"Sudden Drop" in Blood Pressure is Associated With Recanalization After Thrombolysis.

We aim to investigate whether the phenomenon of "sudden drop" in blood pressure (BP) within the first 2 hours is associated with vessel recanalization.We retrospectively examined clinical and imaging data from a consecutive series of patients with stroke with large vessel occlusion treated with intravenous thrombolysis (IVT). BP was monitored every 15 minutes during the first 2 hours, then every 30 minutes for 6 hours, and then every hour for 16 hours.We observed the phenomenon of "sudden drop" in systolic BP (≥20 mm Hg) in 82 (50.9%) patients in the first 2 hours and vessel recanalization in 87 (54.0%) patients 24 hours after treatment. This phenomenon was independently associated with recanalization (odds ratio 2.100; 95% confidence interval: 1.085-4.062; P = 0.028) after adjusting for the history of atrial fibrillation, coronary heart disease, and hypertension.The phenomenon of "sudden drop" in systolic BP with 20 mm Hg or greater between 2 continuous measurements within the first 2 hours is associated with recanalization after IVT in patients with large vessel occlusion, especially for middle cerebral artery occlusion

Mapping and validation of quantitative trait loci associated with concentrations of 16 elements in unmilled rice grain

Acknowledgments This research was supported in part by the US National Science Foundation, Plant Genome Research Program (Grant #IOS 0701119) awarded to D.E.S, M.L.G and S.R.M.P. We acknowledge Dr. Kathleen Yeater for consultation on analyzing marker-trait associations using SAS JMP Genomics. Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the US Department of Agriculture or Texas A&M AgriLife Research, and does not imply its approval to the exclusion of other products that also can be suitable. USDA is an equal opportunity provider and employer.Peer reviewedPublisher PD