Sustainable Professional Practice

The project aims were to examine the ways in which the two distance learning social work programmes (The Open University (OU)and Charles Sturt University(CSU)) operate - looking at pedagogies and in particular how learning and teaching works in the practicum. Exchange visits were organised with Associate Professor Bowles spending 10 days at The Open University in June 2009, and Mick McCormick pending time at CSU in August/September 2009. Our aim was to investigate the different and similar ways in which we approached the teaching of practitioners in social work. We gained many benefits from our contacts and had opportunity to meet and work with social work academics and input to teaching and learning within respective academic institutions. Many of our findings are reflected in recently published work, or work in publication. Findings also have an ongoing impact on the production, delivery and review of our respective practice learning social work programmes

Prepared for Practice? Exploring and Evaluating the First Six Months of Post-qualified Practice in Social Work

This project explores how effective the Social work degree has been in enabling graduates to feel prepared for the practice of social work. Quantitative and qualitative data from online questionnaires and interviews with twelve graduates revealed that graduates perceived they were more confident, despite coming from a background where they were already practicing. They identified ways that this confidence (including in ICT and IL skills) has contributed to their preparedness for practice and their willingness to shape and challenge practices. Areas of practice where graduates felt least prepared included working with hostile service users. In terms of ICT skills development, variations in systems and technologyrelated practices resulted in tensions between the degree providing supportive guidance which fit particular software or social work settings compared with less supportive generic guidance which might be more widely applicable. IL skills were perceived to have more generic applicability

Comparing and Connecting: Comacchio and the Early Medieval Trading Towns

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History's Changing Climate: Climate Science, Genomics, and the Emerging Consilient Approach to Interdisciplinary History

Consilience refers to the quality of investigations that draw conclusions from forms of evidence that are epistemologically distinct. The term seems particularly apt for conclusions produced by natural-scientific investigations on the one hand and by historical and archaeological studies on the other. Consilience points to areas of underlying unity of humanistic and scientific investigation— a unity arising from that of reality itself; it represents a convergence in parallel but independent investigations that results in deductions that are much more robust than any investigation would be able to produce on its own.Histor

U.S. Biodiesel Development: New Markets for Conventional and Genetically Modified Agricultural Products

With environmental and energy source concerns on the rise, using agricultural fats and oils as fuel in diesel engines has captured increasing attention. Substituting petroleum diesel with biodiesel may reduce air emissions, increase the domestic supply of fuel, and create new markets for farmers. U.S. agricultural fats and oils could support a large amount of biodiesel, but high production costs and competing uses for biodiesel feedstocks will likely prevent mass adoption of biodiesel fuel. Higher-priced niche markets could develop for biodiesels as a result of environmental regulations. Biodiesel has many environmental advantages relative to petroleum diesel, such as lower CO, CO2, SOx, and particulate matter emissions. Enhancing fuel properties by genetically modifiying oil crops could improve NOx emissions, cold flow, and oxidative stability, which have been identified as potential problems for biodiesel. Research activities need to be directed toward cost reduction, improving fuel properties, and analyzing the economic effects of biodiesel development on U.S. agriculture.biodiesel, biodiesel blends, fatty acid esters, soybean, oil crops, animal fats, plant genetics, diesel engines, alternative fuels, Resource /Energy Economics and Policy,

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands

We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading frames potentially encoding proteins of more than 50 amino acids, including an apparently functional integrase. The element is bordered by two 17-bp direct repeats identical to those found flanking staphylococcal pathogenicity island 1. The island has extensive regions of homology to previously described pathogenicity islands, particularly staphylococcal pathogenicity islands 1 and bov. The expression of 22 of the 24 open reading frames contained on staphylococcal pathogenicity island 3 was detected either in vitro during growth in a laboratory medium or serum or in vivo in a rabbit model of toxic shock syndrome using DNA microarrays. The effect of oxygen tension on staphylococcal pathogenicity island 3 gene expression was also examined. By comparison with the known staphylococcal pathogenicity islands in the context of gene expression described here, we propose a model of pathogenicity island origin and evolution involving specialized transduction events and addition, deletion, or recombination of pathogenicity island "modules.

