Vessel tractography using an intensity based tensor model with branch detection

In this paper, we present a tubular structure seg- mentation method that utilizes a second order tensor constructed from directional intensity measurements, which is inspired from diffusion tensor image (DTI) modeling. The constructed anisotropic tensor which is fit inside a vessel drives the segmen- tation analogously to a tractography approach in DTI. Our model is initialized at a single seed point and is capable of capturing whole vessel trees by an automatic branch detection algorithm developed in the same framework. The centerline of the vessel as well as its thickness is extracted. Performance results within the Rotterdam Coronary Artery Algorithm Evaluation framework are provided for comparison with existing techniques. 96.4% average overlap with ground truth delineated by experts is obtained in addition to other measures reported in the paper. Moreover, we demonstrate further quantitative results over synthetic vascular datasets, and we provide quantitative experiments for branch detection on patient Computed Tomography Angiography (CTA) volumes, as well as qualitative evaluations on the same CTA datasets, from visual scores by a cardiologist expert

Vessel tractography using an intensity based tensor model

In this paper, we propose a novel tubular structure segmen- tation method, which is based on an intensity-based tensor that fits to a vessel. Our model is initialized with a single seed point and it is ca- pable of capturing whole vessel tree by an automatic branch detection algorithm. The centerline of the vessel as well as its thickness is extracted. We demonstrated the performance of our algorithm on 3 complex contrast varying tubular structured synthetic datasets for quantitative validation. Additionally, extracted arteries from 10 CTA (Computed Tomography An- giography) volumes are qualitatively evaluated by a cardiologist expert’s visual scores

Prothrombin Complex Concentrates in Life-Threatening Bleeding

[Abtract Not Available

An Analysis of the Impact of the Syrian Crisis on Turkey’s Politic-Military, Social and Economic Security

This study analyzes how the ongoing Syrian Crisis has affected Turkey’s security. It starts with an overview of recent developments in the Middle East in general and in Syria specifically. It then examines the political, military, social, and economic effects of the Syrian Crisis for Turkey’s security. It concludes that the Syrian Crisis represents Turkey’s most challenging security problem since the end of the Second World War as it has had many profound impacts on the country

Genetic Diagnosis of Hereditary Hemorrhagic Telangiectasia: Four Novel Pathogenic Variations in Turkish Patients

Aims: Hereditary hemorrhagic telangiectasia is an autosomal dominant disorder characterized by telangiectasia, epistaxis, and vascular malformations. