Shift in weak phase γ\gamma due to CP asymmetries in DD decays to two pseudoscalar mesons

A difference of several tenths of a percent has been observed between the direct CP asymmetries of $D^0\to K^+K^-$ and $D^0\to \pi^+\pi^-$. It has been noted recently that CP asymmetries in such singly-Cabibbo-suppressed (SCS) decays can affect the determination of the weak phase $\gamma$ using the Gronau-London-Wyler method of comparing rates for $B^+ \to D K^+$ and $B^- \to D K^-$, where $D$ is a superposition of $D^0$ and \od decaying to a CP eigenstate. Using an analysis of the CP asymmetries in SCS decays based on a $c \to u$ penguin amplitude with standard model weak phase but enhanced by CP-conserving strong interactions, we estimate typical shifts in $\gamma$ of several degrees and pinpoint measurements which would reduce uncertainties to an acceptable level.Comment: 15 pages, 3 figures, submitted to Phys. Rev. D. More text and references adde

Measuring Strong and Weak Phases in Time-Independent B Decays

Flavor SU(3) symmetry implies certain relations among $B$-decay amplitudes to $\pi\pi$, $\pi K$ and $K {\bar K}$ final states, when annihilation-like diagrams are neglected. Using three triangle relations, we show how to measure the weak CKM phases $\alpha$ and $\gamma$ using time-independent rate measurements only. In addition, one obtains all the strong final-state phases and the magnitudes of individual terms describing tree (spectator), color-suppressed and penguin diagrams. Many independent measurements of these quantities can be made with this method, which helps to eliminate possible discrete ambiguities and to estimate the size of SU(3)-breaking effects.Comment: 2 figures available from the authors upon request, 12 pages,UdeM-LPN-TH-94-19

Ariel - Volume 2 Number 1

Editors Delvun C. Case, Jr. Paul M. Fernhoff Associate Editors Donald Bergman Daniel B. Gould Richard Bonanno Ronald Hoffman Lay-Out Editor Carol Dolinskas Sports Editor James Nocon Business Manager Nick Grego Contributing Editors Michael J. Blecker Stephen P. Flynn Lin Sey Edwards Jack Guralnik W. Cherry Ligh

Studying New Physics Amplitudes in Charmless B_s Decays

A method based on flavour SU(3) is proposed for identifying and extracting New Physics (NP) amplitudes in charmless $\Delta S=1$ $B_s$ decays using time-dependent CP asymmetries in these decays and in flavour SU(3) related $\Delta S=0$ decays. For illustration, we assume a hierarchy, $\sim 1: \lambda : \lambda^2$ ($\lambda=0.2$), between a dominant $\Delta S=1$ penguin amplitude, a NP amplitude and a Standard Model amplitude with weak phase $\gamma$. An uncertainty from SU(3) breaking corrections, reduced by using ratios of hadronic amplitudes, is further suppressed by a factor $\lambda$. We discuss examples for pairs of decays into two neutral vector mesons, $B_s\to\phi\phi, B_s\to\phi \bar K^{*0}$ and $B_s\to K^{*0}\bar K^{*0}, B^0\to K^{*0}\bar K^{*0}$, where the magnitude of the NP amplitude, its weak and strong phases can be determined.Comment: typo corrected, reference added, submitted to Physics Letters

Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence.

BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions. Indirect evidence suggests that low dopamine D2-type receptor availability in the striatum contributes to the propensity of these individuals to sacrifice long-term goals for short-term gain; however, this possibility has not been tested directly. We investigated whether striatal D2/D3 receptor availability is negatively correlated with the preference for smaller, more immediate rewards over larger, delayed alternatives among research participants who met DSM-IV criteria for methamphetamine (MA) dependence.MethodsFifty-four adults (n = 27 each: MA-dependent, non-user controls) completed the Kirby Monetary Choice Questionnaire, and underwent positron emission tomography scanning with [(18)F]fallypride.ResultsMA users displayed steeper temporal discounting (p = 0.030) and lower striatal D2/D3 receptor availability (p < 0.0005) than controls. Discount rate was negatively correlated with striatal D2/D3 receptor availability, with the relationship reaching statistical significance in the combined sample (r = -0.291, p = 0.016) and among MA users alone (r = -0.342, p = 0.041), but not among controls alone (r = -0.179, p = 0.185); the slopes did not differ significantly between MA users and controls (p = 0.5).ConclusionsThese results provide the first direct evidence of a link between deficient D2/D3 receptor availability and steep temporal discounting. This finding fits with reports that low striatal D2/D3 receptor availability is associated with a higher risk of relapse among stimulant users, and may help to explain why some individuals choose to continue using drugs despite knowledge of their eventual negative consequences. Future research directions and therapeutic implications are discussed

Academic Primer Series: Five Key Papers for Consulting Clinician Educators.

INTRODUCTION: Clinician educators are often asked to perform consultations for colleagues. Invitations to consult and advise others on local problems can help foster great collaborations between centers, and allows for an exchange of ideas between programs. In this article, the authors identify and summarize several key papers to assist emerging clinician educators with the consultation process. METHODS: A consensus-building process was used to generate a list of key papers that describe the importance and significance of educational consulting, informed by social media sources. A three-round voting methodology, akin to a Delphi study, determined the most impactful papers from the larger list. RESULTS: Summaries of the five most highly rated papers on education consultation are presented in this paper. These papers were determined by a mixed group of junior and senior faculty members, who have summarized these papers with respect to their relevance for their peer groups. CONCLUSION: Five key papers on the educational consultation process are presented in this paper. These papers offer background and perspective to help junior faculty gain a grasp of consultation processes

Tonic Inhibition Enhances Fidelity of Sensory Information Transmission in the Cerebellar Cortex

Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which form the input layer of the cerebellar cortex, permit high-resolution patch-clamp recordings in vivo, and are the only neurons in the cerebellar cortex that express the α6δ-containing GABA(A) receptors mediating tonic inhibition. We investigated how tonic inhibition regulates sensory information transmission in the rat cerebellum by using a combination of intracellular recordings from granule cells and molecular layer interneurons in vivo, selective pharmacology, and in vitro dynamic clamp experiments. We show that blocking tonic inhibition significantly increases the spontaneous firing rate of granule cells while only moderately increasing sensory-evoked spike output. In contrast, enhancing tonic inhibition reduces the spike probability in response to sensory stimulation with minimal effect on the spontaneous spike rate. Both manipulations result in a reduction in the signal-to-noise ratio of sensory transmission in granule cells and of parallel fiber synaptic input to downstream molecular layer interneurons. These results suggest that under basal conditions the level of tonic inhibition in vivo enhances the fidelity of sensory information transmission through the input layer of the cerebellar cortex