Roses and Bones

Fiction by Camille Millie

Spider Swing

Poem by Camille Millie

The Wild Cats of Aoshima Island

Poetry by Camille Millier

Les enjeux de la conférence de Paris : penser autrement la question climatique

International audienc

Corrosion sous contrainte assistée par l'irradiation en milieu primaire d'aciers inoxydables austénitiques

National audienceLes internes de cuves des REP sont soumis à divers modes de sollicitation, notamment de corrosion sous contrainte assistée par l'irradiation (IASCC). L'objectif de ce travail est d'étudier le couplage de plusieurs phénomènes physiques et chimiques interagissant en IASCC. En particulier, nous nous intéresserons au couplage microstructure (hétérogénéités chimique, cristallographique, nature des joints de grains...) / mécanismes de déformation / mécanismes d'irradiation / effet de l'environnement / champs mécaniques. Nous présenterons notamment la méthodologie et les premiers résultats concernant l'irradiation aux protons sur matériau massif et les essais de corrosion sous contrainte associés ; ainsi que la méthodologie concernant l'irradiation de lames minces qui sera effectuée sur la plate-forme JANNUS du CSNSM, où le matériau sera exposé simultanément à un faisceau d'irradiation et un faisceau d'implantation d'hélium

Alien Registration- Millier, Joseph (Sanford, York County)

https://digitalmaine.com/alien_docs/2617/thumbnail.jp

Alien Registration- Millier, Eugenie (Sanford, York County)

https://digitalmaine.com/alien_docs/2616/thumbnail.jp

Modelling the consequences of a reduction in alcohol consumption among patients with alcohol dependence based on real-life observational data.

BACKGROUND: Most available pharmacotherapies for alcohol-dependent patients target abstinence; however, reduced alcohol consumption may be a more realistic goal. Using randomized clinical trial (RCT) data, a previous microsimulation model evaluated the clinical relevance of reduced consumption in terms of avoided alcohol-attributable events. Using real-life observational data, the current analysis aimed to adapt the model and confirm previous findings about the clinical relevance of reduced alcohol consumption. METHODS: Based on the prospective observational CONTROL study, evaluating daily alcohol consumption among alcohol-dependent patients, the model predicted the probability of drinking any alcohol during a given day. Predicted daily alcohol consumption was simulated in a hypothetical sample of 200,000 patients observed over a year. Individual total alcohol consumption (TAC) and number of heavy drinking days (HDD) were derived. Using published risk equations, probabilities of alcohol-attributable adverse health events (e.g., hospitalizations or death) corresponding to simulated consumptions were computed, and aggregated for categories of patients defined by HDDs and TAC (expressed per 100,000 patient-years). Sensitivity analyses tested model robustness. RESULTS: Shifting from >220 HDDs per year to 120-140 HDDs and shifting from 36,000-39,000 g TAC per year (120-130 g/day) to 15,000-18,000 g TAC per year (50-60 g/day) impacted substantially on the incidence of events (14,588 and 6148 events avoided per 100,000 patient-years, respectively). Results were robust to sensitivity analyses. CONCLUSIONS: This study corroborates the previous microsimulation modeling approach and, using real-life data, confirms RCT-based findings that reduced alcohol consumption is a relevant objective for consideration in alcohol dependence management to improve public health