Anatomy of a mixed-influence shelf edge delta, Karoo Basin, South Africa

The position and process regime of paralic systems relative to the shelf edge rollover is a major control on sediment transfer into deep water. The depositional strike and dip variability of an exhumed Permian shelf edge succession has been studied in the Paardeberg Ridge, Karoo Basin. Siltstone-rich slope turbidites are overlain by 25–75 m-thick prodelta parasequences. These are truncated by a 30 m-thick sandstone-prone unit of tabular or convex-topped sandstones, interpreted as wave-modified mouth bars, cut by multiple irregular concave-upwards erosive surfaces overlain by sandstones, interpreted as distributary channels. The stratigraphic context, lithofacies and architecture are consistent with a mixed-influence shelf edge delta; the erosional base to the unit marks a basinwards shift in facies, consistent with a sequence boundary. Channels become thicker, wider, more erosive and incise into deeper-water facies downdip and correlate with sandstone-rich upper slope turbidites, all of which support the bypass of sand across the rollover. The overall progradational stacking pattern results in a stratigraphic decrease in channel dimensions. The results of this study suggest a predictable relationship between channel geometry, facies and position on the shelf-to-slope profile under a mixed wave and fluvial process regime

Referral pattern and findings following planar equilibrium radionuclide angiocardiography in a tertiary hospital

Planar Equilibrium Radionuclide Angiocardiography (ERNA) is a non-invasive, reproducible and non-operator dependent Nuclear Medicine gamma camera-based technique of assessing cardiac function. Aim: To determine the common indications and findings from ERNA in a tertiary hospital in Cape Town, South Africa. Methods: The use of this database was approved by the Human Research Ethics Committee of the faculty of Health Sciences, University of Cape Town. All ERNAs conducted within a six-month period (January to June 2014), processed and reported by the authors were reviewed. The ERNAs were performed on an e.Cam dual head gamma camera (Siemens Medical Solutions, Erlangen, Germany) fitted with Low Energy High Resolution (LEHR) collimators 99m after intravenous administration of stannous pyrophosphate and Tc-pertechnetate. ECG-gated cardiac blood pool images were acquired. Images were reviewed and processed on a Siemens workstation. Cardiac morphology, size, contraction pattern, left ventricular wall motion and ejection fraction were assessed. Results: Of the 351 ERNAs of patients reviewed, 283 (80.6%) were females while 68 (19.4%) were males with a mean age of 48.3 ± 12.6 years and age range of 29 to 71 years. Indications for ERNA requests were chemotherapy 303 (86.3%), pre-operative evaluation 37 (10.5%) and ischaemic heart disease 9 (2.6%). LV size was dilated in 24 (6.8%) of the patients. Normal LV wall motion was recorded in 303 (86.3%) patients, while hypokinesia, akinesia and dyskinesia were recorded in 12.8%, 0.3% and 0.6% of the LVs respectively. Normal LVEF was recorded in 301 (85.8%) of the patients while mild, moderate and severe LV dysfunction were recorded in 12.8%, 0.8% and 0.6% of the patients respectively. Conclusion: ERNA is a frequently requested nuclear medicine examination for assessment of cardiac function in patients undergoing cardiotoxic chemotherapy

Back reaction, covariant anomaly and effective action

In the presence of back reaction, we first produce the one-loop corrections for the event horizon and Hawking temperature of the Reissner-Nordstr\"om black hole. Then, based on the covariant anomaly cancelation method and the effective action technique, the modified expressions for the fluxes of gauge current and energy momentum tensor, due to the effect of back reaction, are obtained. The results are consistent with the Hawking fluxes of a (1+1)-dimensional blackbody at the temperature with quantum corrections, thus confirming the robustness of the covariant anomaly cancelation method and the effective action technique for black holes with back reaction.Comment: 17 page

Community mobilisation with women's groups facilitated by Accredited Social Health Activists (ASHAs) to improve maternal and newborn health in underserved areas of Jharkhand and Orissa: study protocol for a cluster-randomised controlled trial

Background: Around a quarter of the world's neonatal and maternal deaths occur in India. Morbidity and mortality are highest in rural areas and among the poorest wealth quintiles. Few interventions to improve maternal and newborn health outcomes with government-mandated community health workers have been rigorously evaluated at scale in this setting.The study aims to assess the impact of a community mobilisation intervention with women's groups facilitated by ASHAs to improve maternal and newborn health outcomes among rural tribal communities of Jharkhand and Orissa.Methods/design: The study is a cluster-randomised controlled trial and will be implemented in five districts, three in Jharkhand and two in Orissa. The unit of randomisation is a rural cluster of approximately 5000 population. We identified villages within rural, tribal areas of five districts, approached them for participation in the study and enrolled them into 30 clusters, with approximately 10 ASHAs per cluster. Within each district, 6 clusters were randomly allocated to receive the community intervention or to the control group, resulting in 15 intervention and 15 control clusters. Randomisation was carried out in the presence of local stakeholders who selected the cluster numbers and allocated them to intervention or control using a pre-generated random number sequence. The intervention is a participatory learning and action cycle where ASHAs support community women's groups through a four-phase process in which they identify and prioritise local maternal and newborn health problems, implement strategies to address these and evaluate the result. The cycle is designed to fit with the ASHAs' mandate to mobilise communities for health and to complement their other tasks, including increasing institutional delivery rates and providing home visits to mothers and newborns. The trial's primary endpoint is neonatal mortality during 24 months of intervention. Additional endpoints include home care practices and health care-seeking in the antenatal, delivery and postnatal period. The impact of the intervention will be measured through a prospective surveillance system implemented by the project team, through which mothers will be interviewed around six weeks after delivery. Cost data and qualitative data are collected for cost-effectiveness and process evaluations

