Explaining the Size Distribution of Plants: An Approach Based on Civic Capital

We show that the distribution of plant size within narrowly defined industries is affected by the variation in the stock of civic capital that occurs at the provincial level. Data on plant size come from the 2001 Italian Census of Manufacturing and Services. Civic capital turns out to have a positive effect on both the average and the standard deviation of the plant size distribution. This effect is stronger in labor-intensive industries. The potential endogeneity of current civic capital is addressed by instrumenting it with historical variables. Our interpretation for these results is that civic capital is associated with reduced opportunistic behavior, which improves intra-firm cooperation and hampers the incidence of principal-agent problems, thus allowing plants to operate on a larger scale.

Foreign ownership, firm performance, and the geography of civic capital

It is well established in the literature that foreign affiliates are subject to a series of governance and assimilation costs that deteriorate their performance. This is particularly relevant for firms which have been recently acquired by foreign investors. We employ the variation in civic capital across Italian provinces as an exogenous determinant of these governance costs. We derive the testable implication that there should be a clean evidence of a negative effect of foreign ownership on performance in areas where civic capital is low. As the level of local civic capital increases, this reduces the scope for internal transaction costs, and makes the governance of foreign affiliates easier, and their performance better. We take this prediction to the data and find confirmation of our conceptual framework. Our analysis underlines the importance of the geographic heterogeneity of informal institutions when analyzing the effect of foreign ownership on firm performance.

Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia

Objectives: To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes. Design: Prospective observational cohort study. Setting: General population from a semi-rural area. Participants: The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014. Results: The prevalence of undiagnosed diabetes was 20, 3.4% (95% CI 2.6 to 4.2) and that of pre-diabetes was 229, 39.3% (37.3 to 41.3). Among those with pre-diabetes, 18.3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58.1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5.7 to <6.5) and 23.6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41.6%(37.8 to 45.4) returned to normoglycaemia, 57.6% (57.8 to 61.4) persisted in pre-diabetes and 0.6% (0 to 1.2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1.033; 1.011 to 1.056), higher physical activity (0.546; 0.360 to 0.827), body mass index (1.121; 1.029 to 1.222) and a family history of diabetes (1.543; 1.025 to 2.323). The variables significantly associated with glycaemic normalisation were older age (0.948; 0.916 to 0.982) and body mass index (0.779; 0.651 to 0.931). Conclusions: Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3.4% and that of pre-diabetes was 39.3%. After a 1-year follow-up, a small proportion of subjects (0.6%) with pre-diabetes progressed to diabetes, while a high proportion (41.6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass inde

Detecting matter effects in long baseline experiments

Experiments strongly suggest that the flavour mixing responsible for the atmospheric neutrino anomaly is very close to being maximal. Thus, it is of great theoretical as well as experimental importance to measure any possible deviation from maximality. In this context, we reexamine the effects of matter interactions in long baseline neutrino oscillation experiments. Contrary to popular belief, the muon neutrino survival probability is shown to be quite sensitive to matter effects. Moreover, for moderately long baselines, the difference between the survival probilities for $\nu_\mu$ and $\bar\nu_\mu$ is shown to be large and sensitive to the deviation of $|U_{\mu 3}|$ from maximality. Performing a realistic analysis, we demonstrate that a muon-storage ring $\nu$-source alongwith an iron calorimeter detector can measure such deviations. (Contrary to recent claims, this is not so for the NuMI--{\sc minos} experiment.) We also discuss the possible correlation in measuring $U_{\mu 3}$ and $U_{e3}$ in such experiment.Comment: 18 pages, LaTe

Status and perspectives of short baseline studies

The study of flavor changing neutrinos is a very active field of research. I will discuss the status of ongoing and near term experiments investigating neutrino properties at short distances from the source. In the next few years, the Double Chooz, RENO and Daya Bay reactor neutrino experiments will start looking for signatures of a non-zero value of the mixing angle $\theta_{13}$ with much improved sensitivities. The MiniBooNE experiment is investigating the LSND anomaly by looking at both the $\nu_{\mu} \to \nu_{e}$ and $\bar{\nu}_{\mu} \to \bar{\nu}_{e}$ appearance channels. Recent results on cross section measurements will be discussed briefly.Comment: 6 pages, 2 figures, to appear in the proceedings of the 11th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2009), Rome, Italy, 1-5 July 200

