Dynamical Properties of Heavy-Ion Collisions from the Photon-Photon Intensity Correlations

We consider here the bremsstrahlung emission of photons at low and intermediate energies $E_{lab}\le 1000 MeV/u$ of the projectile. and derive expressions more general than previous results obtained by Neuhauser which were limited to the case of isotropic systems. We find that the two-photon correlation function strongly depends not only on the space-time properties of the collision region but also on the dynamics of the proton-neutron scattering process in nuclear matter. As a consequence of polarisation correlations it turns out that for a purely chaotic source the intercept of the correlation function of photons can reach the value $3$ (as compared with the maximum value $2$ for isotropic systems). Furthermore even for ``hard" photons ($E_{\gamma} > 25 MeV$) the maximum of the correlation function can reach the value of $2$ in contrast with the value of $1.5$ derived by Neuhauser for this case. The formulae obtained in this paper which include also the possible presence of a coherent component can be used as a basis for a systematic analysis of photon intensity-interferometry experiments.Comment: 12 pages, LaTeX, DMR-THEP-93-2/

Intermolecular interaction and solid state characterization of abietic acid/chitosan solid dispersions possessing antimicrobial and antioxidant properties

The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the biomedical field or the food industry. Solid dispersions were characterized by differential scanning calorimetry, infrared spectroscopy, Raman spectroscopy, polarized optical microscopy, zeta potential and size analysis. The data showed that the dispersion/solvent evaporation method formed solid dispersions in which abietic acid was molecularly dispersed in the carrier. A synergistic effect between the two components in terms of antioxidant and antimicrobial properties was found, especially in the formulations obtained with 1/1 AB/CS molar ratio. Interestingly, the aggregation state (amorphous/crystalline) of AB seemed to affect the antimicrobial activity of the formulation, suggesting increased bioactivity when the drug was in the amorphous state. These findings, together with the demonstrated biocompatibility of the formulations, seem to open promising perspectives for a successful application of the developed AB/CS formulations in the biomedical field or in the food industry

Novel locally active estrogens accelerate cutaneous wound healing-part 2

Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds. However, current estrogenic molecules have undesired systemic effects, thus the aim of our studies is to generate new molecules for topic administration that are devoid of systemic effects. Following a preliminary study, the new 17β-estradiol derivatives 1 were synthesized. The estrogenic activity of these novel compounds was evaluated in vitro using the cell line ERE-Luc B17 stably transfected with an ERE-Luc reporter. Among the 17β-estradiol derivatives synthesized, compounds 1e and 1f showed the highest transactivation potency and were therefore selected for the study of their systemic estrogenic activity. The study of these compounds in the ERE-Luc mouse model demonstrated that both compounds lack systemic effects when administered in the wound area. Furthermore, wound-healing experiments showed that 1e displays a significant regenerative and anti-inflammatory activity. It is therefore confirmed that this class of compounds are suitable for topical administration and have a clear beneficial effect on wound healing

Simulation of large photomultipliers for experiments in astroparticle physics

We have developed an accurate simulation model of the large 9 inch photomultiplier tubes (PMT) used in water-Cherenkov detectors of cosmic-ray induced extensive air-showers. This work was carried out as part of the development of the Offline simulation software for the Pierre Auger Observatory surface array, but our findings may be relevant also for other astrophysics experiments that employ similar large PMTs. The implementation is realistic in terms of geometrical dimensions, optical processes at various surfaces, thin-film treatment of the photocathode, and photon reflections on the inner structure of the PMT. With the quantum efficiency obtained for this advanced model we have calibrated a much simpler and a more rudimentary model of the PMT which is more practical for massive simulation productions. We show that the quantum efficiency declared by manufactures of the PMTs is usually determined under conditions substantially different from those relevant for the particular experiment and thus requires careful (re)interpretation when applied to the experimental data or when used in simulations. In principle, the effective quantum efficiency could vary depending on the optical characteristics of individual events.Comment: 8 pages, 11 figure

Atmospheric MUons from PArametric formulas: a fast GEnerator for neutrino telescopes (MUPAGE)

Neutrino telescopes will open, in the next years, new opportunities in observational high energy astrophysics. For these experiments, atmospheric muons from primary cosmic ray interactions in the atmosphere play an important role, because they provide the most abundant source of events for calibration and test. On the other side, they represent the major background source. In this paper a fast Monte Carlo generator (called MUPAGE) of bundles of atmospheric muons for underwater/ice neutrino telescopes is presented. MUPAGE is based on parametric formulas [APP25(2006)1] obtained from a full Monte Carlo simulation of cosmic ray showers generating muons in bundle, which are propagated down to 5 km w.e. It produces the event kinematics on the surface of a user-defined virtual cylinder, surrounding the detector. The multiplicity of the muons in the bundle, the muon spatial distribution and energy spectrum are simulated according to a specific model of primary cosmic ray flux, with constraints from measurements of the muon flux with underground experiments. As an example of the application, the result of the generation of events on a cylindrical surface of 3 km^2 at a depth of 2450 m of water is presented.Comment: 20 pages, 4 figure

Strong enhancement of extremely energetic proton production in central heavy ion collisions at intermediate energy

The energetic proton emission has been investigated as a function of the reaction centrality for the system 58Ni + 58Ni at 30A MeV. Extremely energetic protons (EpNN > 130 MeV) were measured and their multiplicity is found to increase almost quadratically with the number of participant nucleons thus indicating the onset of a mechanism beyond one and two-body dynamics.Comment: 5 pages, 2 figures, submitted to Physical Review Letter

Contemporary presence of dynamical and statistical production of intermediate mass fragments in midperipheral 58^{58}Ni+58^{58}Ni collisions at 30 MeV/nucleon

The $^{58}Ni+^{58}Ni$ reaction at 30 MeV/nucleon has been experimentally investigated at the Superconducting Cyclotron of the INFN Laboratori Nazionali del Sud. In midperipheral collisions the production of massive fragments (4$\le$Z$\le$12), consistent with the statistical fragmentation of the projectile-like residue and the dynamical formation of a neck, joining projectile-like and target-like residues, has been observed. The fragments coming from these different processes differ both in charge distribution and isotopic composition. In particular it is shown that these mechanisms leading to fragment production act contemporarily inside the same event.Comment: 9 pages, minor correction