A refutation of the practice style hypothesis: the case of antibiotics prescription by French general practitioners for acute rhinopharyngitis

Many researches in France or abroad have highlighted the medical practice variation (MPV)phenomenon, or even the inappropriateness of certain medical decisions. There is no consensus on the origin of this MPV between preference-centred versus opportunities and constraints approaches. This study principal purpose is to refute hypothesis which assume that physicians adopt for their patient a uniform practice style for each similar clinical decision beyond the time. More specifically, multilevel models are estimated: First to measure variability of antibiotics prescription by French general practitioners for acute rhinopharyngitis, a clinical decision making context with weak uncertainty, and to tests its significance; Second to prioritize its determinants, especially those relating to GP or its practice setting environment, by controlling visit or patient confounders. The study was based on the 2001 activity data, added by an ad hoc questionnaire, of a sample of 778 GPs arising from a panel of 1006 computerized French GPs. We observe that a great part of the total variation was due to intra-physician variability (70%). Hence, in the French general practice context, we find empirical support for the rejection of the ‘practice style’, the ’enthusiasm’ or the ‘surgical signature’ hypothesis. Thus, it is patients' characteristics that largely explain the prescription, even if physicians' characteristics (area of practice, level of activity, network participation, participation in ongoing medical training) and environmental factors (recent visit from pharmaceutical sales representatives) also exert considerable influence. The latter suggest that MPV are partly caused by differences in the type of dissemination or diffusion of information. Such findings may help us to develop and identify facilitators for promoting a better use of antibiotics in France and, more generally, for influencing GPs practice when it is of interest.Medical practice variation, Multilevel analysis, Upper respiratory tract infections, Rhinopharyngitis, Antibiotics, General practitioners, Panel, France

Effect of a French Experiment of Team Work between General Practitioners and Nurses on Efficacy and Cost of Type 2 Diabetes Patients Care

This study aims to assess the efficacy and the cost of a French team work experiment between nurses and GPs for the managing of type 2 diabetes patients. Our study was based on a case control study design in which we compare the evolution of process (standard follow-up procedures) and final outcomes (glycemic control), and the evolution of cost. The study is realized for two consecutive periods between type 2 diabetes patients followed within the team work experiment (intervention group) or by "standard" GPs (controlled group). After 11 months of follow-up, we showed that patients in the intervention group, compared with those in the controlled group, have more chances to remain or to become: correctly followed-up (with OR comprise between 2.1 to 6.8, pPrimary health care, Diabetes mellitus, Health care team, Comparative study, Outcome and process assessment, Cost analysis

Soins primaires et performance : de la variabilité des pratiques des médecins généralistes au rôle de l'organisation des soins

According to economic research, the general practitioner is considered as an agent that offered information and intellectual services in health to principals. Imperfect convergence between their objectives, like the presence of uncertainties and information asymmetries, lead the physician “to fix” the quantities, the effort and the quality of the care and services delivered. Based on three articles, this thesis aims at identifying the role of the characteristics of the general practitioners and of their practice organization, on activity performance. The first articles analyzes the determinants of the antibiotic prescription for acute rhinopharyngitis variability, the second evaluates the impact of team working with nurses on the quality and the efficiency of the care for diabetic patients, and the third evaluates the impact of multi-professional group practices on the activity and the productive efficiency of GPs and on the utilization of ambulatory health care and by their patients. These researches question the relative weakness of the ambulatory health care regulation in France in terms of health care expenditure containment policies in comparison with that bearing on demand.La recherche économique considère le médecin généraliste comme un agent offrant à l’échange information et services intellectuels en santé à des principaux. L’imparfaite convergence entre leurs objectifs, comme la présence d’incertitudes et d’asymétries d’information, conduisent le médecin à « fixer » les quantités, l’effort fourni et la qualité des soins et services rendus. Cette thèse vise à identifier le rôle des caractéristiques des généralistes, de leur mode d’exercice ou d’organisation, sur la performance de leur activité, en s’appuyant sur trois articles. Le premier analyse les déterminants de la variabilité de prescription d’antibiotiques pour rhinopharyngite aiguë, le second évalue l’impact du travail en équipe avec des infirmières sur la qualité et l’efficience des soins pour les patients diabétiques, et le troisième évalue l’impact de l’exercice regroupé pluriprofessionnel sur l’activité et l’efficience productive des généralistes et l’efficience des recours aux soins ambulatoires de leurs patients. Ces travaux de recherche permettent d’interroger la faiblesse relative de la régulation de l’offre de soins ambulatoire en France en matière de politique de maîtrise de l’évolution des dépenses de santé en comparaison de celle portant sur la demande

Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial

Objectives: The aim of this study was to evaluate the effects of Lactobacilli reuteri (Prodentis) alone and in combination with scaling and root planing (SRP) in a double blind, randomized, placebo-controlled clinical trial of volunteers with chronic periodontitis. Methods: Thirty, otherwise systemically healthy, chronic periodontitis patients (19 males and 11 females, aged between 34 and 50 years) were included. The study period was 42 days. ‘Split-mouth’ design was used for the SRP, which was performed on day 0; two quadrants (either right or left) were treated with SRP whereas the remaining two quadrants were left untreated. The participants received a toothbrush, toothpaste, and brushing instructions. L. reuteri Prodentis lozenges (1×108 CFU DSM17938 + 1×108 CFU ATCC PTA 5289) or the corresponding placebo lozenges were taken twice daily from day 21 to day 42. Statistical analysis was done for comparisons of clinical parameters (Plaque Index (PI), Gingival Index (GI), Gingival Bleeding Index (GBI), probing pocket depth (PPD), clinical attachment level (CAL)) and microbiological levels of the pathogens Aggregibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi). All p-values less than 0.05 were considered significant. Assessments were made on day 0 before SRP treatment, on day 21 before administration of the lozenges, and on day 42. Results: At day 42, the PI, GI, and GBI were significantly reduced by all treatment modalities. When ranked, the amount of PI, GI and GBI reduction by the different treatments was SRP + Prodentis > Prodentis > SRP + placebo > placebo; all differences were statistically significant. For PPD and CAL, the best result was obtained with the SRP + Prodentis treatment. PPD was reduced from 5.08±0.75 to 3.78±0.61 mm (p<0.001) and CAL from 3.93±0.93 to 2.85±0.74 mm (p<0.001). Prodentis, either alone or following SRP, reduced Aa, Pi, and Pg by 1 log10 unit (p<0.01). The SRP + placebo combination did not significantly affect the levels of the pathogens. Conclusion: The present randomized controlled trial confirms the plaque inhibition, anti-inflammatory, and antimicrobial effects of L. reuteri Prodentis. L. reuteri Prodentis probiotic can be recommended during non-surgical therapy and the maintenance phase of periodontal treatment. Considering the beneficial effects of probiotics, this therapy could serve as a useful adjunct or alternative to periodontal treatment when SRP might be contraindicated. Further studies are required in this direction

Déserts médicaux en soins de premier recours : un regard économique

International audienceCet article s’intéresse à la dégradation de l’accès aux soins de premiers recours dans certains territoires et les désormais consacrés, bien que pour partie mal nommés, « déserts médicaux ». Après une présentation du contexte, nous porterons notre attention sur les déterminants des inégalités de répartition pour les médecins généralistes, puis nous nous interrogerons, à travers le prisme de la science économique, sur la pertinence des leviers de politiques publiques principalement mobilisées jusqu’à aujourd’hui en France pour répondre à ce défi, et ceux peu ou pas considérés, à l’aune de leurs effets attendus ou observés

Substitution, complémentarité et travail en équipe généralistes/infirmières : impacts potentiels du « mix des compétences »

International audienceCet article s’intéresse au contexte et aux enjeux relativement à la modification des rôles et fonctions infirmières dans le champ des soins de premier recours. Après une présentation du contexte et une synthèse de la littérature sur l’impact que l’on peut attendre de ce type de transformation, les enseignements que l’on peut tirer d’évaluation d’impact d’innovation organisationnelle dans ce domaine et mise en œuvre en France sont proposés

Primary care and performance : from medical practice variation to the role of the practice organization

La recherche économique considère le médecin généraliste comme un agent offrant à l’échange information et services intellectuels en santé à des principaux. L’imparfaite convergence entre leurs objectifs, comme la présence d’incertitudes et d’asymétries d’information, conduisent le médecin à « fixer » les quantités, l’effort fourni et la qualité des soins et services rendus. Cette thèse vise à identifier le rôle des caractéristiques des généralistes, de leur mode d’exercice ou d’organisation, sur la performance de leur activité, en s’appuyant sur trois articles. Le premier analyse les déterminants de la variabilité de prescription d’antibiotiques pour rhinopharyngite aiguë, le second évalue l’impact du travail en équipe avec des infirmières sur la qualité et l’efficience des soins pour les patients diabétiques, et le troisième évalue l’impact de l’exercice regroupé pluriprofessionnel sur l’activité et l’efficience productive des généralistes et l’efficience des recours aux soins ambulatoires de leurs patients. Ces travaux de recherche permettent d’interroger la faiblesse relative de la régulation de l’offre de soins ambulatoire en France en matière de politique de maîtrise de l’évolution des dépenses de santé en comparaison de celle portant sur la demande.According to economic research, the general practitioner is considered as an agent that offered information and intellectual services in health to principals. Imperfect convergence between their objectives, like the presence of uncertainties and information asymmetries, lead the physician “to fix” the quantities, the effort and the quality of the care and services delivered. Based on three articles, this thesis aims at identifying the role of the characteristics of the general practitioners and of their practice organization, on activity performance. The first articles analyzes the determinants of the antibiotic prescription for acute rhinopharyngitis variability, the second evaluates the impact of team working with nurses on the quality and the efficiency of the care for diabetic patients, and the third evaluates the impact of multi-professional group practices on the activity and the productive efficiency of GPs and on the utilization of ambulatory health care and by their patients. These researches question the relative weakness of the ambulatory health care regulation in France in terms of health care expenditure containment policies in comparison with that bearing on demand

Accessibilité aux soins et attractivité territoriale : proposition d’une typologie des territoires de vie français

The article presents the methodology and the results of a socio-sanitary taxonomy of French territories. This taxonomy is used to analyze primary health care in France and the effectiveness of measures to attract and retain general practitioners in underserved areas. We identify in the literature the relevant dimensions and indicators to address these issues. We made a principal component analysis (PCA) of the 32 selected indicators and then an agglomerative hierarchical clustering (AHC). We obtain 6 types of living territories which spatial distribution could be very contiguous (littoral, “empty diagonal”), more heterogeneous with departments having all type of living territories or a distribution showing an opposition between centers and peripheries