Form follows function: pragmatic controlled trials (PCTs) have to answer different questions and require different designs than randomized controlled trials (RCTs).

Aim Rising concern for demonstrated real world comparative effectiveness has heightened interest in “pragmatic trials” design. Pragmatic trials investigate whether the efficacy, presumed or found in explanatory trials under ideal conditions, can also be detected under real world conditions, i.e. effectiveness. It is also recognized that ‘real world’ effects which are usually addressed in public health research gain growing interest in confirming the ‘road capability’ of results obtained under ideal study conditions. This paper demonstrates that studies under ideal or real world conditions use different methods, generate different information and cannot replace each other. Subjects and methods The PCT design meets four requirements of public health and of effectiveness research. It includes all individuals who presented with the selected condition. It classifies the included individuals according to baseline risks. It enables plausibility controls. Finally, it compares the outcomes resulting from specified and notspecified interventions or treatments. Proposal We propose a pragmatic controlled trial (PCT) design in which patient preference and other co-factors crucial in determining the actual effectiveness of interventional options will not be neutralized by concealed randomization and blinding. This design is applicable to record the selected interventions and generated outcomes in day-to-day health care and is capable of incorporating preference and other participative factors into assessment of effectiveness. Conclusions The PCT design is useful for public health research, e.g. the effectiveness of interventions to change smoking habits or to prevent death frombreast cancer, as well as for comparative effectiveness research where it will supplement the traditional randomized controlled trial (RCT)

Exploring Personality and Readiness to Change in Patients With Substance Use Disorders With and Without ADHD

Objective: To explore personality and readiness to change among substance use disorders (SUD) patients with and without ADHD. Method: SUD + ADHD versus SUD − ADHD patients consecutively entering treatment between 2010 and 2012 were compared concerning personality (Temperament and Character Inventory) and readiness to change (Stages of Change Readiness and Treatment Eagerness Scale). Results: Among 103 SUD patients (76 men, age M = 43.3, SD = 11.1), 16 (15.5%) were diagnosed with ADHD. SUD + ADHD patients reported significantly elevated eagerness to effort (p = .008) compared with SUD − ADHD patients, who reported significantly elevated fear of uncertainty (p Conclusion: The distinct characteristics found in SUD + ADHD and SUD − ADHD patients underline the need for differentiated treatment interventions.</p

RANRAC: Robust Neural Scene Representations via Random Ray Consensus

Learning-based scene representations such as neural radiance fields or light field networks, that rely on fitting a scene model to image observations, commonly encounter challenges in the presence of inconsistencies within the images caused by occlusions, inaccurately estimated camera parameters or effects like lens flare. To address this challenge, we introduce RANdom RAy Consensus (RANRAC), an efficient approach to eliminate the effect of inconsistent data, thereby taking inspiration from classical RANSAC based outlier detection for model fitting. In contrast to the down-weighting of the effect of outliers based on robust loss formulations, our approach reliably detects and excludes inconsistent perspectives, resulting in clean images without floating artifacts. For this purpose, we formulate a fuzzy adaption of the RANSAC paradigm, enabling its application to large scale models. We interpret the minimal number of samples to determine the model parameters as a tunable hyperparameter, investigate the generation of hypotheses with data-driven models, and analyze the validation of hypotheses in noisy environments. We demonstrate the compatibility and potential of our solution for both photo-realistic robust multi-view reconstruction from real-world images based on neural radiance fields and for single-shot reconstruction based on light-field networks. In particular, the results indicate significant improvements compared to state-of-the-art robust methods for novel-view synthesis on both synthetic and captured scenes with various inconsistencies including occlusions, noisy camera pose estimates, and unfocused perspectives. The results further indicate significant improvements for single-shot reconstruction from occluded images. Project Page: https://bennobuschmann.com/ranrac

LightGuider: Guiding Interactive Lighting Design using Suggestions, Provenance, and Quality Visualization

LightGuider is a novel guidance-based approach to interactive lighting design, which typically consists of interleaved 3D modeling operations and light transport simulations. Rather than having designers use a trial-and-error approach to match their illumination constraints and aesthetic goals, LightGuider supports the process by simulating potential next modeling steps that can deliver the most significant improvements. LightGuider takes predefined quality criteria and the current focus of the designer into account to visualize suggestions for lighting-design improvements via a specialized provenance tree. This provenance tree integrates snapshot visualizations of how well a design meets the given quality criteria weighted by the designer's preferences. This integration facilitates the analysis of quality improvements over the course of a modeling workflow as well as the comparison of alternative design solutions. We evaluate our approach with three lighting designers to illustrate its usefulness

Challenges and Unique Solutions to Rodent Eradication in Florida

Once established, invasive rodents cause significant impacts to island flora and fauna, including species extinctions. There have been numerous efforts to eradicate invasive rodents from islands worldwide, with many successes. For a number of reasons, many invasive vertebrates have become established in Florida, including several rodent species. We have implemented rodent eradication efforts on two Florida islands. Using the successful eradication strategy developed for Buck Island, U.S. Virgin Islands, we have attempted the eradication of roof rats from Egmont Key off Tampa Bay. We also are attempting to eradicate Gambian giant pouched rats from Grassy Key in the Florida Keys. On Egmont Key, we used a grid of bait stations containing diphacinone rodenticide bait blocks and hand tossing of bait blocks into thickets. On Grassy Key, we used a grid of bait stations containing a zinc phosphide bait along with intensive live-trapping. We discuss the eradication planning, efforts to minimize nontarget animal losses, and follow-up activities. We also discuss some of the difficulties encountered in each of these two different situations

