In their own words: Analysing students’ comments from the Postgraduate Taught Experience Survey

This report presents findings from an analysis of free text comments left by students in the PTES 2014. It is the first attempt to look closely at the feedback of PGT students at the sector level to identify the dominant themes within taught postgraduate education. The report focuses on four areas of the survey: student expectations and perceptions of quality of teaching and learning; engagement with their study; the most enjoyable element of their experience; and what needs to be improved

SPH simulations of Shakura-Sunyaev instability at intermediate accretion rates

We show that a standard Shakura-Sunyaev accretion disc around a black hole with an accretion rate lower than the critical Eddington limit does show the instability in the radiation pressure dominated zone. We obtain this result performing time-dependent simulations of accretion disks for a set of values of the viscosity parameter and accretion rate. In particular we always find the occurrence of the collapse of the disc: the instability develops always towards a collapsed gas pressure dominated disc and not towards the expansion. This result is valid for all initial configurations we tested. We find significant convective heat flux that increases the instability development time, but is not strong enough to inhibit the disc collapse. A physical explanation of the lack of the expansion phase is proposed considering the role of the radial heat advection. Our finding is relevant since it excludes the formation of the hot comptonizing corona -often suggested to be present- around the central object by the mechanism of the Shakura-Sunyaev instability. We also show that, in the parameters range we simulated, accretion disks are crossed by significant amplitude acoustic waves.Comment: 8 pages, 12 Postscript figures, uses natbib.sty, accepted for publication in MNRA

Gaining the hard yard: pre-clinical evaluation of lentiviral-mediated gene therapy for the treatment of β-thalassemia

Gene therapy is one potential novel therapeutic avenue for the treatment of inherited monogenic disorders. Diseases of the blood are frequent targets for gene therapy because it is relatively easy to harvest haematopoietic stem cells (HSCs) from the bone marrow, genetically modify the cells ex vivo, and then re-administer the corrected cells back into the patient via intra-venous injection. In this Closeup, Milsom and Williams discuss the work of Roselli et al, who describe the pre-clinical evaluation of the treatment for β-thalassemia in erythroid cells via the genetic correction of patient HSCs using a lentiviral vector

Patient perceptions regarding benefits of single visit scale and polish : a randomised controlled trial

Peer reviewedPublisher PD

Modeling the Formation of Clouds in Brown Dwarf Atmospheres

Because the opacity of clouds in substellar mass object (SMO) atmospheres depends on the composition and distribution of particle sizes within the cloud, a credible cloud model is essential for accurately modeling SMO spectra and colors. We present a one--dimensional model of cloud particle formation and subsequent growth based on a consideration of basic cloud microphysics. We apply this microphysical cloud model to a set of synthetic brown dwarf atmospheres spanning a broad range of surface gravities and effective temperatures (g_surf = 1.78 * 10^3 -- 3 * 10^5 cm/s^2 and T_eff = 600 -- 1600 K) to obtain plausible particle sizes for several abundant species (Fe, Mg2SiO4, and Ca2Al2SiO7). At the base of the clouds, where the particles are largest, the particle sizes thus computed range from ~5 microns to over 300 microns in radius over the full range of atmospheric conditions considered. We show that average particle sizes decrease significantly with increasing brown dwarf surface gravity. We also find that brown dwarfs with higher effective temperatures have characteristically larger cloud particles than those with lower effective temperatures. We therefore conclude that it is unrealistic when modeling SMO spectra to apply a single particle size distribution to the entire class of objects.Comment: 25 pages; 8 figures. We have added considerable detail describing the physics of the cloud model. We have also added discussions of the issues of rainout and the self-consistent coupling of clouds with brown dwarf atmospheric models. We have updated figures 1, 3, and 4 with new vertical axis labels and new particle sizes for forsterite and gehlenite. Accepted to the Astrophysical Journal, Dec. 2, 200

