Experimental investigation of the flow evolution in the tributary of a 90° open channel confluence

Open channel and river confluences have received a lot of attention in hydraulic literature, because of the interesting flow phenomena observed. Features such as flow acceleration, curvature, separation, mixing and recovery are combined in the confluence area into a complex 3D flow pattern. Typically, the analysis of these features is started at the upstream corner of the confluence area, and the upstream main and tributary branches are considered to be the (uniform) upstream boundary conditions. However, several indications in literature suggest the existence of flow features upstream of the confluence corner. This paper confirms, by means of measurements in a laboratory, 90° confluence flume, considerable streamline curvature in the tributary branch, upstream of the confluence. Furthermore, it shows and quantifies velocity redistribution as well as local water surface super-elevation and depression in the tributary branch. Consequently, flow fea-ture analysis in confluences should start a considerable distance upstream of the confluence

Mechanical properties of Al-60 Pct SiCp composites alloyed with Mg

In the present work, the effect of an Mg addition on the mechanical properties of the Al-60 vol pet SiCp composites were investigated by uniaxial compression, three-point bending, impact and wear tests (composite-metal and composite-abrasive types). The composites were produced by the pressure-infiltration technique. The composition of the Al matrix was varied between 0 and 8 pet Mg. The mean diameter of the SiC particles was 23 mum. Upon addition of Mg, Mg2Si precipitated in the matrix and the amount of the porosity dramatically decreased. Mg-alloyed-matrix composites exhibited higher strength, lower toughness, and higher wear resistance than pure-Al-matrix composites. During composite-metal wear testina, wear progressed in two sequential periods (running-in and steady state). Weight loss during wear testing, decreased with increasing Mg content of the matrix. The degree of improvement of abrasive resistance depended on the abrasive-grain size. Above 200 degreesC, the composite-abrasive wear resistance decreased with increasing test temperature for all materials

Allogeneic Hematopoietic Cell Transplantation for Blastic Plasmacytoid Dendritic Cell Neoplasm: a CIBMTR analysis.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with a poor prognosis and considered incurable with standard conventional chemotherapy. Small observational studies have shown that allogeneic hematopoietic cell transplantation (allo-HCT) offers durable remissions in patients with BPDCN. We conducted an analysis of 164 patients with BPDCN from 78 centers who underwent allo-HCT between 2007-2018 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). Results: Median follow up of survivors was 49 months (range 6-121). 5-year overall survival (OS), disease-free survival (DFS), relapse, and non-relapse (NRM) rates were 51.2% (95% confidence interval [95%CI]: 42.5-59.8%), 44.4% (95%CI: 36.2-52.8%), 32.2% (95%CI: 24.7-40.3%), and 23.3% (95%CI: 16.9-30.4%), respectively. Disease relapse was the most common cause of death. On multivariate analyses, age ≥60 was predictive for inferior OS (hazard ratio [HR]= 2.16, 95% CI 1.35-3.46, p= 0.001), and higher NRM [HR= 2.19, 95% CI 1.13-4.22, p= 0.02]. Remission status at time of allo-HCT (CR2/PIF/Relapse vs CR1) was predictive of inferior OS [HR= 1.87, 95% CI 1.14-3.06, p= 0.01] and DFS [HR= 1.75, 95% CI 1.11-2.76, p= 0.02]. Use of myeloablative conditioning with total body irradiation (TBI) was predictive for improved DFS and reduced risk of relapse. Conclusion: Allo-HCT is effective in providing durable remissions and long-term survival in BPDCN. Younger age and allo-HCT in CR1 predicted for improved survival, while myeloablative conditioning with TBI predicted for less relapse and improved DFS. Novel strategies incorporating allo-HCT are needed to further improve outcomes