Successfully controlling malaria in South Africa

PKFollowing major successes in malaria control over the past 75 years, South Africa is now embarking on a malaria elimination campaign with the goal of zero local transmission by the year 2018. The key control elements have been intensive vector control, primarily through indoor residual spraying, case management based on parasitological diagnosis using evidence-based drug policies with artemisinin-based combination therapy since 2001, active health promotion in partnership with communities living in the malaria transmission areas, and cross-border collaborations. Political commitment and long-term funding for the malaria control programme have been a critical component of the programme’s success. Breaking the cycle of transmission through strengthening of active surveillance using sensitive molecular tests and field treatment of asymptomatic persons, monitoring for antimalarial drug resistance and insecticide resistance, strengthening cross-border initiatives, and ongoing programme advocacy in the face of a significant decrease in disease burden are key priorities for achieving the elimination goal

Malaria Control in South Africa 2000–2010: Beyond MDG6

Background: Malaria is one of the key targets within Goal 6 of the Millennium Development Goals (MDGs), whereby the disease needs to be halted and reversed by the year 2015. Several other international targets have been set, however the MDGs are universally accepted, hence it is the focus of this manuscript. Methods: An assessment was undertaken to determine the progress South Africa has made against the malaria target of MDG Goal 6. Data were analyzed for the period 2000 until 2010 and verified after municipal boundary changes in some of South Africa’s districts and subsequent to verifying actual residence of malaria positive cases. Results: South Africa has made significant progress in controlling malaria transmission over the past decade; malaria cases declined by 89.41% (63663 in 2000 vs 6741 in 2010) and deaths decreased by 85.4% (453 vs 66) in the year 2000 compared to the year 2010. Coupled with this, malaria cases among children under five years of age have also declined by 93% (6791 in 2000 vs 451 in 2010). This has resulted in South Africa achieving and exceeding the malaria target of the MDGs. A series of interventions have attributed to this decrease, these include: drug policy change from monotherapy to artemisinin combination therapy, insecticide change from pyrethroids back to DDT; cross border collaboration (South Africa with Mozambique and Swaziland through the Lubombo Spatial Development Initiative– LSDI) and financial investment in malaria control. The KwaZulu-Natal Province has seen the largest reduction in malaria cases and deaths (99.1% cases- 41786 vs 380; and 98.5% deaths 340 vs 5), when comparing the year 2000 with 2010. The Limpopo Province recorded the lowest reduction in malaria cases compared to the other malaria endemic provinces (56.1% reduction- 9487 vs 4174; when comparing 2000 to 2010). Conclusions: South Africa is well positioned to move beyond the malaria target of the MDGs and progress towards elimination. However, in addition to its existing interventions, the country will need to sustain its financing for malaria control and support programmed reorientation towards elimination and scale up active surveillance coupled with treatment at the community level. Moreover cross-border malaria collaboration needs to be sustained and scaled up to prevent the re-introduction of malaria into the country

A Committee of Neural Networks for Automatic Speaker Recognition (ASR) Systems

This paper describes how the results of speaker verification systems can be improved and made robust with the use of a committee of neural networks for pattern recognition rather than the conventional single-network decision system. It illustrates the use of a supervised learning vector quantization neural network as the pattern classifier. Linear predictive coding and cepstral signal processing techniques are utilized to form hybrid feature parameter vectors to combat the effect of decreased recognition success with increased group size (number of speakers to be recognized

Speaker Identification Using a Combination of Different Parameters as Feature Inputs to an Artificial Neural Network Classifier

This paper presents a technique using artificial neural networks (ANNs) for speaker identification that results in a better success rate compared to other techniques. The technique used in this paper uses both power spectral densities (PSDs) and linear prediction coefficients (LPCs) as feature inputs to a self organizing feature map to achieve a better identification performance. Results for speaker identification with different methods are presented and compared

Shaping the evolving role of academic librarians in the fourth industrial revolution through continuous professional development at the Durban University of Technology

Due to the proliferation of disruptive technologies that drive the fourth industrial revolution (4IR), academic libraries have undergone an evolution, which has also changed the role of academic librarians. With disruptive technologies, library services can be accessed from anywhere in the world, as long as a person is connected to the Internet of Things. For academic librarians to not be left behind, they need to skill themselves to be relevant in the 4IR. It is the thesis of this study that such upskilling can be done through continuous professional development. This explanatory mixed method research used a conceptual framework to explore how the evolving role of academic librarians can be shaped through continuous professional development at the Durban University of Technology (DUT). Quantitative data was collected first through online questionnaires due to the Covid-19 pandemic, followed by qualitative data through physical interviews with selected participants. Parallel sampling was used where different samples for qualitative and quantitative study phases were drawn from the same population. For the quantitative phase, all librarians at DUT were chosen, while for the qualitative study, participants were identified and chosen purposively to the level of saturation to augment the quantitative data. The key findings suggest that the advancement of disruptive technologies has impacted and transformed the customary ways of working in the DUT library. To counter the disruption, academic librarians at DUT have embraced continuous professional development in order to update their knowledge and skills to allow them to evolve and adapt accordingly to changes within their profession. The librarians acknowledged that whilst 4IR provided many advantages, there were still many challenges, such as learning new skills and keeping abreast with new innovations especially in an environment where budget cuts are common, to overcome in respect of changes in their roles and responsibilities. Librarians acknowledged that continuous learning and development provided an advantage that allowed them to understand the evolving changes and adapt accordingly. It is concluded that librarians are perceptive and open to learning new skills to ensure that users' needs are adequately met. The infrastructure at the DUT library is in place to embrace changes, and the institution is continuing to improve the existing infrastructure to accommodate future innovations. The study suggests a framework to align librarian roles and skills with 4IR requirements. A further study on the user point of view and their current needs and how these needs are evolving with 4IR is recommended.Ph.D. (Information Science)Information Scienc