Benefits and Risks of Weight-Loss Treatment for Older, Obese Women

Background: A key issue in the treatment of obesity in older adults is whether the health benefits of weight loss outweigh the potential risks with respect to musculoskeletal injury. Objective: To compare change in weight, improvements in metabolic risk factors, and reported musculoskeletal adverse events in middle-aged (50-59 years) and older (65-74 years), obese women. Materials and methods: Participants completed an initial 6-month lifestyle intervention for weight loss, comprised of weekly group sessions, followed by 12 months of extended care with biweekly contacts. Weight and fasting blood samples were assessed at baseline, month 6, and month 18; data regarding adverse events were collected throughout the duration of the study. Results: Both middle-aged (n = 162) and older (n = 56) women achieved significant weight reductions from baseline to month 6 (10.1 +/- 0.68 kg and 9.3 +/- 0.76 kg, respectively) and maintained a large proportion of their losses at month 18 (7.6 +/- 0.87 kg and 7.6 +/- 1.3 kg, respectively); there were no significant differences between the two groups with respect to weight change. Older women further experienced significant reductions in systolic blood pressure, HbA(1c), and C-reactive protein from baseline to month 6 and maintained these improvements at month 18. Despite potential safety concerns, we found that older women were no more likely to experience musculoskeletal adverse events during the intervention as compared with their middle-aged counterparts. Conclusion: These results suggest that older, obese women can experience significant health benefits from lifestyle treatment for obesity, including weight loss and improvements in disease risk factors. Further investigation of the impact of weight loss on additional health-related parameters and risks (eg, body composition, muscular strength, physical functioning, and injuries) in older adults is needed.National Heart, Lung and Blood Institute R18HL73326University of FloridaDivision of Statistics and Scientific Computatio

Relativistic Diskoseismology

We will summarize results of calculations of the modes of oscillation trapped within the inner region of accretion disks by the strong-field gravitational properties of a black hole (or a compact, weakly-magnetized neutron star). Their driving and damping will also be addressed. The focus will be on the most observable class: the analogue of internal gravity modes in stars. Their frequencies which corrrespond to the lowest mode numbers depend almost entirely upon only the mass and angular momentum of the black hole. Such a feature may have been detected in the X-ray power spectra of two galactic `microquasars', allowing the angular momentum of the black hole to be determined in one case.Comment: To be published in Physics Reports, proceedings of the conference Astrophysical Fluids: From Atomic Nuclei to Stars and Galaxies; 10 pages, 5 postscript figure

Can using Fagan Inspections improve the quality of specification in 2011? A Case Study

In this paper, we explore why Fagan Inspections have become obsolete in the software industry, given the body of evidence which supports their use to improve the quality of software artefacts and the software development process. Since the late 1970’s, much has been written about how Fagan Inspections improve the quality of both processes and outputs of the software development process. The literature indicates that the Fagan Inspection technique can improve quality of software (or other software development artefacts) by a reduction in defects of 60 – 90%. However, recent literature suggests that inspection techniques in general and Fagan Inspections in particular, are no longer used. A study in 1998 found that respondents used inspections either irregularly or not at all. Teams often review artefacts informally, but believe that they are performing an inspection or formal review. The lack of rigour in the review process results in reduced benefits and more defects in the artefacts. To explore this situation, we conducted a case study with a local enterprise and we report on the early findings. These suggest that the introduction of Fagan Inspections may have a number of benefits before they have even been introduced fully, including recognition of flaws in the current development process, development of technical knowledge relating to the software process domain, and improved team relations and a ‘quality’ culture. In addition, the personnel using Fagan Inspection gain experience in the production of ‘quality’ artefacts

Thermal acclimation of surfactant secretion and its regulation by adrenergic and cholinergic agonists in type II cells isolated from warm-active and torpid golden-mantled ground squirrels, Spermophilus lateralis

Homeothermic mammals experience pulmonary surfactant dysfunction with relatively small fluctuations in body temperature. However, ground squirrels survive dramatic changes in body temperature during hibernation, when body temperature drops from 37°C to 0-5°C during prolonged torpor bouts. Using type II cells isolated from both warm-active and torpid squirrels, we determined the effect of assay temperature, autonomic agonists and torpor on surfactant secretion. Basal secretion was significantly higher in type II cells isolated from torpid squirrels compared with warm-active squirrels when assayed at the body temperature of the animal from which they were isolated (4°C and 37°C, respectively). A change in assay temperature significantly decreased surfactant secretion. However, the change in secretory rate between 37°C and 4°C was less than expected if due to temperature alone (Q₁₀ range=0.8-1.2). Therefore, the surfactant secretory pathway in squirrel type II cells demonstrates some temperature insensitivity. When incubated at the body temperature of the animal from which the cells were isolated, the adrenergic agonist, isoproterenol, significantly increased surfactant secretion in both warm-active and torpid squirrel type II cells. However, the cholinergic agonist, carbamylcholine chloride, only increased secretion in torpid squirrel type II cells when incubated at 4°C. Torpor did not affect basal cAMP production from isolated type II cells. However, the production of cAMP appears to be upregulated in response to isoproterenol in torpid squirrel type II cells. Thus, at the cellular level, both the secretory and regulatory pathways involved in surfactant secretion are thermally insensitive. Upregulating basal secretion and increasing the sensitivity of type II cells to cholinergic stimulation may be adaptative characteristics of torpor that enable type II cells to function effectively at 0-5°C.Carol J. Ormond, Sandra Orgeig, Christopher B. Daniels and William K. Milso