Smokers and ex-smokers reaction to anti-smoking advertising : a mixed methods approach

Anti-smoking advertising is a central component of modern public health policy. Nevertheless, some smokers have reported that viewing anti-smoking advertising provokes intense nicotine craving. Anti-smoking advertising frequently features images of cigarettes and of individuals smoking. However, research indicates that images of tobacco paraphernalia may induce cravings in individuals addicted to nicotine. The effects of the presence of smoking cues in anti-smoking advertising were considered in the present study. Smokers and ex-smokers (N=63) were randomly assigned to view an anti-smoking advertisement or to complete a control task. Urge to smoke was measured pre- and post-test. Qualitative responses to anti-smoking advertising were also elicited from all participants in the intervention groups. According to both qualitative and quantitative data analyses viewing anti-smoking advertising, even with images of smoking related paraphernalia, led to decreases in craving amongst smokers. Ex-smokers experienced no change in quantitatively measured craving after viewing anti-smoking advertising. These findings are inconsistent with findings from studies using neutral or positive smoking cues. Qualitative data shows that no smokers or ex-smokers who viewed anti-smoking advertising reported an increase in tobacco craving as a result of viewing the campaign. Implications of these findings for future research and anti-smoking campaigns are discussed

From Solar and Stellar Flares to Coronal Heating: Theory and Observations of How Magnetic Reconnection Regulates Coronal Conditions

There is currently no explanation of why the corona has the temperature and density it has. We present a model which explains how the dynamics of magnetic reconnection regulates the conditions in the corona. A bifurcation in magnetic reconnection at a critical state enforces an upper bound on the coronal temperature for a given density. We present observational evidence from 107 flares in 37 sun-like stars that stellar coronae are near this critical state. The model may be important to self-organized criticality models of the solar corona.Comment: 13 pages, 2 figures, accepted to Ap. J. Lett., February 200

Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer

SRC tyrosine kinase is frequently overexpressed and activated in late-stage, poor prognosis ovarian tumours, and preclinical studies have supported the use of targeted SRC inhibitors in the treatment of this disease. The SAPPROC trial investigated the addition of the SRC inhibitor saracatinib (AZD0530) to weekly paclitaxel for the treatment of platinum resistant ovarian cancer; however, this drug combination did not provide any benefit to progression free survival (PFS) of women with platinum resistant disease. In this study we aimed to identify mechanisms of resistance to SRC inhibitors in ovarian cancer cells. Using two complementary strategies; a targeted tumour suppressor gene siRNA screen, and a phospho-receptor tyrosine kinase array, we demonstrate that activation of MAPK signalling, via a reduction in NF1 (neurofibromin) expression or overexpression of HER2 and the insulin receptor, can drive resistance to AZD0530. Knockdown of NF1 in two ovarian cancer cell lines resulted in resistance to AZD0530, and was accompanied with activated MEK and ERK signalling. We also show that silencing of HER2 and the insulin receptor can partially resensitize AZD0530 resistant cells, which was associated with decreased phosphorylation of MEK and ERK. Furthermore, we demonstrate a synergistic effect of combining SRC and MEK inhibitors in both AZD0530 sensitive and resistant cells, and that MEK inhibition is sufficient to completely resensitize AZD0530 resistant cells. This work provides a preclinical rationale for the combination of SRC and MEK inhibitors in the treatment of ovarian cancer, and also highlights the need for biomarker driven patient selection for clinical trials

The theoretical instability strip of M dwarf stars

The overstability of the fundamental radial mode in M dwarf models was theoretically predicted by Rodr\'iguez-L\'opez et al. (2012). The periods were found to be in the ranges ~25-40 min and ~4-8 h, depending on stellar age and excitation mechanism. We have extended our initial M dwarf model grid in mass, metallicity, and mixing length parameter. We have also considered models with boundary conditions from PHOENIX NextGen atmospheres to test their influence on the pulsation spectra. We find instability of non-radial modes with radial orders up to k=3, degree l=0-3, including p and g modes, with the period range extending from 20 min up to 11 h. Furthermore, we find theoretical evidence of the potential of M dwarfs as solar-like oscillators.Comment: 11 pages, 7 figures, 3 tables + 3 appendix tables; accepted for publication in MNRAS (December 3, 2013

Making automation pay - cost & throughput trade-offs in the manufacture of large composite components

The automation of complex manufacturing operations can provide significant savings over manual processes, and there remains much scope for increasing automation in the production of large scale structural composites. However the relationships between driving variables are complex, and the achievable throughput rate and corresponding cost for a given design are often not apparent. The deposition rate, number of machines required and unit production rates needed are interrelated and consequently the optimum unit cost is difficult to predict. A detailed study of the costs involved for a series of composite wing cover panels with different manufacturing requirements was undertaken. Panels were sized to account for manufacturing requirements and structural load requirements allowing both manual and automated lay-up procedures to influence design. It was discovered that the introduction of automated tape lay-up can significantly reduce material unit cost, and improve material utilisation, however higher production rates are needed to see this benefit

Efficacy of alternative seating on attention, in-seat behavior, and occupational performance in children with Attention Deficit Hyperactivity Disorder

