Effectiveness of Hybrid Project Management in Remote Work Environment

This assignment reflects on the process of developing and publishing a thesis, highlighting the challenges encountered, strategies employed to overcome them, and the personal growth achieved throughout the journey. Key insights are drawn from the experience, including how the understanding of the research topic evolved over time and practical advice for future students embarking on similar academic endeavors. The document also provides evidence of initiating the thesis publication process on the Harrisburg University Digital Commons platform, demonstrating a crucial step in sharing scholarly work with a broader audience. This reflection emphasizes the transformative nature of the thesis process, fostering intellectual development and equipping students with essential research and project management skills. By addressing challenges and providing practical recommendations, this work aims to support and guide peers in successfully navigating their thesis projects

Role of Cissus quadrangularis in Bone Fracture and Osteoporosis- A Review

Osteoporosis is a skeletal disorder causing bone mass reduction and deterioration, increasing fracture risk. Treatments include supplementation, Hormone Replacement Therapy (HRT), and bisphosphonates. HRT can decrease hip and spine fracture risk when administered correctly, but can also cause thromboembolism, withdrawal bleeding, and breast cancer. Alternative therapies like bisphosphonates may also be effective. Given the limitations and side effects of these therapies, there arises a pressing need to explore alternative options to prevent and treat osteoporosis while promoting improved bone health. The growing interest in herbal medicines has arisen from their perceived safety compared to chemically synthesized drugs. Hence, there exists a need for an effective compound of Cissus quadrangularis Linn (CQL) that specifically can exhibit the desired attributes, including the prevention and treatment of illnesses and diseases associated with bone health, complemented by the influence of effective fracture healing through its anabolic steroid properties. Cissus quadrangularis contains various active compounds, including flavonoids, steroids, and triterpenes. These compounds are responsible for numerous health benefits, such as the flavonoids in CQL, which have anti-inflammatory and antioxidant properties for treating various conditions, including pain, arthritis, and asthma. Cissus quadrangularis has garnered attention in scientific research for its potential role in managing obesity and related metabolic disorders. This article reviews Cissus quadrangularis Ayurvedic usage, Patents on CQL for bone health and osteoporosis, CQL Marketed Products, Chemical Constituents of CQL in Bone healing, Osteoblasts and osteoporosis and Preclinical and clinical studies of CQL in Osteoporosis and Bone fractures

Evaluation of Oxidative Stress in the Pathogenesis of Preeclampsia by Studying the Changes in Plasma Malondialdehyde and Ceruloplasmin.

Preeclampsia is a human pregnancy specific, multi system disorder that Is characterized by hypertension and proteinuria1. Inspite of intensive effort to Identify the pathophysiological mechanism neither a specific cause nor a Pathogenesis has been identified. Roes, EM et al.hypothesised that endothelial dysfunction plays a major Role in preeclampsia2. Carl A. Hubel reviewed the role of oxidative stress in vascular Endothelial cell damage and also recorded increased level of lipid peroxidation Products in preeclampsia3. Atamer Y et al. Reported that the plasma antioxidant activity in Preeclampsia is defective, and could be the causative factor that is responsible For endothelial damage4. Gutteridge JMC et al. Reported that Ceruloplasmin is the major plasma Antioxidant and its activity is found to decrease in preeclampsia5. The increased Lipid peroxidation along with decreased ceruloplasmin activity may play a role In pathogenesis of preeclampsia.6 The present study was carried out to determine the level of plasma, Malondialdehyde [MDA] as a marker of lipidperoxidation and ceruloplasmin as An antioxidant against lipid peroxidation. By performing the above parameters In preeclampsia the antioxidant status and oxidative stress were studied

Zastosowanie kliniczne świeżo mrożonego osocza w szpitalu referencyjnym w Indiach

