Uridylation and adenylation of RNAs.

The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function. It has been recently discovered that nontemplated addition of uridine or adenosine to the 3' ends of RNAs occurs in different organisms ranging from algae to humans, and on different kinds of RNAs, such as histone mRNAs, mRNA fragments, U6 snRNA, mature small RNAs and their precursors etc. These modifications may lead to different outcomes, such as increasing RNA decay, promoting or inhibiting RNA processing, or changing RNA activity. Growing pieces of evidence have revealed that such modifications can be RNA sequence-specific and subjected to temporal or spatial regulation in development. RNA tailing and its outcomes have been associated with human diseases such as cancer. Here, we review recent developments in RNA uridylation and adenylation and discuss the future prospects in this research area

Role-Play Simulations and System Dynamics for Sustainability Solutions around Dams in New England

Research has shown that much of the science produced does not make its way to the decision-making table. This leads to a gap between scientific and societal progress, which is problematic. This study tests a novel science-based negotiation simulation that integrates role-play simulations (RPSs) with a system dynamic model (SDM). In RPSs, stakeholders engage in a mock decision-making process (reflecting real-life institutional arrangements and scientific knowledge) for a set period. By playing an assigned role (different from the participant’s real-life role), participants have a safe space to learn about each other’s perspectives, develop shared understanding about a complex issue, and collaborate on solving that issue. System Dynamic Models (SDMs) are visual tools used to simulate the interactions and feedback with a complex system. We test the integration of the two approaches toward problem-solving with real stakeholders in New Hampshire and Rhode Island via a series of two consecutive workshops in each state. The workshops are intended to engage representatives from diverse groups who are interested in dam related issues to foster dialogue, learning, and creativity. Participants will discuss a hypothetical (yet realistic) dam-decision scenario to consider scientific information and explore dam management options that meet one another\u27s interests. In the first workshop participants will contribute to the design of the fictionalized dam decision scenario and the SDM, for which we have presented drafts based on a literature review, stakeholder interviews, and expert knowledge. In the second workshop, participants will assume another representative\u27s role and discuss dam management options for the fictionalized scenario. We will report results related to the effectiveness to which this new knowledge production process leads to more innovative and collaborative decision-making around New England dams

Pairs of disjoint matchings and related classes of graphs

For a finite graph $G$, we study the maximum $2$-edge colorable subgraph problem and a related ratio $\frac{\mu(G)}{\nu(G)}$, where $\nu(G)$ is the matching number of $G$, and $\mu(G)$ is the size of the largest matching in any pair $(H,H')$ of disjoint matchings maximizing $|H| + |H'|$ (equivalently, forming a maximum $2$-edge colorable subgraph). Previously, it was shown that $\frac{4}{5} \le \frac{\mu(G)}{\nu(G)} \le 1$, and the class of graphs achieving $\frac{4}{5}$ was completely characterized. We show here that any rational number between $\frac{4}{5}$ and $1$ can be achieved by a connected graph. Furthermore, we prove that every graph with ratio less than $1$ must admit special subgraphs

Theoretical analysis of direct CPCP violation and differential decay width in D±→π±π+π−D^\pm\to \pi^\pm \pi^+\pi^- in phase space around the resonances ρ0(770)\rho^0(770) and f0(500)f_0(500)

We perform a theoretical study on direct $CP$ violation in $D^\pm\to \pi^\pm \pi^+\pi^-$ in phase space around the intermediate states $\rho^0(770)$ and $f_0(500)$. The possible interference between the amplitudes corresponding to the two resonances is taken into account, and the relative strong phase of the two amplitudes is treated as a free parameter. Our analysis shows that by properly chosen the strong phase, both the $CP$ violation strength and differential decay width accommodate to the experimental results.Comment: 15 pages, 5 figure

The Far-Infrared Background Correlation with CMB Lensing

The intervening large--scale structure distorts cosmic microwave background (CMB) anisotropies via gravitational lensing. The same large--scale structure, traced by dusty star--forming galaxies, also induces anisotropies in the far--infrared background (FIRB). We investigate the resulting inter--dependence of the FIRB and CMB with a halo model for the FIRB. In particular, we calculate the cross--correlation between the lensing potential and the FIRB. The lensing potential can be quadratically estimated from CMB temperature and/or polarization maps. We show that the cross--correlation can be measured with high signal--to--noise with data from the Planck Surveyor. We discuss how such a measurement can be used to understand the nature of FIRB sources and their relation to the distribution of dark matter.Comment: 9 pages, 5 figures, submitted to Ap

Acting out our dam future: science-based role-play simulations as mechanisms for learning and natural resource planning

Science often does not make its way into decisions, leading to a problematic gap between scientific and societal progress. To tackle this issue, our research tests a novel science-based negotiation simulation that integrates a role-play simulation (RPS) with a system dynamics model (SDM). In RPSs, stakeholders engage in a mock decision-making process (reflecting real-life institutional arrangements and scientific knowledge) for a set period. System dynamics models (SDMs) are visual tools used to simulate the interactions and feedback within a complex system. We test the integration of the two approaches with stakeholders in New England via a series of two consecutive workshops across two states. The workshops engage stakeholders from diverse groups to foster dialogue, learning, and creativity. Participants discuss a hypothetical (yet realistic) decision scenario to consider scientific information and explore dam management options that meet one another\u27s interests. In the first workshop, participants contributed to the design of the fictionalized dam decision scenario and the SDM. In the second workshop, participants assumed another representative\u27s role and discussed dam management options for the fictionalized scenario. This presentation will briefly report on the practical design of this science-based role-play, and particularly emphasize preliminary results of workshop outcomes, which were evaluated using debriefing sessions, surveys, concept mapping exercises, and interviews. Results will determine the extent to which this new knowledge production process leads to learning, use of science, and more collaborative decision-making about dams in New England and beyond

The behaviour of stacking fault energy upon interstitial alloying

Stacking fault energy is one of key parameters for understanding the mechanical properties of face-centered cubic materials. It is well known that the plastic deformation mechanism is closely related to the size of stacking fault energy. Although alloying is a conventional method to modify the physical parameter, the underlying microscopic mechanisms are not yet clearly established. Here, we propose a simple model for determining the effect of interstitial alloying on the stacking fault energy. We derive a volumetric behaviour of stacking fault energy from the harmonic approximation to the energy-lattice curve and relate it to the contents of interstitials. The stacking fault energy is found to change linearly with the interstitial content in the usual low concentration domain. This is in good agreement with previously reported experimental and theoretical data.111Ysciescopu