Mixed Medullary-Follicular Carcinoma of the Thyroid

Mixed medullary-follicular thyroid carcinoma is an uncommon tumor that consists of both follicular and parafollicular cells. Case.We report a 43-year-old woman with a palpable mass in the right side of the neck. Fine needle aspiration suggested a diagnosis of high grade anaplastic carcinoma that has been associated with papillary features. Total thyroidectomy was done in which histopathological examination showed diagnosis of medullary carcinoma. Immunohistochemical staining was positive for chromogranin, calcitonin, and thyroglobulin in tumoral cells. Conclusion. Mixed medullary-follicular thyroid carcinoma is a rare tumor. Diagnosis of these tumors with fine needle aspiration is very difficult and may lead to misdiagnosis. It is necessary to correlate the cytological finding with serum calcitonin and thyroglobulin. Also immunostaining for calcitonin and thyroglobulin confirms diagnosis

Determining the Efficiency of Carbonaceous Adsorbents in Removing Chromium (VI) from Aqueous Solution

The increase of various industries and the growth of the earth's population have caused various types of contamination in the environment. Anionic contaminants are one of the most important contaminants in water, which have many risks to human health and living organisms and also have many important environmental risks. Therefore, it is important to modify these resources. Studies showed that the use of biochar and metal-coated biochar effectively leads to the removal of a significant amount of contaminants from water and soil, but so far, the effect of carbon-metal composite on the removal of contaminants, especially anionic contaminants, has not been comprehensively investigated. In this research, the effect of biochar, metal-coated biochar and biochar-metal composite on the removal of chromium from water was investigated. Metal-coated biochars and various biochar-metal composites were prepared from the combination of metals (copper, iron and aluminum) with agricultural residues (rice straw) in raw form or as a biochar. The samples included Biochar, Copper-coated biochar, Aluminum-coated biochar, Iron-coated biochar, Copper composite, Aluminum composite, and Iron composite. In the first stage, the optimal conditions for contaminant removal were investigated, then an optimal amount of adsorbents and contaminant with a concentration of 20 mg/L and pH=6 were combined and shaken for three hours. until they reached equilibrium. After centrifugation and filtration, the final concentration of the contaminant was read and the chromium removal percentage was calculated. The results of the present research showed that the application of iron composite and iron-coated biochar could remove 90.32 and 93.71 percent of chromium pollutant from the aqueous solution, respectively. Therefore, the use of these adsorbents can remediate chromium-contaminated water

High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide

Abstract The aim of this study is to assess nucleoprotein expression of IKZF1/3 in patients with relapsed/refractory multiple myeloma (MM) who received lenalidomide-based therapy and correlated them with their clinical outcomes. A total of 50 patients diagnosed with MM were entered in the study with the median follow-up of 86.4 months. By immunohistochemistry (IHC), IKZF1 and IKZF3 were expressed in 72 and 58% of the cases, respectively. IKZF1 and IKZF3 expressions were associated with longer median progression free survival (P = 0.0029 and P < 0.0001) and overall survival (P = 0.0014 and P < 0.0001). IKZF3 expression also appears predicted a favorable response to the lenalidomide-based therapy

Automated ECG diagnosis based on nonlinear dynamics

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An Algorithm for Filtering Electrocardiograms to Improve Nonlinear Feature Extraction

This paper introduces an algorithm for removing high frequency noise components from electrocardiograms (ECGs) based on Savitzky-Golay finite duration impulse response (FIR) smoothing filter. The peaks of R waves and the points at which Q waves end and S waves start are detected for all beats. These points are used to separate the low amplitude parts of the ECG in each beat, which are most affected by high frequency noise. The Savitzky-Golay smoothing algorithm is then applied to these parts of the ECG and the resultant filtered signals are added back to their corresponding QRS parts. The effect of high frequency noise removal on nonlinear features such as largest Lyapunov exponent and minimum embedding dimension is also investigated. Performance of the filter has been compared with an equiripple low pass filter and wavelet de-noising