Coagulation and anticoagulation in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events. Coagulation and fibrinolytic systems play central roles in wound healing and repair, processes hypothesised to be abnormal within the IPF lung. Animal models of pulmonary fibrosis have demonstrated an imbalance between thrombosis and fibrinolysis within the alveolar compartment, a finding that is also observed in IPF patients. A systemic prothrombotic state also occurs in IPF and is associated with increased mortality, but trials of anticoagulation in IPF have provided conflicting results. Differences in methodology, intervention and study populations may contribute to the inconsistent trial outcomes. The new oral anticoagulants have properties that may prove advantageous in targeting both thrombotic risk and progression of lung fibrosis

Navigating New Trade Routes: The rise of Value chains, and the Challenges for Canadian Trade Policy

In the new paradigm of international trade, Canada needs a trade policy that recognizes both the increasing importance of global value chains and the critical role of Canada-US commercial and regulatory integration in gaining full benefit from their exploitation.border papers, international policy

Should subsistence agriculture be supported as a strategy to address rural food insecurity?

At first glance South Africa’s black farming sector appears to contribute rather minimally to overall agricultural output in South Africa. However, despite the complexity involved in this sector and the often marginal conditions in which agriculture is practised it appears to be important to a large number of black households. Furthermore, the significance they attach to subsistence agriculture as means of supplementing household food supplies seems to heavily outweigh other reasons for engaging in agriculture. Some South African researchers have indicated the contribution subsistence production makes to household food security, despite the prevalent complexities and the low input nature of this production. Statistics South Africa’s Labour Force Survey data from 2001 to 2007 and a case study of subsistence farming in Limpopo Province are used to support the argument that, despite the complexity of this sector, the more than 4 million subsistence farmers, need and merit greater support. Such support should be based on the local context, build on and, where appropriate, improve existing local practices, while addressing various existing threats to this type of production. Recommendations are made as to what policy makers need to consider when considering how best to support subsistence production.subsistence production, Labour Force Survey, traditional crops, local agricultural practices, Consumer/Household Economics,

Helmet-mounted pilot night vision systems: Human factors issues

Helmet-mounted displays of infrared imagery (forward-looking infrared (FLIR)) allow helicopter pilots to perform low level missions at night and in low visibility. However, pilots experience high visual and cognitive workload during these missions, and their performance capabilities may be reduced. Human factors problems inherent in existing systems stem from three primary sources: the nature of thermal imagery; the characteristics of specific FLIR systems; and the difficulty of using FLIR system for flying and/or visually acquiring and tracking objects in the environment. The pilot night vision system (PNVS) in the Apache AH-64 provides a monochrome, 30 by 40 deg helmet-mounted display of infrared imagery. Thermal imagery is inferior to television imagery in both resolution and contrast ratio. Gray shades represent temperatures differences rather than brightness variability, and images undergo significant changes over time. The limited field of view, displacement of the sensor from the pilot's eye position, and monocular presentation of a bright FLIR image (while the other eye remains dark-adapted) are all potential sources of disorientation, limitations in depth and distance estimation, sensations of apparent motion, and difficulties in target and obstacle detection. Insufficient information about human perceptual and performance limitations restrains the ability of human factors specialists to provide significantly improved specifications, training programs, or alternative designs. Additional research is required to determine the most critical problem areas and to propose solutions that consider the human as well as the development of technology