Regional social infrastructure management in the system of tools used for improving the quality of life for regional population

This paper analyzes the processes in the social sphere and the performance of operating the social infrastructure to improve the population’s quality of life in the Russian regions. Particular attention has been paid to the role of organizational and administrative components, which include the regulation of social infrastructure institutions, planning, and programming that affect the performance of infrastructure facilities utilization. The goal of this study was to evaluate the effectiveness of social infrastructure management through the congruence of immediate results (dynamics of indicators for social services) and final results (parameters of the population’s quality of life). The working hypothesis of the study was a breach of infrasystemic principle in the infrastructural support for improving the population’s quality of life in the constituent entities of the Russian Federation because of the insufficient effectiveness of public administration. The work on this paper involved using a set of methodological approaches, such as structured, factorial, systemic, and evolutionary approaches, to substantiate the conceptual framework, prepare the method-based approaches, and determine the impact made by the changes in the parameters of social infrastructure facilities on provided services and shifts in the indicators of the population’s quality of life. The paper proposes a method-based approach to quantifying the effectiveness of organizational and administrative components by using the diagnostics of sufficiency in the implementation of infrasystemic principle for the operation of social infrastructure based on elasticity coefficients. The proposed approach and analytical data obtained in the areas, such as health care, education, trade, housing & utilities, culture & sport, allowed ranking the regions of the Ural Federal District and identifying the areas of insufficient effectiveness in the organizational and administrative mechanism used for improving the population’s quality of life as the basis for developing practical recommendations for the executive branch of constituent entities of the Russian Federation and adjustment of socioeconomic policies

Электродинамика многослойных цилиндрических направляющих систем

В работе исследованы электродинамические характеристики цилиндрических направляющих систем. Рассмотрены ограничения существующих математических моделей и пути их преодоления. Описан разработанный авторами универсальный метод анализа слоистых структур. Приведены результаты численного моделирования различных структур разработанным методом и их анализ. Даны рекомендации по выбору параметров открытых и закрытых линий передачи в зависимости от области использования. Предложены способы расширения рабочей полосы частот как в одноволновом режиме, так и при работе на высших типах волн.The electrodynamic characteristics of multilayered cylindrical waveguides are investigated. The limitations of existing mathematical models and ways to overcome them are discussed. Described by the authors universal method for the analysis of layered structures is presented. Also presented the results of numerical modeling of various structures designed by the method and their analysis. Recommendations on the choice of parameters of opened and closed transmission lines depending on the area of use are given. The way of widening the working frequency band in singlemode and multimode structures is considered

Development of mathematical model for calculation of characteristics of the circular metal waveguide with multilayer dielectric filling

Настоящая статья посвящена разработке математической модели и построению алгоритма для расчета постоянной распространения круглого волновода с металлическими стенками с поперечно неоднородным диэлектрическим заполнением. В основе математической модели лежат аппарат функций Грина и математический аппарат теории длинных линий для анализа многослойных структур. В статье описаны решения, использованные для создания алгоритмов, позволяющих применить описанную математическую модель для получения частотных зависимостей постоянной распространения.This article is dedicated to the development of mathematical model and building of an algorithm for calculation of propagation constant of circular metal waveguide with multilayer dielectric filling. Mathematical model is based on Green’s function methods and methods of circuits theory for analysis of multilayered structures. Ideas and solutions, which were used for algorithms created for applying of described mathematical model for obtaining of frequency dependences of propagation constant are described

Overiew of existing solutions excitation H₀₁ wave in the circular waveguide

В данной работе рассмотрены осесимметричная магнитная волна H₀₁ в круглом волноводе, особенности структуры ее поля, возможности применения аномальных свойств волны H₀₁ на практике, кратко рассмотрены существующие способы возбуждения волны Н₀₁ в круглом волноводе такие как: возбуждение с помощью противофазных элементов связи, возбуждение с помощью торцевых щелей связи между прямоугольным и круглым волноводами, преобразование типов волн посредством плавных переходов между волноводами с разными типами волн, возбуждение с помощью цилиндрической щелевой антенны, возбуждение за счет подключения прямоугольного волновода узкой стенкой на закороченный торец круглого волновода. Также рассмотрены пути для получения максимального коэффициента передачи и расширения рабочей полосы устройства возбуждения.In the article axisymmetric magnetic wave H₀₁ in the circular waveguide, features of its field structure, possible implementation of its anomalous characteristics in practical systems are considered. Also existent excitation devices, such as: excitation with antiphased coupling elements, excitation with the frontal slots between rectangular and circular waveguides, modes transformation using taper between waveguides with different modes, excitation using the cylindrical slot antenna, excitation with the rectangular waveguides narrow side on the short-circuited end of the circular waveguide are described. The ways of deriving a maximal coefficient of transmission and widening of the frequency band of the excitation device are proposed

