4E assessment of power generation systems for a mobile house in emergency condition using solar energy: a case study

In this study, a solar parabolic trough concentrator (PTC) was evaluated as a heat source of a power generation system based on energy (E1), exergy (E2), environmental (E3), and economic (E4) analyses. Various configurations of power generation systems were investigated, including the solar SRC (SRC) and solar ORC (ORC). Water and R113 were used as heat transfer fluids of SRC and ORC system, respectively. It should be mentioned that the proposed solar systems were evaluated for providing the required power of a mobile house in an emergency condition such as an earthquake that was happened in Kermanshah, Iran, in 2016 with many homeless people. The PTC system was optically and thermally investigated based on sensitivity analysis. The optimized PTC system was assumed as a heat source of the RC with two various configurations for power generation. Then, the solar RC systems were investigated based on 4E analyses for providing the power of the mobile house based on various numbers of solar RC units. It was concluded that the solar SRC system could be recommended for achieving the highest 4E performance. The highest value of its energy efficiency was found at 24.60% and of his exergy at 26.37%. On the other hand, the ORC system has energy and exergy efficiencies at 17.64% and 18.91%, respectively, which are significantly lower than the efficiencies of the SRC system. The optimum heat source temperature for the SRC system is found at 650 K, while for the ORC system at 499 K. Moreover, the best economic performance was found with the SRC system with a payback period of 7.47 years. Finally, the CO2 mitigated per annum (φCO2) was estimated at 5.29 (tones year−1), and the carbon credit (ZCO2) was calculated equal to 76.71 ($ year−1)

POSITIVE PERSPECTIVES MATTER: ENHANCING POSITIVE ORGANIZATIONAL BEHAVIOR

This paper is an attempt to shed light on positive organizational behavior and the significance of three psychological perspectives in fulfilling positivity in the workplace, namely the attribution theory of motivation and emotion, the Broaden-and-Build theory, and the emotional intelligence theory. The paper is based on the assumption that these three theories help individuals understand the causes and reactions of other human behavior. In organizations, the way people perceive daily responses or interactions affects everyone's judgments and actions. Awareness of self-emotions and appropriate attributions of others' reactions would enhance positive behavior within organizations. Reference to the most relevant literature review is discussed and linked to these three theories as well as the positive impact they create when interrelated with cultural awareness. The main points in each theory are highlighted, followed by a claim that justifies their possible effectiveness in contributing to positive organizational and employee behavior. According to this paper, organizing workshops within the work environment that address positivity theories and their impact on positive behavior will help bridge the gap between individual and organizational cultural values, increase self-awareness and understanding, and boost togetherness, collaboration, and positive attitudes toward others

Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors

Series of diaryl-based pyrazole and triazole derivatives were designed and synthesized in a facile synthetic approach in order to produce selective COX-2 inhibitor. These series of derivatives were synthesized by different reactions like Vilsmeier–Haack reaction and click reaction. In vitro COX-1 and COX-2 inhibition studies showed that five compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 values in 0.551–0.002 μM range. In the diarylpyrazole derivatives, compound 4b showed the best inhibitory activity against COX-2 with IC50 = 0.017 μM as one of the N-aromatic rings was substituted with sulfonamide and the other aromatic ring was unsubstituted. However, when the N-aromatic ring was substituted with sulfonamide and the other aromatic ring was substituted with sulfone (compound 4d), best COX-2 selectivity was achieved (IC50 = 0.098 μM, SI = 54.847). In the diaryltriazole derivatives, compound 15a showed the best inhibitory activity in comparison to all synthesized compounds including the reference celecoxib with IC50 = 0.002 μM and SI = 162.5 as it could better fit the extra hydrophobic pocket which is present in the COX-2 enzyme. Moreover, the docking study supports the obtained SAR data and binding similarities and differences on both isozymes

Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors

Series of diaryl-based pyrazole and triazole derivatives were designed and synthesized in a facile synthetic approach in order to produce selective COX-2 inhibitor. These series of derivatives were synthesized by different reactions like Vilsmeier–Haack reaction and click reaction. In vitro COX-1 and COX-2 inhibition studies showed that five compounds were potent and selective inhibitors of the COX-2 isozyme with IC50values in 0.551–0.002 μM range. In the diarylpyrazole derivatives, compound4bshowed the best inhibitory activity against COX-2 with IC50 = 0.017 μM as one of theN-aromatic rings was substituted with sulfonamide and the other aromatic ring was unsubstituted. However, when theN-aromatic ring was substituted with sulfonamide and the other aromatic ring was substituted with sulfone (compound4d), best COX-2 selectivity was achieved (IC50 = 0.098 μM, SI = 54.847). In the diaryltriazole derivatives, compound15ashowed the best inhibitory activity in comparison to all synthesized compounds including the reference celecoxib with IC50 = 0.002 μM and SI = 162.5 as it could better fit the extra hydrophobic pocket which is present in the COX-2 enzyme. Moreover, the docking study supports the obtained SAR data and binding similarities and differences on both isozymes.</jats:p