Explaining LSND by a decaying sterile neutrino

We propose an explanation of the LSND evidence for electron antineutrino appearance based on neutrino decay. We introduce a heavy neutrino, which is produced in pion and muon decays because of a small mixing with muon neutrinos, and then decays into a scalar particle and a light neutrino, predominantly of the electron type. We require values of $g m_4\sim$ few eV, $g$ being the neutrino--scalar coupling and $m_4$ the heavy neutrino mass, e.g. $m_4$ in the range from 1 keV to 1 MeV and $g \sim 10^{-6} - 10^{-3}$. Performing a fit to the LSND data as well as all relevant null-result experiments, we show that all data can be explained within this decay scenario. In the minimal version of the decay model, we predict a signal in the upcoming MiniBooNE experiment corresponding to a transition probability of the same order as seen in LSND. In addition, we show that extending our model to two nearly degenerate heavy neutrinos it is possible to introduce CP violation in the decay, which can lead to a suppression of the signal in MiniBooNE running in the neutrino mode. We briefly discuss signals in future neutrino oscillation experiments, we show that our scenario is compatible with bounds from laboratory experiments, and we comment on implications in astrophysics and cosmology.Comment: 23 pages, 5 figures, minor improvements, matches published versio

Alien Registration- Thompson, Minerva M. (Fryeburg, Oxford County)

https://digitalmaine.com/alien_docs/18080/thumbnail.jp

Measurement of Muon Antineutrino Quasi-Elastic Scattering on a Hydrocarbon Target at E_{\nu} ~ 3.5 GeV

We have isolated muon anti-neutrino charged-current quasi-elastic interactions occurring in the segmented scintillator tracking region of the MINERvA detector running in the NuMI neutrino beam at Fermilab. We measure the flux-averaged differential cross-section, d{\sigma}/dQ^2, and compare to several theoretical models of quasi-elastic scattering. Good agreement is obtained with a model where the nucleon axial mass, M_A, is set to 0.99 GeV/c^2 but the nucleon vector form factors are modified to account for the observed enhancement, relative to the free nucleon case, of the cross-section for the exchange of transversely polarized photons in electron-nucleus scattering. Our data at higher Q^2 favor this interpretation over an alternative in which the axial mass is increased.Comment: 8 pages, 5 figures. Added correlation between neutrino and anti-neutrino results in ancillary text files (CSV

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, ratelimiting step. Genetic loss of PHGDH is toxic towards PHGDH-overexpressing breast cancer cell lines even in the presence of exogenous serine. Here, we use a quantitative high-throughput screen to identify small molecule PHGDH inhibitors. These compounds reduce the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors. Surprisingly, PHGDH inhibition reduced the incorporation into nucleotides of one-carbon units from glucose-derived and exogenous serine. We conclude that glycolytic serine synthesis coordinates the use of one-carbon units from endogenous and exogenous serine in nucleotide synthesis, and suggest that one-carbon unit wasting may contribute to the efficacy of PHGDH inhibitors in vitro and in vivo.Damon Runyon Cancer Research Foundation (Sally Gordon Fellowship DRG-112-12)United States. Dept. of Defense. Breast Cancer Research Program (Postdoctoral Fellowship BC120208)American Society for Radiation Oncology (Resident Seed Grant RA-2011-1)European Molecular Biology Organization (Long-Term Fellowship)National Institutes of Health (U.S.) (R03 DA034602-01A1, R01 CA129105, R01 CA103866, and R37 AI047389)United States. Department of Defense (W81XWH-14-PRCRP-IA)Alexander and Margaret Stewart Trus