The effect of silver nanoparticles on composite shear bond strength to dentin with different adhesion protocols

In Dentistry, restorative materials and oral bacteria are believed to be responsible for restoration failure. To make long-lasting restorations, antibacterial agents should be made. Inorganic nanoparticles and their nano composites are applied as good antibacterial agents. Objective The purpose of this study was to investigate the effect of silver nanoparticles on composite shear bond strength using one etch and rinse and one self-etch adhesive systems. Material and Methods Silver nanoparticles were prepared. Transmission electron microscope and X-ray diffraction were used to characterize the structure of the particles. Nanoparticles were applied on exposed dentin and then different adhesives and composites were applied. All samples were tested by universal testing machine and shear bond strength was assesed. Results Particles with average diameter of about 20 nm and spherical shape were found. Moreover, it was shown that pretreatment by silver nanoparticles enhanced shear bond strength in both etch and rinse, and in self-etch adhesive systems (p≤0.05). Conclusions Considering the positive antibacterial effects of silver nanoparticles, using them is recommended in restorative dentistry. It seems that silver nanoparticles could have positive effects on bond strength of both etch-and-rinse and self-etch adhesive systems. The best results of silver nanoparticles have been achieved with Adper Single Bond and before acid etching

The effect of organizational and extra-organizational factors on the empowerment of employees with the role of organizational learning moderator (Case of Study: Nezaja Artillery and Missile Training Center)

Objective: One of the most important tasks of human resources management in the army is to cultivate efficient and capable forces that can provide the defense needs of the country in the field of human resources according to the existing threats. In this sense, the quality of the trained forces in this organization, which indicates the proportionality of these resources with threats, is an important factor in determining the effectiveness of the organization. This study was conducted with the aim of investigating the effect of organizational and extra-organizational factors on employee empowerment, and the organizational learning variable played a moderating role in the causal relationship between organizational factors and empowerment.Method: The target population of this research includes all the employees of the Artillery and Missile Training Center of the Islamic Republic of Iran Army, 178 of whom were selected and studied through three questionnaire tools: organizational factors, organizational learning, and empowerment. For data analysis, descriptive correlation strategy and structural equation model were used with the help of SPSS and Smart PLs3 statistical software.Findings: Based on the findings, the variable of organizational learning strengthens the causal relationship between the variable of organizational factors and empowerment, which shows the importance of this variable in adjusting the relationship between organizational and external factors and empowering employees.Conclusion: The result of the research indicates the confirmation of the effect of organizational factors on empowerment and the rejection of the effect of non-organizational factors on the empowerment of the studied employees. Meanwhile, the moderator of organizational learning has strengthened the causal relationship between the two variables of organizational factors and empowerment, which shows the importance of this moderator in the process of improving employee empowerment. Has i

Examining Mulla Sadra's Opinion about Ghazali's Opinion on the Resurrection of the Body

One of the viewpoints about bodily resurrection is Ghazali's theory, which believes in the alike of the otherworldly body and the worldly body. On the other hand, Mulla Sadra explained the physical resurrection according to the principles of his philosophical system and concluded that the soul and the body will be the same. Mulla Sadra criticizes Ghazali's theory; He considers the most important criticism of Ghazali's theory to be that it is not compatible with rational principles and that his opinion requires reincarnation. In this article, we have examined Mulla Sadra's criticisms of Ghazali on the issue of physical resurrection, and following that, we have stated the similarities and differences between the theories of these two thinkers. The similarities and differences between these two theories can be found through the method of intellectual analysis and through the analysis of Mulla Sadra's discussion on Ghazali. Similarities can be seen between the theory of these two thinkers regarding the survival of the soul after death and the intellectual celibacy of the soul, although these two theories are distinct and different from each other in their approach to the nature of the human soul and the relationship between the soul and the body. Therefore, in the quality of the afterlife body, they interpreted it as the similarity or objectivity of the afterlife body with the worldly body, but this difference is in the interpretation, and in fact, the meaning of these two thinkers is the same thing, and that is that the identity between the person in the afterlife and the world is established

