Towards energy resolution at the statistical limit from a negative ion time projection chamber

We make a proof-of-principle demonstration that improved energy resolution can be obtained in a negative-ion time projection chamber, by individually counting each electron produced by ionizing radiation.Comment: Submitted to Nucl. Instr. Meth.

Measurement of high-p_T Single Electrons from Heavy-Flavor Decays in p+p Collisions at sqrt(s) = 200 GeV

The momentum distribution of electrons from decays of heavy flavor (charm and beauty) for midrapidity |y| < 0.35 in p+p collisions at sqrt(s) = 200 GeV has been measured by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC) over the transverse momentum range 0.3 < p_T < 9 GeV/c. Two independent methods have been used to determine the heavy flavor yields, and the results are in good agreement with each other. A fixed-order-plus-next-to-leading-log pQCD calculation agrees with the data within the theoretical and experimental uncertainties, with the data/theory ratio of 1.72 +/- 0.02^stat +/- 0.19^sys for 0.3 < p_T < 9 GeV/c. The total charm production cross section at this energy has also been deduced to be sigma_(c c^bar) = 567 +/- 57^stat +/- 224^sys micro barns.Comment: 375 authors from 57 institutions, 6 pages, 3 figures. Submitted to Physical Review Letters. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

The Adaptive Code Kitchen: Flexible Tools for Dynamic Application Composition

Driven by the increasing componentization of scientific codes, the deployment of high-end system infrastructures such as the Grid, and the desire to support high level problem solving primitives, application composition systems have become prevalent in computational science practice. We present the adaptive code kitchen which, as the name connotes, is a loose collection of capabilities to help realize complex adaptive composition scenarios. These include function interception, continuation modification, dynamic process checkpointing and rollback, and runtime recommendation. Using these broad primitives, a computational scientist can specify many ‘recipes ’ of adaptivity as complete control systems around native object codes. Runtime systems support then enables loading and linking of native code components, monitoring of performance indicators, consulting a recommender system for algorithmic decisions, and dynamically updating application components in response to the recommendations. We present the architecture of the adaptive code kitchen and the key enabling technologies with brief mention of the applications that will be investigated henceforth during the course of the project. 1

CHO microRNA engineering is growing up: Recent successes and future challenges

AbstractmicroRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of Chinese Hamster Ovary cells. However, until recently, research was limited by a lack of genomic sequence information on this industrially important cell line. With the publication of the genomic sequence and other relevant data sets for CHO cells since 2011, the doors have been opened for an improved understanding of CHO cell physiology and for the development of the necessary tools for novel engineering strategies. In the present review we discuss both knowledge on the regulatory mechanisms of microRNAs obtained from other biological models and proof of concepts already performed on CHO cells, thus providing an outlook of potential applications of microRNA engineering in production cell lines

"Risky Business":Constructing the 'choice' to 'delay' motherhood in the British press

Over the last few decades the number of women becoming pregnant later on in life has markedly increased. Medical experts have raised concerns about the increase in the number of women having babies later, owing to evidence that suggests that advancing maternal age is associated with both a decline in fertility and an increase in health risks to both mother and baby. In recognition of these risks, experts have warned that women should aim to have their children between the ages of twenty and thirty-five. As a consequence, women giving birth past the age of thirty-five have typically been positioned as “older mothers.” In this paper we used a social constructionist thematic analysis in order to analyse how “older mothers” are represented in newspaper articles in the British press. We examined how the topics of “choice” and “risk” are handled in discussions of delayed motherhood, and found that the media position women as wholly responsible for choosing the timing of pregnancy and, as a consequence, as accountable for the associated risks. Moreover, we noted that newspapers also constructed a “right” time for women to become pregnant. As such, we discuss the implications for the ability of women to make real choices surrounding the timing of pregnancy