Optimizing Apparent Display Resolution Enhancement for Arbitrary Videos

Display resolution is frequently exceeded by available image resolution. Recently, apparent display resolution enhancement techniques (ADRE) have demonstrated how characteristics of the human visual system can be exploited to provide super-resolution on high refresh rate displays. In this paper we address the problem of generalizing the apparent display resolution enhancement technique to conventional videos of arbitrary content. We propose an optimization-based approach to continuously translate the video frames in such a way that the added motion enables apparent resolution enhancement for the salient image region. The optimization takes the optimal velocity, smoothness and similarity into account to compute an appropriate trajectory. Additionally, we provide an intuitive user interface which allows to guide the algorithm interactively and preserve important compositions within the video. We present a user study evaluating apparent rendering quality and demonstrate versatility of our method on a variety of general test scenes.Aktuelle Kameras sind in der Lage, Videos mit sehr hoher Auflösung aufzunehmen (> 4K Pixel). Monitore, Fernseher und Projektoren haben jedoch meist eine deutlich niedrigere Auflösung (FullHD). Bei der Darstellung hochaufgelöster Videos auf diesen Geräten gehen durch das nötige Herrunterrechnen der Videodaten feine Details verloren, z.B. Haare oder die Pigmentierung von Oberflächenmaterialien. Es wird ein Verfahren präsentiert, welches die Darstellung eines beliebigen Videos mit einer Auflösung ermöglicht, die perzeptuell höher ist als die Auflösung des Ausgabegerätes

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

A wide array of sizes, ecosystems, cultures, and invasive wildlife are represented among inhabited islands. Here, six cases from the United States of America (US) are selected to illustrate the high diversity of invasive animal management issues and objectives. We outline the background, define the problems and management objectives. We identify the management approaches and discuss the results and influences as they specifically relate to inhabited islands. The examples are: (1) Gambian giant pouched rats on Grassy Key, Florida; (2) coqui frogs on Kaua’i, Hawai’i; (3) feral swine on Cayo Costa Island, Florida; (4) rodents and monitor lizards on Cocos Island, Guam; (5) black spiny-tailed iguanas (ctenosaurs) on Gasparilla Island, Florida; and (6) mongooses on Puerto Rico. The outcomes of the programs are discussed, particularly in relation to the impact of human habitation on success

Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Background Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. Methods Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (< 1, 1-4, 5-9, and 10-14 years, inclusive) using appropriate life tables. We estimated age-standardised net survival for international comparison of survival trends for precursor-cell acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). Findings We analysed data from 89 828 children from 198 registries in 53 countries. During 1995-99, 5-year agestandardised net survival for all lymphoid leukaemias combined ranged from 10.6% (95% CI 3.1-18.2) in the Chinese registries to 86.8% (81.6-92.0) in Austria. International differences in 5-year survival for childhood leukaemia were still large as recently as 2005-09, when age-standardised survival for lymphoid leukaemias ranged from 52.4% (95% CI 42.8-61.9) in Cali, Colombia, to 91.6% (89.5-93.6) in the German registries, and for AML ranged from 33.3% (18.9-47.7) in Bulgaria to 78.2% (72.0-84.3) in German registries. Survival from precursor-cell ALL was very close to that of all lymphoid leukaemias combined, with similar variation. In most countries, survival from AML improved more than survival from ALL between 2000-04 and 2005-09. Survival for each type of leukaemia varied markedly with age: survival was highest for children aged 1-4 and 5-9 years, and lowest for infants (younger than 1 year). There was no systematic difference in survival between boys and girls. Interpretation Global inequalities in survival from childhood leukaemia have narrowed with time but remain very wide for both ALL and AML. These results provide useful information for health policy makers on the effectiveness of health-care systems and for cancer policy makers to reduce inequalities in childhood survival

A Joint Approach Towards Data-Driven Virtual Testing for Automated Driving: The AVEAS Project

With growing complexity and responsibility of automated driving functions in road traffic and growing scope of their operational design domains, there is increasing demand for covering significant parts of development, validation, and verification via virtual environments and simulation models. If, however, simulations are meant not only to augment real-world experiments, but to replace them, quantitative approaches are required that measure to what degree and under which preconditions simulation models adequately represent reality, and thus allow their usage for virtual testing of driving functions. Especially in research and development areas related to the safety impacts of the "open world", there is a significant shortage of real-world data to parametrize and/or validate simulations - especially with respect to the behavior of human traffic participants, whom automated vehicles will meet in mixed traffic. This paper presents the intermediate results of the German AVEAS research project (www.aveas.org) which aims at developing methods and metrics for the harmonized, systematic, and scalable acquisition of real-world data for virtual verification and validation of advanced driver assistance systems and automated driving, and establishing an online database following the FAIR principles.Comment: 6 pages, 5 figures, 2 table

Developmental Basis of Shh Medulloblastoma Heterogeneity

Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hedgehog (SHH) activation could be due to differences in developmental pathways. To investigate this question, here we perform single-nucleus RNA sequencing on highly differentiated SHH MBs with extensively nodular histology and observed malignant cells resembling each stage of canonical granule neuron development. Through innovative computational approaches, we connect these results to published datasets and find that some established molecular subtypes of SHH MB appear arrested at different developmental stages. Additionally, using multiplexed proteomic imaging and MALDI imaging mass spectrometry, we identify distinct histological and metabolic profiles for highly differentiated tumors. Our approaches are applicable to understanding the interplay between heterogeneity and differentiation in other cancers and can provide important insights for the design of targeted therapies