Cell Adhesion Molecules and Cancer

Theodor Boveri in 1914 recognized the significance of changes in the adhesion of tumor cells to the development of cancer. Cell adhesion is essential in all aspects of in verte-brate cells such as cell growth, cell migration and cell differentiation. The majority of adhesion molecules fall into one of four families: cadherins, integrins, immunoglobulin superfamily (IgSF) and selectins. The cadherins are a family of homophilic CAMs (cell adhesion moleculs), Ca2+ dependent. The most important members of cadherins are E-cadherins (epithelial), P-cadherins (placental) and N-cadherins (neural). Immunoglobu-lin superfamily CAMs (IgSF CAMs) are either homophilic or heterophilic and bind in-tegrins, growth factor receptors cadherins or different IgSF CAMs. The integrins are a family of heterophilic CAMs that bind IgSF CAMs or the extracellular matrix. The se-lectins are a family of heterophilic CAMs that bind fucosylated carbohydrates, e.g. mu-cins. They are calcium-dependent. The three family members are E-selectin (endothelial (, L-selectin (leukocyte) and P-selectin (platelet). Recent experimental results indicate that, as well as mediating intercellular and cell–matrix interactions, cell-adhesion mole-cules also directly modulate signal transduction. Changes in the expression or function of cell-adhesion molecules can therefore contribute to tumor progression via altering the adhesion status of the cell or affecting cell signaling. The ability to colonize a specific organ has been correlated with the preferential adhesion of the cancer cells to endotheli-al cells derived from the target organ. This review summarizes recent findings about role of adhesion molecules in the tumor progression

Study the absorption process of cadmium ions by Fe3O4/L-methionine/graphene oxide and graphene Aerogel nanocomposites from aqueous environments

In this research, the synthesis of L/Fe3O4-methionine and graphene oxide and graphene aerogel nanocomposites (Fe3O4/L-Met/GO, Fe3O4/L-Met, Fe3O4/L-Met/GA) was carried out. Then the structure of the synthesized nanocomposites was confirmed by FT-IR, FE-SEM and BET analyses. Then, the effect of different experimental parameters such as initial pH and contact time on the process of cadmium surface adsorption were investigated. The results showed that the highest percentage of cadmium absorption (90%) occurred at Ph=6 by Fe3O4/L-Met/GA nano adsorbent. Therefore, the cadmium (Cd2+) absorption capacity by Fe3O4/L-Met/GA nanocomposite (212.31 mg/g) is higher than the cadmium (Cd2+) absorption capacity by Fe3O4/L-Met nanocomposites (201.23 mg/g). ) Obtained. Adsorption kinetics data showed excellent fit with pseudo-second-order models (R2>0.99) and Freundlich isotherm models.showed high adsorption capacity towards Cd2+ (212.31 mg/g), which was significantly higher than Fe3O4/L-Met (201.23 mg/g). Finally, adsorption kinetics, isotherm studies were investigated. Absorption data showed excellent fit with quasi-second order models (R2> 0.99) and Freundlich isotherm models

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin

Effect of Exposure to Quran Recitation on Cell Viability, Cell Migration, and BCL2L12 Gene Expression of Human Prostate Adenocarcinoma Cell Line in Culture

Background and Objectives: Prostate cancer is the third most important cause of cancer deaths and one of the most common cancers in the world. Given the limited knowledge on environmental sounds and their effects, the important role of sounds is neglected in every culture across the world. The aim of this study was to investigate the impact of Quran recitation on prostate cancer cell line (PC-3) and compare it with the effects of cisplatin. Methods: The effects of cisplatin and Quran recitation on the viability and migration capacity of PC-3 cells were investigated by evaluating BCL2L12. In addition, mRNAs were assessed by real-time polymerase chain reaction (RT-PCR). Gene expressions of BCL2L12 and TBP were investigated as target and internal control genes, respectively. Results: The results of the in vitro assay showed a considerable inhibitory effect of Quran recitation on the proliferation and migration of PC-3 cells. Furthermore, the significant inhibitory effects of cisplatin on the proliferation and migration of PC-3 cells exposed to Quran recitation was more than that of the PC-3 cells only treated with cisplatin. Results of quantitative real time PCR demonstrated that the gene expression of BCL2L12 was significantly down regulated in PC-3 cells treated by cisplatin and those exposed to both cisplatin and Quran recitation. Conclusion: This was the first report about the direct effects of Quran recitation on non-auditory cells in culture. The results of this study suggested that Quran recitation could alter cell proliferation via the down regulation of BCL2L12 and migration of PC-3 cells. &nbsp