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells. The persister cell pool constitutes a reservoir from which drug-resistant tumours may emerge. Targeting persister cells therefore presents a therapeutic opportunity to impede tumour relapse. We previously found that cancer cells in a high mesenchymal therapy-resistant cell state are dependent on the lipid hydroperoxidase GPX4 for survival. Here we show that a similar therapy-resistant cell state underlies the behaviour of persister cells derived from a wide range of cancers and drug treatments. Consequently, we demonstrate that persister cells acquire a dependency on GPX4. Loss of GPX4 function results in selective persister cell ferroptotic death in vitro and prevents tumour relapse in mice. These findings suggest that targeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance

Lunar Atmosphere and Dust Environment Explorer Integration and Test

Integration and test (I&T) of the Lunar Atmosphere and Dust Environment Explorer (LADEE) is presented. A collaborative NASA project between Goddard Space Flight Center and Ames Research Center, LADEE's mission is to explore the low lunar orbit environment and exosphere for constituents. Its instruments include two spectrometers, a dust detector, and a laser communication technology demonstration. Although a relatively low-cost spacecraft, LADEE has I&T requirements typical of most planetary probes, such as prelaunch contamination control, sterilization, and instrument calibration. To lead to a successful mission, I&T at the spacecraft, instrument, and observatory level must include step-by-step and end-to-end functional, environmental, and performance testing. Due to its compressed development schedule, LADEE I&T planning requires adjusting test flows and sequences to account for long-lead critical-path items and limited spares. A protoflight test-level strategy is also baselined. However, the program benefits from having two independent but collaborative teams of engineers, managers, and technicians that have a wealth of flight project experience. This paper summarizes the LADEE I&T planning, flow, facilities, and probe-unique processes. Coordination of requirements and approaches to I&T when multiple organizations are involved is discussed. Also presented are cost-effective approaches to I&T that are transferable to most any spaceflight project I&T program

The SQUAD : Santa Clara Quadrotor Autonomous Drone

We have constructed a quadrotor unmanned aerial vehicle (UAV) that could be used to supplement emergency response personnel, including police and military, when in the field. The SQUAD focused primarily on designing and constructing a sound structure for the UAV, as well as beginning controls work, which will be continued by another team at a later date. This quadrotor UAV has a video camera to provide a live video from its point of view to the user. It carries a global positioning system (GPS) to provide information on its location, and to navigate to waypoints in the immediate area. The quadrotor will be enhanced with pre-loaded commands to take off, land, circle a point, and to hold position. An onboard computer runs the pre-loaded commands and the auto-stabilization system using the GUI programming tool LabVIEW®

Human Apolipoprotein B Transgenic Mice Generated with 207- and 145-Kilobase Pair Bacterial Artificial Chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine

We reported previously that ~80-kilobase pair (kb) P1 bacteriophage clones spanning either the human or mouse apoB gene (clones p158 and p649, respectively) confer apoB expression in the liver of transgenic mice, but not in the intestine. We hypothesized that the absence of intestinal expression was due to the fact that these clones lacked a distant DNA element controlling intestinal expression. To test this possibility, transgenic mice were generated with 145- and 207-kb bacterial artificial chromosomes (BACs) that contained the human apoB gene and more extensive 5'- and 3'-flanking sequences. RNase protection, in situ hybridization, immunohistochemical, and genetic complementation studies revealed that the BAC transgenic mice manifested appropriate apoB gene expression in both the intestine and the liver, indicating that both BACs contained the distant intestinal element. To determine whether the regulatory element was located 5' or 3' to the apoB gene, transgenic mice were generated by co-microinjecting embryos with p158 and either the 5'- or 3'-sequences from the 145-kb BAC. Analysis of these mice indicated that the apoB gene's intestinal element is located 5' to the structural gene. Cumulatively, the transgenic mouse studies suggest that the intestinal element is located between -33 and -70 kb 5' to the apoB gene