Currently, there is one systematic review conducted by Gochenour and Poskey7 that synthesize current research evidence regarding alternative seating for students with attention difficulties. A limitation of this review, as noted by the authors, is a lack of a consistent definition of attention difficulty in the studies they included. A systematic review focused on a specific, well-defined diagnosis will better contribute to practice recommendations since these recommendations will be tailored to a clear and comprehensive understanding of the child’s attentional and occupational challenges. The review also included studies of children with autism spectrum disorder (ASD).7 While those with ASD may also have difficulties with attention, in-seat behavior and occupational performance, the underlying mechanism yielding these symptoms may be different than in children with ADHD. Thus, alternative seating may not work in the same way for children with ASD as it would for children with ADHD.7 Thus, a systematic review is needed to examine the evidence from all current studies regarding alternative seating on improving attention, in-seat behavior and occupational performance in students with ADHD to increase evidence-based practice in the field of occupational therapy

Mapping warm molecular hydrogen with Spitzer's Infrared Array Camera (IRAC)

Photometric maps, obtained with Spitzer's Infrared Array Camera (IRAC), can provide a valuable probe of warm molecular hydrogen within the interstellar medium. IRAC maps of the supernova remnant IC443, extracted from the Spitzer archive, are strikingly similar to spectral line maps of the H2 pure rotational transitions that we obtained with the Infrared Spectrograph (IRS) instrument on Spitzer. IRS spectroscopy indicates that IRAC Bands 3 and 4 are indeed dominated by the H2 v=0-0 S(5) and S(7) transitions, respectively. Modeling of the H2 excitation suggests that Bands 1 and 2 are dominated by H2 v=1-0 O(5) and v=0-0 S(9). Large maps of the H2 emission in IC433, obtained with IRAC, show band ratios that are inconsistent with the presence of gas at a single temperature. The relative strengths of IRAC Bands 2, 3, and 4 are consistent with pure H2 emission from shocked material with a power-law distribution of gas temperatures. CO vibrational emissions do not contribute significantly to the observed Band 2 intensity. Assuming that the column density of H2 at temperatures T to T+dT is proportional to T raised to the power -b for temperatures up to 4000 K, we obtained a typical estimate of 4.5 for b. The power-law index, b, shows variations over the range 3 to 6 within the set of different sight-lines probed by the maps, with the majority of sight-lines showing b in the range 4 to 5. The observed power-law index is consistent with the predictions of simple models for paraboloidal bow shocks.Comment: 27 pages, including 11 figures. Accepted for publication in Ap

Deliberate Apprenticeship in the Pediatric Emergency Department Improves Experience for Third-year Students

INTRODUCTION: The Pediatric Emergency Department (PED) provides medical students with learning in a high-volume, fast-paced environment; characteristics that can be stressful for new students. Shadowing can improve transitioning, yet this alone does not facilitate students’ development of independent medical care competencies. This study evaluates if third-year medical students’ deliberate apprenticeship with senior residents increases students’ comfort and patient exposure in the PED. METHODS: This study took place over the 2011-2012 academic year, and study participants were all third-year medical students during their pediatric clerkship rotation. This was a prospective educational intervention assigning students to randomized control blocks of deliberate apprenticeship (DA) intervention or control. DA students were paired with a senior resident who oriented and worked with the student, while control students were unpaired. All students completed a 20-question structured survey at shift end, which included questions about their perception of the learning environment, comfort with, and number of patient care responsibilities performed. We used independent Mann-Whitney and t-tests to compare experiences between the groups. Statistical significance was defined as p<0.05. We used the constant comparative method to qualitatively analyze students’ comments. RESULTS: Response rate was 85% (145/169). Students also rated on 5-point Likert-scale their level of comfort with defined aspects of working in the PED. DA students (n=76) were significantly more comfortable obtaining histories (4.2 versus 3.8) and formulating differential diagnoses (3.9 versus 3.4). DA students also performed more physical exams (2.9 versus 2.4). We categorized themes from the qualitative analysis of the students’ comments about their PED experience. The titles for these themes are as follows: PED provides a good learning experience; uncertainty about the medical student’s role in the PED; third-year medical students compete with other learners for teaching attention; opportunities provided to medical students for inclusion in patient care; personal knowledge deficits limit the ability to participate in the PED; PED pace affects learning opportunities. CONCLUSION: DA constitutes a feasible approach to the clinical learning environment that increases students’ patient care experiences and may ease transitioning for undergraduate medical students to new clinical environments

'The world is full of big bad wolves': investigating the experimental therapeutic spaces of R.D. Laing and Aaron Esterson

In conjunction with the recent critical assessments of the life and work of R.D. Laing, this paper seeks to demonstrate what is revealed when Laing’s work on families and created spaces of mental health care are examined through a geographical lens. The paper begins with an exploration of Laing’s time at the Tavistock Clinic in London during the 1960s, and of the co-authored text with Aaron Esterson entitled, Sanity, Madness and the Family (1964). The study then seeks to demonstrate the importance Laing and his colleague placed on the time-space situatedness of patients and their worlds. Finally, an account is provided of Laing’s and Esterson’s spatial thinking in relation to their creation of both real and imagined spaces of therapeutic care