Harnessing the Power of Saussurea obvallata Zinc Oxide Nanoparticles for Accelerated Wound Healing and Antimicrobial Action

Adel Moalwi,1 Keerti Naik,2 Uday M Muddapur,2 Bader Aldoah,1 Hajar Hassan AlWadai,1 Abdulrahman Manaa Alamri,1 Saeed A Alsareii,1 Mater H Mahnashi,3 Ibrahim Ahmed Shaikh,4 Aejaz Abdullatif Khan,5 Sunil S More6 1Department of Surgery, College of Medicine, Najran University, Najran, Saudi Arabia; 2Department of Biotechnology, KLE Technological University, BVB Campus, Hubballi, Karnataka, India; 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; 4Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia; 5Department of General Science, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia; 6School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, Karnataka, IndiaCorrespondence: Uday M Muddapur; Mater H Mahnashi, Email [email protected]; [email protected]: Zinc oxide nanoparticles (ZnONPs) have been the subject of substantial research by virtue of their utility across extensive downstream applications. Moreover, the ZnONPs are inexpensive, reliable, and easy to produce. Green synthesis employing biological systems, particularly plant extracts, has arisen as a subject of study in nanotechnology and is gaining importance due to its multiple applications in biology, chemistry, physics, and medicine.Methods: Aqueous extract of S. obvallata was prepared and ZnONPs were synthesised using zinc acetate as a substrate. UV-Vis spectrophotometric measurement confirmed the production of ZnONPs. The ZnONPs were characterized by employing SEM, EDS, XRD, and FTIR. The ZnONPs were screened for its antimicrobial and wound healing potential.Results: The peak of absorbance for UV-Vis was observed at 370 nm. The average dimension of the particles was found to be 22.58 nm. The antibacterial activity of ZnONPs was efficient in countering a broad spectrum of bacteria and the fungi C. albicans. The results of in vitro and in vivo wound healing assays indicate that the ZnONPs possess potent wound healing potential. In the cell migration assay, the percentage of wound closure was observed to be 84.70% (p < 0.001) for ZnONPs compared to the untreated group (8.12%). In the excision wound healing rat model, the animals treated with ZnONPs and Povidone-Iodine showed a significant (p < 0.01) wound contraction in comparison to the untreated animals.Discussion: The ZnONPs promoted wound healing processes and showed promise as a therapeutic agent. However, further research is needed to understand the mechanisms of action and evaluate the long-term safety and effectiveness of ZnONPs in wound healing applications. By using renewable biological materials, the green synthesis of ZnONPs minimizes the need for synthetic reagents and lowers the total carbon footprint related to the production of nanoparticles.Keywords: green synthesis, wound healing, zinc oxide NPs, Saussurea obvallata, antimicrobia

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice

PurposeThe goal of this study was to test the hypothesis that by controlling intracellular uptake, organic cation transporter 1, Oct1 is a key determinant of the disposition and toxicity of cis-diammine(pyridine)chloroplatinum(II)(CDPCP) and oxaliplatin.MethodsPharmacokinetics, tissue accumulation and toxicity of CDPCP and oxaliplatin were compared between Oct1-/- and wild-type mice.ResultsAfter intravenous administration, hepatic and intestinal accumulation of CDPCP was 2.7-fold and 3.9-fold greater in Oct1 wild-type mice (p &lt; 0.001). Deletion of Oct1 resulted in a significantly decreased clearance (0.444 ± 0.0391 ml/min*kg versus 0.649 ± 0.0807 ml/min*kg in wild-type mice, p &lt; 0.05) and volume distribution (1.90 ± 0.161 L/kg versus 3.37 ± 0.196 L/kg in wild-type mice, p &lt; 0.001). Moreover, Oct1 deletion resulted in more severe off-target toxicities in CDPCP-treated mice. Histologic examination of the liver and measurements of liver function indicated that the level of hepatic toxicity was mild and reversible, but was more apparent in the wild-type mice. In contrast, the effect of Oct1 on the pharmacokinetics and toxicity of oxaliplatin in the mice was minimal.ConclusionsOur study suggests that Oct1 plays an important role in the pharmacokinetics, tissue distribution and toxicity of CDPCP, but not oxaliplatin

All-sky search for continuous gravitational waves from isolated neutron stars in the early O3 LIGO data

We report on an all-sky search for continuous gravitational waves in the frequency band 20-2000 Hz and with a frequency time derivative in the range of [-1.0,+0.1]×10-8 Hz/s. Such a signal could be produced by a nearby, spinning and slightly nonaxisymmetric isolated neutron star in our Galaxy. This search uses the LIGO data from the first six months of Advanced LIGO's and Advanced Virgo's third observational run, O3. No periodic gravitational wave signals are observed, and 95% confidence-level (C.L.) frequentist upper limits are placed on their strengths. The lowest upper limits on worst-case (linearly polarized) strain amplitude h0 are ∼1.7×10-25 near 200 Hz. For a circularly polarized source (most favorable orientation), the lowest upper limits are ∼6.3×10-26. These strict frequentist upper limits refer to all sky locations and the entire range of frequency derivative values. For a population-averaged ensemble of sky locations and stellar orientations, the lowest 95% C.L. upper limits on the strain amplitude are ∼1.4×10-25. These upper limits improve upon our previously published all-sky results, with the greatest improvement (factor of ∼2) seen at higher frequencies, in part because quantum squeezing has dramatically improved the detector noise level relative to the second observational run, O2. These limits are the most constraining to date over most of the parameter space searched