Quelques enseignements de l'expérience du GIRARDEL pour comprendre le concept développement local : [Preprint]

Le Groupe interdisciplinaire de Recherche pour l'Appui à la planification régionale et au développement local (GIRARDEL) est une initiative à travers laquelle l'Université rend plus visible, au-delà de ses missions traditionnelles, sa contribution au développement des sociétés de son environnement proche. Créé en 1999, il s'est fixé entre autres objectifs d'assister les collectivités décentralisées dans leurs actions de planification, de mise en oeuvre et de suivi-évaluation du développement local, par la production de connaissances et d'outils, à travers une approche interdisciplinaire et un partenariat inter-institutionnel. Cela traduit les intérêts scientifiques ainsi que la posture que le groupe ambitionne d'occuper dans le processus de mise en place d'un cadre d'échanges entre la Recherche et le Développement. L'intérêt scientifique du programme que le GIRARDEL met en oeuvre réside dans le renouvellement des méthodes et outils d'appui à la gestion décentralisée du territoire et de ses ressources, dans une perspective de faire jouer à la démarche d'appui son véritable rôle qui est celui d'accompagner le processus itératif et continu de prise de décision (Weber 1996). Dans la présente communication, nous examinerons i) le contexte de dissémination et de tentatives de mise en oeuvre du concept "développement local"; ii) la démarche du groupe pour réaliser l'objectif rappelé en supra; iii) l'analyse du concept et de ses implications. (Résumé d'auteur

Functionalization of amorphous nitrogenated carbon thin film electrodes for improved detection of cadmium vs. copper cations

International audienceThe specificity of a sensor relative to specific cations can be modified by functionalization of amorphous nitrogenated carbon thin film (a-C:Nx) electrodes. This surface modification was performed through the reduction of diazonium salts presenting different functionalities which could interact selectively with ions in solution. Cyclic voltammetry from +0.3 to −1.0 V vs. SCE was used for the grafting process leading to the formation of covalent CC bonds onto the film surface. The precursor concentration and number of cycles were optimized and correlated to the specificity and sensitivity for copper and/or cadmium ion detection. The coverage of the electrode was checked by cyclic voltammetry measurements using the Fe(CN)63−/4− system, interface charge transfer and contact angle. It showed that the electroreduction of diazonium salt and grafting of substituted aryl groups was effective on the surface of the a-C:Nx electrodes. A greater sensitivity of the electrode to Cd2+ was observed for the highest concentrations of precursors (4-amino benzene carboxylic acid (4-ABA)) compared to the pristine electrodes. Moreover, a marked decrease of cadmium sensitivity is noted after grafting but at the same time with a decreased influence of copper on the Cd2+ signal, indicating a better specificity of these functionalized sensor

A meta-population model to explain an endemic Rift Valley fever transmission in Northern Senegal. [P260]

Purpose: Certain Palaearctic biting midges have been implicated as vectors of bluetongue virus in northern Europe. Separation of two species (Culicoides obsoletus and C. scoticus) is considered difficult morphologically, with females often grouped together in entomological studies. Species specific identification is desirable to assess their roles in disease transmission or measure abundance during arboviral outbreaks. Our aim is to investigate whether morphometric identification techniques can be applied to female C. obsoletus and C. scoticus individuals trapped in different geographical regions and time periods during the year. Methods: Using light-suction traps, female C. obsoletus and C. scoticus were sampled from two locations in the UK, France and Spain. A total of 759 individuals were identified with a molecular assay using the cytochrome oxidase I gene. Fifteen morphometric measurements were then taken from the head, wings and abdomen of slide-mounted specimens. Multivariate analyses investigated whether a combination of these could lead to accurate species identification. Results: Principal component analyses revealed that the length and width of the smaller and larger spermathecae, and the length of, and width between, the chitinous plates can differentiate the species. These are all abdominal characteristics. Seasonal and geographic variation was observed for head and wing measurements, but not for those from the abdomen. Conclusions: Our results suggest that female C. obsoletus and C. scoticus individuals can be separated under a stereomicroscope using abdominal measurements. Although we show that morphometrics can be used to differentiate the species, this can be time-consuming and we recommend undertaking this using standardized subsampling of large catches. Relevance: This work highlights a new morphometric method of discriminating two of the main vector species of bluetongue virus. Such separations generally rely on molecular techniques, which can be expensive. Morphometric identifications may prove useful in outbreak situations when they can be quickly undertaken on a subsample of individuals to determine the proportions of each species present. (Texte intégral

Dyslipidemia, obesity and other cardiovascular risk factors in the adult population in Senegal

