Reproductive and Maternal Traits with Growth and Carcass Traits in Beef Cattle

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    Some genes may affect more than one trait. Therefore, the traits can be genetically correlated. Knowledge of genetic correlations among traits is useful for efficient selection of replacement bulls and heifers if the breeder considers more than one trait. In designed selection programs, emphasis to be placed on the various traits can depend, in part, on the genetic correlations among them. In addition, genetic correlations can be used to predict what is expected to happen to traits other than those used in selection as a result of that selection. This effect on traits other than those used in selection is referred to as correlated response. The objective of this study was to estimate from experimental data the genetic correlations between reproductive and maternal traits of beef females and growth and carcass traits of paternal half-sib steers. A more detailed account of the methodology and results can be found in the Journal of Animal Science, volume 58, pages 1171 to 1180

    Using Crossbreeding Systems to Produce Beef

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    Crossbreeding provides an opportunity to improve performance by beef cattle. Breed differences are heritable and can be used to produce superior crossbred cattle. Heterosis results from bringing together unlike genes from different breeds to produce an animal with a level of performance that exceeds the average of the parent breeds. We develop crossbreeding systems to make the greatest improvement in performance possible consistent with a sustainable breeding program. Heterosis and differences among breeds are tools of the trade. In this paper, we combine the results from earlier studies to investigate their practical applications

    Development of Terminal and Maternal Economic Selection Indices in Beefmaster Cattle

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    Two economic selection indices were developed for Beefmaster cattle, one for a terminal objective and one for a maternal objective. The terminal index was developed assuming bulls would be mated to mature cows with all resulting progeny harvested. The maternal index was developed assuming bulls would be mated to a combination of heifers and mature cows, with resulting progeny retained as replacements or sold at weaning. Relative economic values for the terminal objective traits hot carcass weight, marbling score, ribeye area, 12th- rib fat and feed intake were 91.29, 17.01, 8.38,- 7.07 and- 29.66, respectively. Relative economic values for the maternal objective traits calving difficultly direct, calving difficulty maternal, weaning weight direct, weaning weight maternal, mature weight and heifer pregnancy were- 2.11,- 1.53, 18.49, 11.28,- 33.46 and 1.19, respectively. The application of economic selection indices facilitates genetic improvement of beef cattle by aiding producers with their sire selection decisions

    Bringing 'place' back in: regional clusters, project governance, and new product outcomes

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    We examine new product outcomes in the context of regional clusters. Based on past research on marketing relationships, clusters, and social networks, we propose that the overall configuration of a cluster helps promote particular governance practices among its members. These practices have distinct value-creating properties, and when they are brought to bear on a specific new product development project within a cluster, they promote performance outcomes like product novelty and speed to market. Ultimately, these performance effects are reinforced by the configuration of the cluster itself. In general, we propose that new product outcomes follow from complex interactions between a cluster's macro-level configuration and its micro-level governance processes. More broadly, our framework points to the importance of geographical variables and to the role of “place” in marketing decision-making

    Genetic Correlations of Reproductive and Maternal Traits with Growth and Carcass Traits in Beef Cattle

    Get PDF
    Some genes may affect more than one trait. Therefore, the traits can be genetically correlated. Knowledge of genetic correlations among traits is useful for efficient selection of replacement bulls and heifers if the breeder considers more than one trait. In designed selection programs, emphasis to be placed on the various traits can depend, in part, on the genetic correlations among them. In addition, genetic correlations can be used to predict what is expected to happen to traits other than those used in selection as a result of that selection. This effect on traits other than those used in selection is referred to as correlated response. The objective of this study was to estimate from experimental data the genetic correlations between reproductive and maternal traits of beef females and growth and carcass traits of paternal half-sib steers. A more detailed account of the methodology and results can be found in the Journal of Animal Science, volume 58, pages 1171 to 1180
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