Chemical constituents of the leaves of Actinodaphne pruinosa

ABSTRACT. This study was designed to investigate the chemical constituents from Actinodaphne pruinosa growing in Malaysia. A phytochemical investigation of the leaves part resulted in the isolation of boldine (1), norboldine (2), laurotetanine (3), reticuline (4), syringaresinol (5), lupeol (6), and taraxerol (7). The structures of the isolated phytochemicals were established by analysis of their spectroscopic data, as well as the comparison with that of reported data. Notably, this is the first time to report the isolation and structural elucidation of the constituents from the leaves part of A. pruinosa.   KEY WORDS: Actinodaphne pruinosa, Aporphine, Lauraceae, Phytochemical   Bull. Chem. Soc. Ethiop. 2022, 36(4), 963-969.                                                               DOI: https://dx.doi.org/10.4314/bcse.v36i4.2

Phytochemical identification of Albertisia Papuana Becc. leaf methanolic extract through liquid chromatography tandem mass spectrometry data analysis

The leaves of Albertisia papuana Becc. (Menispermaceae) is traditionally used by the people of Borneo as rice wine’s flavor enhancer and utilized for the treatment of symptoms associated with hypertension, stroke, and cancer. Despite its potential, this plant’s part remains largely unexplored from a scientific standpoint. Thus, this work aimed to profile and identify the phytochemicals of the methanolic leaf extract of A. papuana Becc. through liquid chromatography tandem mass spectrometry-based data analysis with MZmine and global natural products social molecular networking (GNPS) platforms. The present study managed to identify a total of 21 phytochemicals from different classes of compounds including alkaloids, flavonoids, terpenoid and several other phytochemicals. Of these, three compounds (nicotiflorin 11, isorhoifolin 12, and genistein 17) are first time reported in the family meanwhile 18 compounds (5'-deoxy-5'-(methylsulfinyl) adenosine 1, coclaurine 2, magnoflorine 3 isoschaftoside 4, reticuline 5, isovitexin 6, sinapic acid 7, dicoumaroyl spermidine 8, apigenin 9, loliolide 10, liriodenine 13, moupinamide 14, paprazine 15, ferulic acid 16, n-acetylanonaine 18, 13S-Hydroxy-9Z,11E,15Z-octadecatrienoic acid 19, 2-hydroxy-3-(2-hydroxyacetoxy) propyl palmitate 20, and monoelaidin 21) are new to the genus and the species. Some of the identified phytochemicals such as moupinamide 2, apigenin 9 and magnoflorine 11 have been previously reported to exhibit biological activities related to hypertension, stroke, cancer treatment, and flavor enhancing properties of certain foods. The findings provide evidence to support the plant’s traditional uses

Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.

Background: Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrifolia L., nordamnacanthal, is a promising agent possessing several in vitro biological activities. However, the in vivo anti-tumor effects and the safety profile of nordamnacanthal are yet to be evaluated. Methods: In vitro cytotoxicity of nordamnacanthal was tested using MTT, cell cycle and Annexin V/PI assays on human MCF-7 and MDA-MB231 breast cancer cells. Mice were orally fed with nordamnacanthal daily for 28 days for oral subchronic toxicity study. Then, the in vivo anti-tumor effect was evaluated on 4T1 murine cancer cells-challenged mice. Changes of tumor size and immune parameters were evaluated on the untreated and nordamnacanthal treated mice. Results: Nordamnacanthal was found to possess cytotoxic effects on MDA-MB231, MCF-7 and 4T1 cells in vitro. Moreover, based on the cell cycle and Annexin V results, nordamnacanthal managed to induce cell death in both MDA-MB231 and MCF-7 cells. Additionally, no mortality, signs of toxicity and changes of serum liver profile were observed in nordamnacanthal treated mice in the subchronic toxicity study. Furthermore, 50 mg/kg body weight of nordamncanthal successfully delayed the progression of 4T1 tumors in Balb/C mice after 28 days of treatment. Treatment with nordamnacanthal was also able to increase tumor immunity as evidenced by the immunophenotyping of the spleen and YAC-1 cytotoxicity assays. Conclusion: Nordamnacanthal managed to inhibit the growth and induce cell death in MDA-MB231 and MCF-7 cell lines in vitro and cease the tumor progression of 4T1 cells in vivo. Overall, nordamnacanthal holds interesting anti-cancer properties that can be further explored

Treated Rhizophora mucronata tannin as a corrosion inhibitor in chloride solution