Field evaluation of a malaria rapid diagnostic test (ICT Pf)

Background. Malaria rapid diagnostic tests (MRDTs) are quickand easy to perform and useful for diagnosing malaria in primary health care settings. In South Africa most malaria infections are due to Plasmodium falciparum, and HRPII-based MRDTs have been used since 2001. Previous studies in Africa showed variability in sensitivity and specificity of HRPIIbased MRDTs; hence, we conducted a field evaluation in Limpopo province to determine the accuracy of the MRDTcurrently used in public sector clinics and hospitals.Methods. A cross-sectional observational study was conductedto determine the sensitivity and specificity of an ICT Pf MRDT. We tested 405 patients with fever with ICT Pf MRDT and compared the results with blood film microscopy (the gold standard).Results. The overall sensitivity of the ICT Pf MRDT was 99.48% (95% confidence interval (CI) 96.17 - 100%), while specificity was 96.26% (95% CI 94.7 - 100%). The positive predictive value of the test was 98.48 (99% CI 98.41 - 100%), and the negative predictive value was 99.52% (95% CI 96.47 – 100%).Conclusions. The ICT Pf MRDT is an appropriate test to use in the field in South Africa where laboratory facilities are not available. It has a high degree of sensitivity and acceptable level of specificity in accordance with the World Health Organization criteria. However, sensitivity of MRDT at low levels of parasitaemia

An evaluation of the performance and usage of ICT Pf malaria rapid diagnostic test, in the Limopo South Africa

Aim: This thesis aimed to evaluate the performance and usage of ICT Pf Malaria Rapid Diagnostic Test (MRDT), in an operational setting in the Limpopo Province, South Africa. Methods: Four studies were conducted to: assess factors affecting MRDT use (exploratory study- conducted as part of formative work); determine ICT Pf accuracy (cross-sectional study amongst 405 patients with prospective observational cohort component for follow-up); determine the performance of MRDT end-users (crosssectional observational study) and assess the suitability of using positive control antigen wells (PCWs) for routine quality control. Results: Key informants reported that MRDT accuracy, end-user proficiency and MRDT quality affect MRDT use and impact. The accuracy study found that sensitivity, specificity, positive and negative predictive values of ICT Pf test were 99.48% (99% Cl; 96.17-100.00%), 96.26% (99% Cl; 94.7-100%) 98.48 (99% Cl 98.41 -100.00%) and 96.26% (99% Cl 91.53-98.79%) respectively. Febrile patients with 'sweating' were 5 times more likely to be ICT Pf positive than those without sweating. Among the 68 patients who returned for day-seven follow up 23 (33%) were ICT Pf positive; however all were microscopy-negative. End-user proficiency: of the 15 recommended steps for MRDT use, 50% of end-users performed 11 or more steps correctly; 50% of end-users interpreted 90% of pre-prepared tests correctly. The false negative interpretation rate was 15%. The quality control study revealed that diluting PCWs with MRDT-negative blood gave better signals than diluting with citrate buffer. PCWs maintain signal strength when stored up to 30 days at 25°C at rural health clinics. Conclusions: Although ICT Pf MRDT can be used for malaria diagnosis in Limpopo, test sensitivity at low level parasitaemias in field settings need to be established. The ICT Pf test should not be used for assessing cure post-treatment. End-user proficiency needs improvement. PCWs can be used to monitor MRDT quality at PHC level

Eliminating Malaria Vectors.

Malaria vectors which predominantly feed indoors upon humans have been locally eliminated from several settings with insecticide treated nets (ITNs), indoor residual spraying or larval source management. Recent dramatic declines of An. gambiae in east Africa with imperfect ITN coverage suggest mosquito populations can rapidly collapse when forced below realistically achievable, non-zero thresholds of density and supporting resource availability. Here we explain why insecticide-based mosquito elimination strategies are feasible, desirable and can be extended to a wider variety of species by expanding the vector control arsenal to cover a broader spectrum of the resources they need to survive. The greatest advantage of eliminating mosquitoes, rather than merely controlling them, is that this precludes local selection for behavioural or physiological resistance traits. The greatest challenges are therefore to achieve high biological coverage of targeted resources rapidly enough to prevent local emergence of resistance and to then continually exclude, monitor for and respond to re-invasion from external populations

Continuing professional development opportunities in information and communication technology for academic librarians at the Durban University of Technology

Continuing Professional Development (CPD) is a vital tool for maintaining the skills and expertise of staff, especially with regard to the use of Information and Communication Technology (ICT). There is little information available about the involvement of librarians in South Africa with CPD: this study focused on academic librarians at the Durban University of Technology (DUT) Library, seeking their attitudes towards CPD and its provision. It employed a qualitative approach in its research design. Questionnaires were utilised to collect information from twenty-five academic librarians. Follow-up interviews were conducted with five respondents. The overall study indicated that, although the respondents were aware of the importance of CPD and the impact of ICT on library resources and services, not all of them kept abreast of CPD activities within their field. The respondents believed that the institutions and the professional body, the Library and Information Association of South Africa (LIASA), should work together to encourage and promote CPD activities. By encouraging CPD activities within the Library and Information Science (LIS) sector, the quality of librarianship and service delivery within the LIS would improve. Half of the respondents agreed about the importance of CPD becoming compulsory within the LIS profession and 55% of respondents considered that LIASA had a potentially important role to play in promoting CPD. However, in separate interviews, several respondents expressed doubt about the capacity of LIASA to fulfil this role.http://sajlis.journals.ac.zaam2019Information Scienc