Introduction: According to the WHO, 50% of deaths worldwide (40.1% in developing countries) are due to chronic non-communicable diseases (NCDs). Of these chronic NCDs, cardiovascular diseases remain the leading cause of death and disability in developed countries. The Framingham study has shown the importance of hypercholesterolemia as a primary risk factor. In Senegal, the epidemiology of  dyslipidemia and obesity are still poorly understood due to the lack of comprehensive studies on their  impact on the general population. This motivated this study to look into the key epidemiologic and socio-demographic determinants of these risk factors. Methods: It was a cross-sectional descriptive epidemiological survey which included 1037 individuals selected by cluster sampling. Data were collected using a questionnaire following the WHO STEPwise approach. Socio-demographic, health and biomedical variables were collected. P value Results: The average age was 48 years with a female predominance (M: F of 0.6). The literacy rate was 65.2% and 44.7% of participants were from rural areas. The prevalence of hypercholesterolemia, hyperLDLemia, hypoHDLemia, hypertriglyceridemia and mixed hyperlipidemia were 56%, 22.5%, 12.4%, 7.11% and 1.9% respectively. One in four was obese (BMI> 30kg/m2) and 34.8% had abdominal obesity. The main factors significantly associated with dyslipidemia were obesity, urban dwelling, physical inactivity and a family history of dyslipidemia. Conclusion: The prevalence of dyslipidemia, obesity and other risk factors in the population was high needing immediate care for those affected and implementation of prevention strategies.Key words: Dyslipidemia, obesity, cardiovascular, risk factors, Saint Loui

Evaluation de l’état hydrique chez les patients hémodialysés chroniques : une étude transversale monocentrique: Assessment of the hydration status in chronic hemodialysis patients: a single-center cross-sectional study

Context and objective. For many practitioners, blood pressure is the main indicator of the hydration status of the chronic hemodialysis patient. The objective of this study was to assess the extent to which bioimpedance analysis (BIA) can assist in determining acute changes in fluid volume during the hemodialysis session. Methods. This was a 9-week longitudinal study. The total body water (TBW) was measured with a BIA analyzer, before and after 6 successive sessions. The ΔWeight was compared to the ΔTBW by calculating the P/V ratio (ΔWeight/ΔTBW) with the assumption that the dry weight is reached when P/V = 1. Results. The measurements made in 22 patients (46.6 years, 54.5% men, 92.3 months on dialysis) were reproducible. There was no statistically significant difference between ΔTBW and ΔWeight. However, at the individual level, significant differences had been observed. Using hypertension as a marker for a state of hyperhydration, a 31.8% agreement was noted between the P/V ratio and hypertension. Conclusion. Although the loss of water predicted by the BIA did not always correspond to the weight loss, BIA is a technique that can be used to assess the variations in TBW during the hemodialysis session in patients. Contexte et objectif. La pression artérielle est pour de nombreux praticiens, l’indicateur principal du statut hydrique du patient hémodialysé chronique. L’objectif de la présente étude était d’évaluer dans quelle mesure l’analyse d’impédance bioélectrique (BIA) pourrait aider à la détermination des variations aigues du volume hydrique au cours de la séance d’hémodialyse. Méthodes. Il s’agissait d’une étude de suivi longitudinal sur 9 semaines. Le volume total d’eau (VTE) a été mesuré par BIA, avant et après 6 séances. Le ΔPoids a été comparé au ΔVTE par le calcul du ratio P/V (ΔPoids / ΔVTE) dans l’hypothèse que le poids sec est atteint lorsque P/V = 1. Résultats. Les mesures faites chez 22 patients (46,6 ans, 54,5% hommes, 92,3 mois en dialyse) étaient reproductibles. Il n’y avait pas de différence statistiquement significative entre le ΔVTE et le ΔPoids. Cependant à l’échelon individuel des différences importantes étaient observées. En utilisant l’hypertension artérielle (HTA) comme marqueur d’un état d’hyperhydratation, une concordance de 31,8% était notée entre le ratio P/V et l’HTA. Conclusion. Bien que la perte d’eau prédite par la BIA ne corresponde pas toujours à celle du poids, la BIA est une technique qui peut être utilisée pour évaluer les variations du VTE au cours de la séance d’hémodialys

Cancer de la prostate localisé à haut risque de récidive:résultats de la prise charge

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Cancer de la prostate au Centre Hospitalier Universitaire Aristidie Le Dantec de Dakar : aspects épidemiologiques sur les cinq dernières années: Prostate cancer in Aristide Le Dantec hospital of Dakar: epidemiological aspects over the last five years