Background. Increased utilization of fresh frozen plasma (FFP) over the last decade hascaused a rising trend in its unjustified usage exposing recipients to both infectious and non--infectious hazards. The aim of the study was to observe the pattern of clinical use of plasmaat a tertiary care hospital from India.Material and methods. Prospective analysis of all the requests raised for plasma was carriedout. Indicators namely homogeneity of the requisition forms, patient demographics, indicationsfor transfusion, dosage, pre-transfusion coagulation parameters and adverse events werenoted. Appropriateness was defined based on compliance to both national and internationalstandards. Data was analyzed using SPSS version 20 (IBM, USA).Results. Total nine hundred ninety eight patients (Males: 66%) received 4991 units ofplasma at an average of two episodes per patient. Majority were adults 83.6% (n = 835).Primary users were internal medicine (32%) and plastic surgery (17%) respectively. Mostcommon indication was bleeding with coagulopathy seen in 41% (411/998) patients. Averageplasma volume administered was 456.2 ± 287.4 (17 to 2800) mL per episode. Pre--transfusions INR value was available in only 63.2% (n = 1317) episodes. Overall, 56% (n= 1169) episodes were deemed appropriate. Total 0.28% plasma related adverse reactionswere seen and reported to the national hemovigilance database. Mortality in the study groupwas 7.2%.Conclusion. Existing transfusion practices for plasma use were moderately compliant withthe standards. Commonest indications for inappropriate FFP use were for low protein statesand prophylaxis without any evidence of bleeding.Wstęp. W ciągu ostatniej dekady znacznie zwiększyło się zużycie świeżo mrożonego osocza(fresh frozen plasma, FFP), co spowodowało rosnącą tendencję do nieuzasadnionego stosowaniaFFP, a tym samym narażenie pacjentów na ryzyko związane z zakażeniami i niezakaźnymi powikłaniami. Badanie przeprowadzono w celu zaobserwowania, w jaki sposób stosuje sięFFP w referencyjnym szpitalu w Indiach.Materiał i metody. Przeanalizowano w sposób prospektywny wszystkie przypadki zamówieńosocza. Stosowano jednorodne formularze zamówienia i odnotowano dane demograficznechorych, wskazania do transfuzji, dawkę, parametry krzepliwości krwi przed transfuzją orazzdarzenia niepożądane. Prawidłowe stosowanie definiowano jako zgodność z krajowymi i międzynarodowymistandardami. Do analizy danych użyto oprogramowania SPSS, wersja 20(IBM, Stany Zjednoczone).Wyniki. Ogółem 998 chorym (66% mężczyzn) podano 4991 jednostek osocza, a średnia liczbatransfuzji na pacjenta wynosiła 2. Większość stanowiły osoby dorosłe (83.6%; n = 835).Największą grupę stanowili pacjenci internistyczni (32%) i osoby poddające się zabiegom z zakresuchirurgii plastycznej (17%). Najczęstszym wskazaniem było krwawienie z koagulopatiąobserwowane u 41% (411/998) chorych. Średnia objętość podanego osocza wynosiła 456,2± 287,4 (17 do 2800) ml na transfuzję. Wartość INR przed transfuzją była dostępna tylkow 63,2% (n = 1317) epizodów. Ogółem, 56% (n = 1169) epizodów uznano za prawidłowe.W 0,28% przypadków zaobserwowano działania niepożądane i zgłoszono je do krajowej bazynadzoru hematologicznego. Odnotowano 72 przypadki zgonów (7,2% chorych).Wnioski. Stosowana praktyka dotycząca transfuzji osocza była umiarkowanie zgodna ze standardami.Najczęściej stwierdzanymi nieprawidłowościami było stosowanie FFP w przypadkuniedoborów białkowych i w ramach profilaktyki przy braku jakichkolwiek oznak krwawienia

An integrated smart water management system for efficient water conservation

Water is a fundamental resource that sustains life, supports ecosystems, and plays a crucial role in various natural processes on earth. Water wastage is a major problem in the world, with a variety of causes including leaks in infrastructure and inefficient usage methods. A typical cause of water wastage is overflow from reservoirs or tanks as a result of poor maintenance or monitoring. This paper proposes a novel water resource management using internet of things (WARM-IoT) system to monitor and regulate the water level remotely by integrating IoT technology with demand side management (DSM) strategies, real-time monitoring of water levels has been achieved. The approach utilizes an ultrasonic sensor and Raspberry Pi for data acquisition and processing, fuzzy logic for decision-making, and an Android app for remote monitoring and control. The WARM-IoT assesses the system's performance, showcasing its efficacy in managing water levels and lowering electricity expenses. By analyzing consumption costs under different activation timings, significant potential for cost savings is observed, with a notable reduction of up to 6% in electricity expenses. Overall, the proposed WARM-IoT offers a comprehensive solution to water wastage and inefficient electricity usage in water management systems

Idiopathic multilocular thymic cyst-an incidental anterior mediastinal mass

Acquired thymic cyst are multilocular and they occur de novo or in association with mediastinal neoplasm, systemic autoimmune diseases and trauma. Here, we report a case of acquired multilocular thymic cyst due to non-specific inflammatory etiology in a 42-year old gentleman and our approach to diagnosis and management of anterior mediastinal mass. With no specific clinical symptom, he was diagnosed with anterior mediastinal mass incidentally by imaging studies. Definitive diagnosis of multilocular thymic cyst was obtained by tissue diagnosis of the anterior mediastinal mass resected during the surgery