Creative laboratory works on disciplene «Microwaves and antennas»

Представлены лабораторные работы по высокочастотной схемотехнике «Проектирование полосно-пропускающего микрополоскового фильтра» и «Согласование нагрузки с линией питания» дисциплины «Устройства СВЧ и антенны» направления подготовки «Радиотехника». Методика выполнения работ предусматривает расчет, изготовление и измерение характеристик разработанных устройств.Laboratory works on microwave design discipline "Microwaves and antennas" devoted to the analysis of microstrip filters and matching are presented. The technique of suggested works is based on microwave calculations, design and measurement of characteristics of developed devices

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes

Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter. Numerical changes, deletions and rearrangements of these chromosomes were radily visualized in metaphase spreads, as well as in early prophase and interphase nuclei. Complete chromosomes, deleted chromosomes and segments of translocated chromosomes were rapidly delineated in very complex karyotypes. Simultaneous hybridizations with additional subregional probes were used to further define aberrant chromosomes. Digital image analysis was used to quantitate the total complement of specific chromosomal DNAs in individual metaphase and interphase cells of each cell line. In spite of the fact that both glioma lines have been passaged in vitro for many years, an under-representation of chromosome 22 and an over-representation of chromosome 7 (specifically 7p) were observed. These observations agree with previous studies on gliomas. In addition, sequences of chromosome 4 were also found to be under-represented, especially in TC 593. These analyses indicate the power of these methods for pinpointing chromosome segments that are altered in specific types of tumors

Analysis of bow-tie antenna properties for brain microwave radiometry

В работе приведены результаты исследования одной из конструкций вибраторных антенн-аппликаторов, применяемых для контактных неинвазивных измерений собственного электромагнитного излучения головного мозга. Исследования проведены с помощью численного моделирования (гибридным методом конечных элементов и методом моментов), реализованного в программном пакете FEKO Suite 7.0. В этой среде была построена модель тканей головы человека и выполнена оптимизация антенны. В качестве критериев оптимизации выбраны: минимальный коэффициент отражения и максимальная напряженность электрического поля на глубине 50 мм. Рассчитаны частотные зависимости коэффициента отражения и мощности, сосредоточенной в различных тканях. Определено распределение плотности мощности в структуре. По полученным результатам сделан вывод, что антенна, оптимизированная по максимальной напряженности поля, обеспечивает прием большей доли мощности с внутренних слоев мозга.In this work, the results of a study on bow-tie antenna for contact noninvasive measurements of self-radiation of a human brain are presented. The investigation was carried out using numerical modeling (hybrid finite elements method and method of moments) by employing FEKO Suite 7.0. In this software the design of human head model was analyzed and the antenna optimization was conducted. The optimization goals are to minimize the reflection coefficient and maximize the electric field at a depth of 50 mm. The frequency dependencies of reflection coefficient and power collected from different tissues were calculated. The power density distribution was defined in the structure. It was found that the antenna, which was optimized in order to maximize electric field strength, provides better reception of energy from deep brain layers

Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes

Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors. We previously demonstrated that in Drosophila the deficiency of Pyridoxal 5' phosphate (PLP), the active form of vitamin B6, causes chromosome aberrations (CABs), one of cancer prerequisites, and increases hemolymph glucose content. Starting from these data we asked if it was possible to provide a link between the aforementioned studies. Thus, we tested the effect of low PLP levels on DNA integrity in diabetic cells. To this aim we generated two Drosophila models of type 2 diabetes, the first by impairing insulin signaling and the second by rearing flies in high sugar diet. We showed that glucose treatment induced CABs in diabetic individuals but not in controls. More interestingly, PLP deficiency caused high frequencies of CABs in both diabetic models demonstrating that hyperglycemia, combined to reduced PLP level, impairs DNA integrity. PLP-depleted diabetic cells accumulated Advanced Glycation End products (AGEs) that largely contribute to CABs as α-lipoic acid, an AGE inhibitor, rescued not only AGEs but also CABs. These data, extrapolated to humans, indicate that low PLP levels, impacting on DNA integrity, may be considered one of the possible links between diabetes and cancer

Measurement of Th1/Th2 serum cytokines by flow cytometry in classical Hodgkin lymphoma

