A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods

Manual mapping of drumlins in synthetic landscapes to assess operator effectiveness

Mapped topographic features are important for understanding processes that sculpt the Earth's surface. This paper presents maps that are the primary product of an exercise that brought together 27 researchers with an interest in landform mapping wherein the efficacy and causes of variation in mapping were tested using novel synthetic DEMs containing drumlins. The variation between interpreters (e.g. mapping philosophy, experience) and across the study region (e.g. woodland prevalence) opens these factors up to assessment. A priori known answers in the synthetics increase the number and strength of conclusions that may be drawn with respect to a traditional comparative study. Initial results suggest that overall detection rates are relatively low (34–40%), but reliability of mapping is higher (72–86%). The maps form a reference dataset

The effectiveness of Two-Risk Levels containment measures applied during Portuguese COVID-19 second wave: an interrupted time series study

Trabalho de projeto de mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de CiênciasIn order to contain COVID-19 disease dissemination, originated by SARS-CoV-2 viral infection, the Portuguese government took several actions during the country’s second wave. One of such measures was the separation of municipalities into two risk levels, according to their 14 day-cumulative incidence, with containment measures applied according to each level. The objective of this master’s project was to evaluate if this type of targeted containment measures were effective in halting or even reducing the pandemic growth. The aforementioned evaluation was performed using two variables, regularly used to monitor the estate of the pandemic, the number of daily positive COVID-19 tests and the number of daily deaths due to SARS-CoV-2 infection. Using an Interrupted Time Series analysis, both variables were modelled trough an impact model with the objective of comparing the pre intervention trend with the post intervention trend. The results show a significant negative change in the regression slope, either for daily tests (p-value < 0.001) as for deaths (p-value < 0.001). The Two-Risk level division of the Portuguese municipalities and application of containment measures according to the level was effective in controlling viral dispersion, either in reducing the number of positive tests as well as the number of daily deaths. Although expected that this type of containment measures will not produce the same level of control as the general confinement of the population, it can still create a significant positive impact while having an estimated smaller socioeconomic impact compared to the impact generated by a full lockdown. As such, targeted containment measures should be considered in future COVID-19 outbreaks as well as in controlling the dissemination of future viruses with pandemic potential

The effectiveness of Two-Risk Levels containment measures applied during Portuguese COVID-19 second wave: an interrupted time series study

Trabalho de projeto de mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de CiênciasIn order to contain COVID-19 disease dissemination, originated by SARS-CoV-2 viral infection, the Portuguese government took several actions during the country’s second wave. One of such measures was the separation of municipalities into two risk levels, according to their 14 day-cumulative incidence, with containment measures applied according to each level. The objective of this master’s project was to evaluate if this type of targeted containment measures were effective in halting or even reducing the pandemic growth. The aforementioned evaluation was performed using two variables, regularly used to monitor the estate of the pandemic, the number of daily positive COVID-19 tests and the number of daily deaths due to SARS-CoV-2 infection. Using an Interrupted Time Series analysis, both variables were modelled trough an impact model with the objective of comparing the pre intervention trend with the post intervention trend. The results show a significant negative change in the regression slope, either for daily tests (p-value < 0.001) as for deaths (p-value < 0.001). The Two-Risk level division of the Portuguese municipalities and application of containment measures according to the level was effective in controlling viral dispersion, either in reducing the number of positive tests as well as the number of daily deaths. Although expected that this type of containment measures will not produce the same level of control as the general confinement of the population, it can still create a significant positive impact while having an estimated smaller socioeconomic impact compared to the impact generated by a full lockdown. As such, targeted containment measures should be considered in future COVID-19 outbreaks as well as in controlling the dissemination of future viruses with pandemic potential

Diario puntual de la fiestas sagradas...

Mode of access: Internet

SICAP Sistema de información web para el control del acompañamiento psicopedagógico y fortalecimiento de la inserción universitaria en la dirección del primer año de la Corporación Universitaria Minuto de Dios sede Soacha

Este documento pretende exponer el proceso de construcción y desarrollo de SICAP, el Sistema de Información Web para el control del acompañamiento psicopedagógico y de la inserción universitaria en la dirección de primer año de la Corporación Universitaria Minuto de Dios sede Soacha. Se presenta en cuatro capítulos. En el primero se muestran los problemas y soluciones encontrados durante la investigación y se justifica la aplicación de SICAP en la dirección de primer año, en el segundo capítulo se aborda todo el respaldo teórico y conceptual relacionado con la inserción y deserción en los estudiantes de Primer Año, en la tercera etapa del proyecto se exponen la metodologías utilizadas durante el desarrollo y construcción de SICAP y finalmente se muestra todo el diseño técnico realizado para la construcción de la página web. SICAP surgió como una solución a los problemas que se tienen en el área de bienestar universitario, el proyecto pretende fortalecer y apoyar el desarrollo de la institución en los ámbitos social divulgando la información sobre los servicios que ofrece bienestar universitario y la dirección de primer año y apoyando la inserción a la vida universitaria en los estudiantes de primer año, académico ya que proporciona al estudiante de métodos de estudio y de datos relevantes sobre su carrera profesional y tecnológico por que promovería la investigación en el tema de la inserción y la deserción universitaria por medio de la aplicación de encuestas en la página web a los estudiantes de primer año