An airfoil for general aviation applications

A new airfoil, the NLF(1)-0115, has been recently designed at the NASA Langley Research Center for use in general-aviation applications. During the development of this airfoil, special emphasis was placed on experiences and observations gleaned from other successful general-aviation airfoils. For example, the flight lift-coefficient range is the same as that of the turbulent-flow NACA 23015 airfoil. Also, although beneficial for reducing drag and having large amounts of lift, the NLF(1)-0115 avoids the use of aft loading which can lead to large stick forces if utilized on portions of the wing having ailerons. Furthermore, not using aft loading eliminates the concern that the high pitching-moment coefficient generated by such airfoils can result in large trim drags if cruise flaps are not employed. The NASA NLF(1)-0115 has a thickness of 15 percent. It is designed primarily for general-aviation aircraft with wing loadings of 718 to 958 N/sq m (15 to 20 lb/sq ft). Low profile drag as a result of laminar flow is obtained over the range from c sub l = 0.1 and R = 9x10(exp 6) (the cruise condition) to c sub l = 0.6 and R = 4 x 10(exp 6) (the climb condition). While this airfoil can be used with flaps, it is designed to achieve c(sub l, max) = 1.5 at R = 2.6 x 10(exp 6) without flaps. The zero-lift pitching moment is held at c sub m sub o = 0.055. The hinge moment for a .20c aileron is fixed at a value equal to that of the NACA 63 sub 2-215 airfoil, c sub h = 0.00216. The loss in c (sub l, max) due to leading edge roughness, rain, or insects at R = 2.6 x 10 (exp 6) is 11 percent as compared with 14 percent for the NACA 23015

Heat transfer coefficient saturation in superconducting Nb tunnel junctions contacted to a NbTiN circuit and an Au energy relaxation layer

In this paper we present the experimental realization of a Nb tunnel junction connected to a high-gap superconducting NbTiN embedding circuit. We investigate relaxation of nonequilibrium quasiparticles in a small volume Au layer between the Nb tunnel junction and the NbTiN circuit. We find a saturation in the effective heat-transfer coefficient consistent with a simple theoretical model. This saturation is determined by the thickness of the Au layer. Our findings are important for the design of the ideal Au energy relaxation layer for practical SIS heterodyne mixers and we suggest two geometries, one, using a circular Au layer and, two, using a half-circular Au layer. Our work is concluded with an outlook of our future experiments.Comment: Applied Superconductivity Conference 201

Transportation Barriers to Healthcare in Adults 65+ in the Greater Burlington Area

Introduction. Missed appointments often lead to poorer health care outcomes for patients and pose a major economic burden on medical centers. Transportation is an obstacle to accessing medical care for elderly patients in Vermont and results in delayed medical appointments. Methods. We surveyed senior citizens in Chittenden county to determine both the type of transportation barriers and medical care missed due to the lack of transpor- tation. An original survey assessing the impact of transportation to health care was distributed in person and through an online platform. Participants were asked to identify the following in the past year: how often transportation was an issue for healthcare, specific barriers to transportation, and which specific health care appointments were missed due to lack of transportation. Ninety-six surveys out of a total of 251 collected were included in the analysis. Respondents were grouped into either having high transportation barriers, n=43, (always, often, sometimes had issues in the past year), or low transportation barriers, n=53, (rarely had issues). Results. The high barriers group reported more missed appointments, with eye appointments being the most frequent, and depended more on other modes of trans- portation. The low barriers group was able to drive themselves to their appointments more often. Conclusion. The results suggest a trend between barriers to transportation and a lack of access to healthcare appointments. Although more than half of the survey respondents indicated that they do not currently experience transportation barriers, many expressed concern about the transportation difficulties they could encounter in the future.https://scholarworks.uvm.edu/comphp_gallery/1263/thumbnail.jp

Differential neuroproteomic and systems biology analysis of spinal cord injury

Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it is quite easy to diagnose traumatic SCI, the assessment of injury severity and projection of disease progression or recovery are often challenging, as no consensus biomarkers have been clearly identified. Here rats were subjected to experimental moderate or severe thoracic SCI. At 24h and 7d postinjury, spinal cord segment caudal to injury center versus sham samples was harvested and subjected to differential proteomic analysis. Cationic/anionic-exchange chromatography, followed by 1D polyacrylamide gel electrophoresis, was used to reduce protein complexity. A reverse phase liquid chromatography-tandem mass spectrometry proteomic platform was then utilized to identify proteome changes associated with SCI. Twenty-two and 22 proteins were up-regulated at 24 h and 7 day after SCI, respectively; whereas 19 and 16 proteins are down-regulated at 24 h and 7 day after SCI, respectively, when compared with sham control. A subset of 12 proteins were identified as candidate SCI biomarkers - TF (Transferrin), FASN (Fatty acid synthase), NME1 (Nucleoside diphosphate kinase 1), STMN1 (Stathmin 1), EEF2 (Eukaryotic translation elongation factor 2), CTSD (Cathepsin D), ANXA1 (Annexin A1), ANXA2 (Annexin A2), PGM1 (Phosphoglucomutase 1), PEA15 (Phosphoprotein enriched in astrocytes 15), GOT2 (Glutamic-oxaloacetic transaminase 2), and TPI-1 (Triosephosphate isomerase 1), data are available via ProteomeXchange with identifier PXD003473. In addition, Transferrin, Cathepsin D, and TPI-1 and PEA15 were further verified in rat spinal cord tissue and/or CSF samples after SCI and in human CSF samples from moderate/severe SCI patients. Lastly, a systems biology approach was utilized to determine the critical biochemical pathways and interactome in the pathogenesis of SCI. Thus, SCI candidate biomarkers identified can be used to correlate with disease progression or to identify potential SCI therapeutic targets