Context and objective. Prostate cancer represents a major public health issue, but data from sub-Saharan Africa are scarce. This study aimed to describe the epidemiological aspects of prostate cancer during the last five years in Aristide Le Decantec hospital of Dakar. Methods. it’s a retrospective and descriptive study involving 5 last years including all patients with histologically confirmed prostate cancer. The studied parameters were: prevalence, incidence, age, clinical stage, lethality and death rate. Results. Two hundred and thirty-three patients were enrolled. The prevalence of prostate cancer during the study period was 0.8%. Depending on the stage, metastatic cancer was the most common form with 45.9% of cases. The new cases were 199 with an average of 39.8 per year. The total incidence of prostate cancer over the study period was 0.7%. The mean age of the patients at the diagnosis time was 68.6 ± 9.2 years. The lethality was 0.5%. The global death rate was 0.9 ‰. The specific death rate was 0.9‰. The annual mortality rate was higher in 2017 (36.4%) compared to other years. Depending on the stage, the death rate was higher in metastatic stages patients. Conclusion. The incidence of prostate cancer is increasing in our medical center. Metastatic forms remain more common with higher death rate. Early detection campaigns for prostate cancer should be considered. Contexte et objectif. Le cancer de la prostate représente un enjeu majeur de santé publique et mais il reste très peu documenté en Afrique subsaharienne. L’objectif de cette étude était d’évaluer les aspects épidémiologiques du cancer de la prostate sur les 5 dernières années dans notre centre. Méthodes. Il s’agissait d’une étude documentaire et descriptive sur 5 ans ayant colligé les dossiers de tous les patients avec cancer de la prostate histologiquement confirmé. Les paramètres étudiés étaient : la prévalence, l’incidence, l’âge, le stade clinique, la létalité et la mortalité. Résultats. Deux cent trente-trois patients ont été retenus. La prévalence du cancer de la prostate durant la période étudiée était de 0,8%. En fonction du stade, le stade de cancer métastatique était prépondérant (45,9%). Les nouveaux cas étaient de 199, soit une moyenne de 39,8 nouveaux cas par an. L’incidence totale du cancer de la prostate sur la période étudiée était de 0,7%. L’âge moyen des patients au moment du diagnostic était de 68,6 ± 9,2 ans. Le taux létalité était de 0,5%. La mortalité globale était de 0,9‰. Le taux de mortalité annuelle était plus important en 2017 (36,4%) en comparaison aux autres années étudiées. En fonction du stade, le taux de mortalité était plus important pour les stades métastatiques. Conclusion. L’incidence du cancer de la prostate est en augmentation dans notre centre. Les formes métastatiques restent prédominantes assombrissant le pronostic vital. Des campagnes de dépistage précoce du cancer de la prostate sont à envisager

Antibiotic susceptibility profile of Streptococcus pneumoniae isolated from acute respiratory infection in Dakar: a cross sectional study

Streptococcus pneumoniae is a pathogen causing pneumonia, meningitis, otitis and bacteraemia. Nowadays, S. pneumoniae is developing antibacterial resistance, particularly for those with reduced susceptibility to penicillin. The objective of this study was to assess the susceptibility profile of S. pneumoniae strains isolated from acute respiratory infections (ARIs) in children younger than 5 years of age in Dakar, Senegal. S. pneumoniae strains were isolated from broncho-alveolar lavages (BALs), nasopharyngeal swabs, and middle ear secretion from children in the Paediatric Department of Abass Ndao University Teaching Hospital and Paediatric Department of Roi Baudouin Hospital in Dakar, Senegal. The strains were cultivated on Columbia agar supplemented with 5% of horse blood and gentamicin (6 mg/L). Antibiotic susceptibility testing was performed using E-test method. A total of 34 strains of S. pneumoniae were isolated and identified in this study, among them 7 strains (20.58%) showed penicillin-resistance. Antibiotics such as amoxicillin/clavulanic acid (MIC90=0.036 μg/mL), cefuroxim (MIC90=0.38 μg/mL), cefixim (MIC90=1.5 μg/mL), as well as macrolides (azithromycin MIC90=1.5 μg/mL, clarithromycin MIC90=0.125 μg/mL) and fluoroquinolone (levofloxacin MIC90=1 μg/mL, ofloxacin MIC90=2 μg/mL) were mostly active. However, all S. pneumoniae strains were resistant to sulfamethoxazole/trimethoprim (MIC90: 32 μg/mL). Except of S. pneumoniae strains penicillin-resistance or reduced susceptibility, most strains were susceptible to β-lactams antibiotics commonly used in ARI treatment. Continuous surveillance of antimicrobial resistance patterns of pneumococcus strains is still crucial for effective control of ARIs in children

Promotion of cardiovascular health in Africa: the Alliance for Medical Research in Africa (AMedRA) expert panel

This proposed scientific statement is focused on providing new insights regarding challenges and opportunities for cardiovascular health (CVH) promotion in Africa. The statement includes an overview of the current state of CVH in Africa, with a particular interest in the cardiometabolic risk factors and their evaluation through metrics. The statement also explains the main principles of primordial prevention, its relevance in reducing noncommunicable disease and the different strategies that have been effective worldwide. Also, the statement addresses challenges for implementing primordial prevention strategies in Africa, such as socioeconomic, cultural, lifestyle, and environmental factors, and highlights the importance of adapting strategies to the context. Finally, the statement recommends fundamental approaches for promoting CVH with the help of various partnerships and the involvement of communities