Infundebulectomy in management of uterine artery or uterine wall injury during complicated and difficult caesarean section: case series study

It is case series trying to save uterus in situation where one site of it is severely injured or in severe uncontrollable bleeding in one of the uterine arteries either during control of massive hemorrhage associated with friable tissues with severe adhesion, some cases of placenta accrete spectrum, some cases of uterine rupture and in caesarean section myomectomy

Systematic review of the safety of medication use in inpatient, outpatient and primary care settings in the Gulf Cooperation Council countries

Background Errors in medication use are a patient safety concern globally, with different regions reporting differing error rates, causes of errors and proposed solutions. The objectives of this review were to identify, summarise, review and evaluate published studies on medication errors, drug related problems and adverse drug events in the Gulf Cooperation Council (GCC) countries. Methods A systematic review was carried out using six databases, searching for literature published between January 1990 and August 2016. Research articles focussing on medication errors, drug related problems or adverse drug events within different healthcare settings in the GCC were included. Results Of 2094 records screened, 54 studies met our inclusion criteria. Kuwait was the only GCC country with no studies included. Prescribing errors were reported to be as high as 91% of a sample of primary care prescriptions analysed in one study. Of drug-related admissions evaluated in the emergency department the most common reason was patient non-compliance. In the inpatient care setting, a study of review of patient charts and medication orders identified prescribing errors in 7% of medication orders, another reported prescribing errors present in 56% of medication orders. The majority of drug related problems identified in inpatient paediatric wards were judged to be preventable. Adverse drug events were reported to occur in 8.5–16.9 per 100 admissions with up to 30% judged preventable, with occurrence being highest in the intensive care unit. Dosing errors were common in inpatient, outpatient and primary care settings. Omission of the administered dose as well as omission of prescribed medication at medication reconciliation were common. Studies of pharmacists’ interventions in clinical practice reported a varying level of acceptance, ranging from 53% to 98% of pharmacists’ recommendations. Conclusions Studies of medication errors, drug related problems and adverse drug events are increasing in the GCC. However, variation in methods, definitions and denominators preclude calculation of an overall error rate. Research with more robust methodologies and longer follow up periods is now required.Peer reviewe

Using ChatGPT for the Acquisition of Computational Thinking Skills: A Case of African Indigenous Games

This paper proposes using a ChatGPT-generated algorithm for an indigenous game to mediate the acquisition of computational thinking skills. The paper seeks to answer the question: How can the ChatGPT-mediated algorithm for indigenous games foster the acquisition of computational thinking skills? Using a Participatory Action Research approach, 19 collaborators from 11 African countries gathered 185 indigenous games. The paper focuses on one of those games that is played in all 11 countries. The paper concludes that involving collaborators, who are indigenous members of their communities and have experiential knowledge of the game, led to their acquisition of computational thinking skills

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors during ovarian stimulation reduces amount of gonadotropins required for optimum stimulation. The unique approach of reducing hyperestrogenism, as well as lowering amount of gonadotropins without affecting the number of mature ovarian follicles is an exciting strategy that could result in improvement in the treatment outcome by ameliorating the deleterious effects of the ovarian stimulation on follicular development, endometrial receptivity, as well as oocyte and embryo quality

Four hundred micrograms buccal misoprostol versus five units intravenous oxytocin in prevention of postpartum hemorrhage in elective caesarean section, randomized controlled study

Background: The number of studies has been increased about the use of misoprostol during caesarean delivery to prevent obstetric hemorrhage, but may be no study compare buccal misoprostol versus oxytocin in prevention of obstetric hemorrhage during and post cesarean section. Our study is done to compare buccal misoprostol 400 mcg versus oxytocin 5iu intravenous bolus in prevention of postpartum hemorrhage during and post elective cesarean section.Methods: A prospective registered, double blinded, randomized controlled trial Operative list or emergency unit at Obstetrics and Gynecology Department, Women Health Hospital, Assiut university, Egypt, comparing 77 patients in each group after verbal consent.Results: There was significant difference between both groups regarding total amount of blood loss (intra partum plus post-partum) 555.45±74.33 in oxytocin group versus522.6±88.76 in misoprostol group.Conclusions: Buccal misoprostol is more effective than intravenous infusion of oxytocin in reducing blood loss during elective cesarean delivery. However, occurrence of temporary side effects such as fever and chills was more frequent with the use of misoprostol. Clinical trial.gov: NCT03676621