Analysis of Accelerometer Data from a Woven Inflatable Creep Burst Test

Accelerometers were used to montor an inflatable test article during a creep test to failure. The test article experienced impulse events that were classified based on the response of the sensors and their time-dependent manifestation. These impulse events required specialized techniques to process the structural dynamics data. However, certain phenomena were defined as worthy of additional study. An assessment of one phenomena (a frequency near 1000Hz) showed a time dependent frequency and an amplitude that increased significantly near the end of the test. Hence, these observations are expected to drive future understanding of and utility in inflatable space structures

Development and Implementation Strategies for International ERP Software Projects

In this paper we address a question highly relevant for many companies developing and implementing ERP or other software internationally. These companies have to integrate subsidiaries all over the world by using standard business processes implemented within the software, while at the same time take care of country-specific and other local requirements. The paper presents a framework of three different strategies, evaluates these strategies, and reports case study results that allow the comparison of these strategies. It is shown, that these strategies are not only relevant for ERP projects, but also for other software projects, especially global e-commerce projects

Differential response to resistance training in CHF according to ACE genotype

The Angiotensin Converting Enzyme (ACE) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype. We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure (CHF) patients. Methods: The relationship between ACE genotype and the response to 11 weeks of resistance exercise training was determined in 37 CHF patients (New York Heart Association Functional Class=2.3±0.5; left ventricular ejection fraction 28±7%; age 64±12 years; 32:5 male:female) who were randomised to either resistance exercise (n=19) or inactive control group (n=18). Outcome measures included V˙ O2peak, peak power output and muscle strength and endurance. ACE genotype was determined using standard methods. Results: At baseline, patients who were homozygous for the I allele had higher V˙ O2peak (p=0.02) and peak power (p=0.003) compared to patients who were homozygous for the D allele. Patients with the D allele, who were randomised to resistance training, compared to non-exercising controls, had greater peak power increases (ID pb0.001; DD pb0.001) when compared with patients homozygous for the I allele, who did not improve. No significant genotype-dependent changes were observed in V˙ O2peak, muscle strength, muscle endurance or lactate threshold. Conclusion: ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition

Precipitation of Trichoderma reesei commercial cellulase preparations under standard enzymatic hydrolysis conditions for lignocelluloses

Comparative studies between commercial Trichoderma reesei cellulase preparations show that, depending on the preparation and loading, total protein precipitation can be as high as 30 % under standard hydrolysis conditions used for lignocellulosic materials. ATR-IR and SDS-PAGE data verify precipitates are protein-based and contain key cell wall hydrolyzing enzymes. Precipitation increased considerably with incubation temperature; roughly 50–150 % increase from 40 to 50 °C and 800 % greater at 60 °C. All of the reported protein losses translated into significant, and often drastic, losses in activity on related 4-nitrophenyl substrates. In addition, supplementation with the non-ionic surfactant PEG 6,000 decreased precipitation up to 80 % in 24 h precipitation levels. Protein precipitation is potentially substantial during enzymatic hydrolysis of lignocelluloses and should be accounted for during lignocellulose conversion process design, particularly when enzyme recycling is considered.This work was supported by the project "Demonstrating Industrial scale second generation bioethaol production-Kalundborg Cellulosic Ethanol Plant" under the EU FP7 framework program and the project "Development of improved second generation (2G) bioethanol technology to prepare for commercialization under the Danish Energy Technology and Demonstration Programme (EUDP)

The Effects of the Critical Ice Accretion on Airfoil and Wing Performance

In support of the NASA Lewis Modern Airfoils Ice Accretion Test Program, the University of Illinois at Urbana-Champaign provided expertise in airfoil design and aerodynamic analysis to determine the aerodynamic effect of ice accretion on modern airfoil sections. The effort has concentrated on establishing a design/testing methodology for "hybrid airfoils" or "sub-scale airfoils," that is, airfoils having a full-scale leading edge together with a specially designed and foreshortened aft section. The basic approach of using a full-scale leading edge with a foreshortened aft section was considered to a limited extent over 40 years ago. However, it was believed that the range of application of the method had not been fully exploited. Thus a systematic study was being undertaken to investigate and explore the range of application of the method so as to determine its overall potential