195 research outputs found
Non-Naturalism and Reasons-Firstism: How to Solve the Discontinuity Problem by Reducing Two Queerness Worries to One
Impossible Ethics: Do Population Ethical Impossibility Results Support Moral Skepticism and/or Anti‐Realism?
Djävulen enligt Katolska kyrkans officiella lära
Enligt Katolska kyrkans lära existerar ondskan objektivt, inte efter tycke och smak eller avhängig normer i olika samhällssystem. Dogmen, explicit angiven i Katolska kyrkans katekes, innebär att djävulen verkligen existerar i metafysisk mening och inte i metaforisk, mytologisk eller abstrakt betydelse utan som en närvarande ond makt med vilja och intelligens ur vilken ondskan utgår. Berättelsen om syndafallet orsakat av ängeln Lucifer tolkas däremot symboliskt. Det ligger i symbolens funktion att uttrycka något väsentligt på ett annat plan, i det här fallet hur ondskan påverkat mänskligheten, med andra ord varför ondskefulla handlingar, av människor och även av djävulen, tillåts av den allsmäktige guden. Grymhet och hat beskriver djävulen i Nya Testamentet, vid sidan av egenskaper som ofta handlar om splittring, lögn, död och mörker. Målet är att efter en temporär jordisk makt besegra Kristus genom att förvrida människans sinnen och intellekt i syfte att skapa förvirring kring moraliska värden
A Validation of the Swedish Colorectal Cancer Register – With Focus on Histopathology, Complications and Recurrences
Örvar Arnarson,1,* Peter Moberger,2,3,* Filip Sköldberg,4,5 Kenneth Smedh,2,3 Helgi Birgisson,4,5 Ingvar Syk1 1Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden; 2Centre for Clinical research Västerås, Uppsala University, Uppsala, Sweden; 3Department of Surgery Västmanlands Hospital Västerås, Västerås, Sweden; 4Gastrointestinal Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; 5Department of Surgery, Uppsala University Hospital, Uppsala, Sweden*These authors contributed equally to this workCorrespondence: Ingvar Syk, Department of Surgery, Skåne University Hospital, Malmö, SE-214 28, Email [email protected]: There is an urgent need to evaluate the quality of healthcare systems to improve and deliver high-quality care. Clinical registries have become important platforms for performance measurements, improvements, and clinical research. Hence, the quality of data in registries is crucial. This study aimed to assess the validity of data in the Swedish Colorectal Cancer Register (SCRCR).Methods: Seven hundred patients from 12 hospitals were randomly selected and proportionally distributed among three different hospital categories in Sweden using two-stage cluster sampling. Validity was assessed by re-abstracting data from the medical files of patients reported to the SCRCR in 2015. Data on histopathology, postoperative complications, and a 3-year follow-up were selected for validation. Re-abstracted data were defined as source data, and validity was defined as the proportion of cases in the SRCRC dataset that agreed with the source data. Validity was expressed as the percentage of exact agreement of non-missing data in both data sets, and Cohen´s kappa coefficient (κ) was used to measure the strength of the agreement.Results: The median agreement of the categorical histopathology variables was 93.4% (κ = 0.83). The general postoperative complication variable showed substantial agreement (84.3%, κ = 0.61). Likewise, the variable for overall cancer recurrence showed an almost perfect agreement (95.7%, κ = 0.86), whereas specific variables for local recurrence and distant recurrence displayed only moderate and fair agreement (85.9% and 89.1%, κ = 0.58 and 0.34, respectively).Conclusion: Validation of the SCRCR data showed high validity of pathology data and recurrence rates, whereas detailed data on recurrence were not as good. Data on postoperative complications were less reliable, although the incidence and Clavien–Dindo grading of severe complications (grade 3b or higher) were reliable.Keywords: quality registry, national registry, validation, colorectal cancer, Swedish registr
Sarcoma sinovial de extremidades com doença localizada ao diagnóstico: tratamento e padrões de recidiva em 57 casos
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