Treated Rhizopora mucronata tannin (RMT) as a corrosion inhibitor for carbon steel and copper in oil and gas facilities was investigated. Corrosion rate of carbon-steel and copper in 3wt% NaCl solution by RMT was studied using chemical (weight loss method) and spectroscopic (FTIR) techniques at various temperatures in the ranges of 26–90C. The weight loss data was compared to the electrochemical by the application of Faraday’s law for the conversion of corrosion rate data from one system to another. The inhibitive efficiency of RMT was compared with commercial inhibitor sodium benzotriazole (BTA-S). The best concentration of RMT was 20% (w/v), increase in concentration of RMT decreased the corrosion rate and increased the inhibitive efficiency. Increase in temperature increased the corrosion rate and decreased the inhibitive efficiency but, the rate of corrosion was mild with RMT. The FTIR result shows the presence of hydroxyl group, aromatic group, esters and the substituted benzene group indicating the purity of the tannin. The trend of RMT was similar to that of BTA-S, but its inhibitive efficiency for carbon-steel was poor (6%) compared to RMT (59%). BTA-S was efficient for copper (76%) compared to RMT (74%) at 40% (w/v) and 20% (w/v) concentration respectively. RMT was efficient even at low concentration therefore, the use of RMT as a cost effective and environmentally friendly corrosion inhibiting agent for carbon steel and copper is herein proposed

Advances and challenges of sand production and control in oilfields: A review

Sand production poses a critical issue in the oil and gas industry, particularly oil fields with unconsolidated sandstone reservoirs, resulting in equipment damage, wellbore instability, and heightened operational costs. The main causes of sand production include water breakthrough, unconsolidated formation, reduction in pore pressure, high production rate, gas to liquid ratio and phase change. Despite advancements in sand control methods, no single solution is universally effective for all reservoirs. Current technologies involve using advanced materials for screens, gravel packs, chemical treatment, different methods of sand prediction models, and emphasizing the integration of real-time monitoring systems to enhance sand control effectiveness. This paper discusses and analyzes the mechanisms of sand production, advanced sand management strategies, sand predictions model and monitory sensors, and challenges associated with sand control techniques, including mechanical, chemical methods, and hydrocyclone desanders. This paper highlighted some of the most used chemical agents in laboratory and field experiments for sand consolidation, are evaluated to determine their effectiveness in sand mitigation. Emphasis is placed on the limitations of existing chemical treatments and hydrocyclone desander, and the need for advanced chemical remediation techniques. Surface systems can be adjusted and maintained more easily than downhole sand control systems. Surface chemical treatment strategies such as introducing chemical sand coagulation-flocculation enhance hydrocyclone desander efficiency as new innovative sand control technology will serve as potential solutions for maintaining reservoir integrity and minimizing sand production

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Data from: Treated Rhizophora mucronata tannin as a corrosion inhibitor in chloride solution

Treated Rhizopora mucronata tannin (RMT) as a corrosion inhibitor for carbon steel and copper in oil and gas facilities was investigated. Corrosion rate of carbon-steel and copper in 3wt% NaCl solution by RMT was studied using chemical (weight loss method) and spectroscopic (FTIR) techniques at various temperatures in the ranges of 26-90ºC. The weight loss data was compared to the electrochemical by the application of Faraday's law for the conversion of corrosion rate data from one system to another. The inhibitive efficiency of RMT was compared with commercial inhibitor sodium benzotriazole (BTA-S). The best concentration of RMT was 20% (w/v), increase in concentration of RMT decreased the corrosion rate and increased the inhibitive efficiency. Increase in temperature increased the corrosion rate and decreased the inhibitive efficiency but, the rate of corrosion was mild with RMT. The FTIR result shows the presence of hydroxyl group, aromatic group, esters and the substituted benzene group indicating the purity of the tannin. The trend of RMT was similar to that of BTA-S, but its inhibitive efficiency for carbon-steel was poor (6%) compared to RMT (59%). BTA-S was efficient for copper (76%) compared to RMT (74%) at 40% (w/v) and 20% (w/v) concentration respectively. RMT was efficient even at low concentration therefore, the use of RMT as a cost effective and environmentally friendly corrosion inhibiting agent for carbon steel and copper is herein proposed

Flavonoids from the Borneo Plant Species: Eusideroxylon zwageri Teijsm. & Binn.

A new flavonoid, 7,3ˊ-dihydroxy-3,5,4ˊ-trimethoxy flavone, along with two known flavonoids, 7-hydroxy-5,4ˊ-dimethoxyflavone and 7-hydroxy-3,5,4ˊ-trimethoxy flavone were isolated from the leaves ethyl acetate extract of Eusideroxylon zwageri Teijsm. & Binn. (Lauraceae). Structures were elucidated by spectroscopic techniques such as NMR, IR, and Orbitrap Mass Spectrometry

Effect of concentration on corrosion rate and inhibitor efficiency of carbon steel specimen at room temperature (26°C).

Effect of concentration on corrosion rate and inhibitor efficiency of carbon steel specimen at room temperature (26°C).</p