O linfoma de Hodgkin clássico (LHC) é uma neoplasia com distúrbio na produção de citocinas. Estudos demonstram que o padrão anormal das citocinas no linfonodo acometido pela lesão contribui não somente com a proliferação das células malignas H-RS, como também com o característico infiltrado hiper-reativo que compõe o tecido no LHC. Esta disfunção pode ser observada tanto no quadro clínico dos pacientes, como nas características histopatológicas: sintomas B, deficiência na resposta imune celular, bandas de colágeno e eosinofilia. As concentrações séricas das citocinas Th1 (IL-2, TNF, INF-&#947;) e Th2 (IL-4, IL-5, IL-10) foram estudadas em 45 pacientes com LHC, ao diagnóstico, e em 34 doadores saudáveis, por citometria de fluxo (CBA - cytometric beads array). Houve aumento das concentrações das citocinas TNF (p<0,01), INF-&#947; (p<0,01), IL-4 (p=0,01), IL-5 (p<0,01) e IL-10 (p<0,01) dos pacientes quando comparados com o grupo controle. Não foi evidenciada diferença em relação a IL-2. Ao correlacionarmos as concentrações das citocinas Th1/Th2 com as variáveis clínico-laboratoriais dos pacientes, observou-se que níveis elevados da IL-10 (Th2) estão correlacionados com as variáveis que implicam em pior prognóstico: estádios III/IV (p=0,01), presença de sintomas B (p=0,04), hemoglobina < 10,5g/dL (p=0+,01), linfócitos <600 mm³ (p=0,01) e, de acordo com o IPI, os pacientes de alto risco (p=0,01). Por outro lado, níveis séricos elevados da IL-2 (Th1) foram encontrados em estádio I/II, quando comparados com III/IV (p=0,03), o que indica que a IL-2 diminui com a progressão da doença. Os resultados sugerem que a IL-10 possa estar regulando negativamente a resposta imune citotóxica (Th1) pela inibição da IL-2. Há uma possível associação entre progressão da doença e níveis elevados da IL-10. Esse estudo evidenciou que a utilização do CBA é factível na detecção das citocinas, e que as alterações encontradas podem estar envolvidas na biologia do LHC.Classical Hodgkin lymphoma (CHL) is a malignancy with an abnormal or unbalanced secretion/production of cytokines, which might support the growth of H-RS cells, their surrounding reactive bystander cells and may be responsible for the typical clinical and histopathologic features of CHL: systemic B symptoms, an apparent defect in cell-mediated immune response, tumor fibrosis and eosinophilic infiltrate. Serum concentrations of IL-2, IL-4, IL5, IL-10, TNF and IFN-&#947; (Th1/Th2) were measured in 45 patients at diagnosis of classical Hodgkin lymphoma and in 34 healthy controls by cytometric beads array (CBA). Levels of TNF (p<0.01), INF-&#947;(p<0.01), IL-4 (p=0.01), IL-5 (p<0.01) e IL-10 (p<0.01) were significantly higher in patients compared to the control group. No difference was observed for IL-2 between the two groups. On correlating Th1/Th2 cytokine concentrations with clinical risk factors, elevated IL-10 (Th2) levels are associated with variables that suggest worse prognoses including III/IV stage (p=0.01), B-symptoms (p=0.04), hemoglobin < 10.5g/dL (p=0.01), lymphocytes < 600/mm³ (p=0.01) and according to the seven-factored international prognostic score (IPI), a subset of patients with a particularly high risk of failure (p=0.01). Furthermore, the serum levels of IL-2 (Th1) were significantly higher in a group of I/II stage patients compared to III/IV patients (p=0.03) which implies that, the levels of IL-2 might decrease with disease progression. The elevated IL-10 levels in a subset of patients with poor clinical risk factors might down regulate a Th1 immune response by inhibiting IL-2 production causing survival disadvantage by suppression of the cytotoxic immune response against the tumor. This suggests an association between progression of CHL and higher levels of the IL-10 cytokine. This study showed that measurement of serum cytokines using the CBA methodology is highly reproducible, and that changes in concentrations seem to be involved in the biology of this diseas

WHF IASC Roadmap on Chagas Disease

Fil: Mitelman, Jorge E. Instituto Universitario de Ciencias de la Salud. Fundación Barceló; Argentina.Chagas Disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi, with some of the most serious manifestations affecting the cardiovascular system. It is a chronic, stigmatizing condition, closely associated with poverty and affecting close to 6 million people globally. Although historically the disease was limited to endemic areas of Latin America recent years have seen an increasing global spread. In addition to the morbidity and mortality associated with the disease, the social and economic burdens on individuals and society are substantial. Often called the ‘silent killer’, Chagas disease is characterized by a long, asymptomatic phase in affected individuals. Approximately 30% then go on develop chronic Chagas cardiomyopathy and other serious cardiac complications such as stroke, rhythm disturbances and severe heart failure