Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model.

Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the unlasered portions of trabecular meshwork (TM) of laser-treated primate eyes are understudied. We studied NHPs with ExGl of several years duration. As expected, ExGl eyes exhibited selective reductions of the retinal nerve fiber layer that correlate with electrophysiologic measures documenting a link between morphologic and elctrophysiologic endpoints. Softening of unlasered TM in ExGl eyes compared to untreated controls was observed. The degree of TM softening was consistent, regardless of pre-mortem clinical findings including severity of IOP elevation, retinal nerve fiber layer thinning, or electrodiagnostic findings. Importantly, this softening is contrary to TM stiffening reported in glaucomatous human eyes. Furthermore, microscopic analysis of unlasered TM from eyes with ExGl demonstrated TM thinning with collapse of Schlemm's canal; and proteomic analysis confirmed downregulation of metabolic and structural proteins. These data demonstrate unexpected and compensatory changes involving the TM in the NHP model of ExGl. The data suggest that compensatory mechanisms exist in normal animals and respond to elevated IOP through softening of the meshwork to increase outflow

Junior Recital: Charlie Miller, Clarinet; Momoko Gresham, Piano; November 3, 2023

Kemp Recital HallNovember 3, 2023Friday Evening6:00 p.m

Prospectus, January 13, 1975

IT\u27S OFFICIAL , CALL FOR BOYCOTT!; Reorganized Group Calls For Activism; ISSC Re-opens Award Giveaway; Cite 5 Grievances Against Canteen Food Service; Great Thoughts From LRC Suggestion Box; Uncle John\u27s in For Competition; 79% Want Government To Limit Big Business; PC Agriculture Department Moves Out To Learning Centers; Table Tennis M...; File Petition For Graduation; American Zoos In Danger Of Becoming Extinct; Mighty Joe Young To Perform Thursday; Bouncy, Bluesy Hound Dog Taylor; Eighth Anniversary Of Apollo Astronauts Death; support boycott; Mulhouse & Outhouse; True Happenings; students for action; sour grapes; Female Focus; letters; Joint Venture; Classified Ads; Art Works By Phyllis Ward Now On Display; Pritchett Primes Club For Outing Vs. Illni JV; Oliver Leads Cobra Cagers Past Kaskaskia; Intramural Basketball; Parkland Events; Callboard; Contract Bridge Championship Open To PC Contestantshttps://spark.parkland.edu/prospectus_1975/1019/thumbnail.jp

Prospectus, February 3, 1975

PC SPEECH, DEBATE RAP OPPONENTS; Forensics Squad Third In 27 Team Field; Debate Team Takes 1st In DuPage Tourney; Young Republicans To Try Again; Japanese Flower Arrangers Meeting; StuGo Ends Boycott Against Canteen; UFO Expert Speaks Today; Parkland-MTD Conference; WIU Offers BIO Scholarship; Get Your Own Inner Peace; Financial Aid; Quarter To Semester System Switch Coming; editorials; The Kaleidoscope; The Short Circuit; essay: Boycott Canteen?; True Happenings; letters; Classified Ads; Cobras Continue On Rampage; Lake Land Losses; Becky Beach Leads Women Cagers; Bouncing Bob\u27s Basketball Bonanza; Intramural Basketball; \u27Oswald Acted Alone\u27?; Parkland Events; Convocations To Show Marlon Brando Flicks; Deodato, Christopoulos To Play At ISU Wed.; Callboardhttps://spark.parkland.edu/prospectus_1975/1016/thumbnail.jp

The Failure of Environmental Education (and How We Can Fix It)

The authors argue that environmental education curricula have failed to create an ecologically literate and environmentally sensitive populace, and suggest seven ways that an "evidence-based" approach can help

Understanding Deer, Bear, and Forest Trends in the North Georgia Mountains: The Value of Long-term Data

Most state wildlife agencies collect harvest data to inform management decisions. However, these data are typically considered across relatively short time periods and are rarely revisited. We present a case study using historical records to investigate potential agents (i.e., harvest, predation, and forest change) influencing the declining white-tailed deer (Odocoileus virginianus) population in the north Georgia mountains. We used long-term black bear (Ursus americanus) and deer harvest data, and indices of forest stand conditions from 1979–2015 on eight Wildlife Management Areas (WMAs) in the north Georgia mountains. During 1979–2015, harvest of male and female deer declined by 85% and 97%, respectively. Over the same time period, mean yearling male deer body weight increased by 21%, mean antler diameter increased by 62%, and mean antler beam length increased by 92%. We observed a 97% reduction in availability of early successional forests (0–10 years old) and a 53% increase in volume of large diameter (\u3e27.9 cm) oak species, suggesting increasing homogeneity/maturation of forest stands across all eight WMAs. Concomitantly, the U.S. Forest Service increased the acreage under prescribed fire management from 2,916 to 5,629 ha during 2003–2015. Black bear populations grew at an annual rate of 1.07 for males and 1.08 for females. Our analyses indicated that despite the reduction in early successional habitats as illustrated by the reduction in young forests (0–10 years old), deer condition indices have improved suggesting that a habitat-driven change in fecundity was not the likely primary driver of the deer population decline. However, increasing fawn predation, coupled with a decline in available fawning cover may be reducing recruitment rates and should be investigated as potential causes for the observed population decline. Our research also illustrates the importance of maintaining longterm data, especially the value offered to evaluate trends over time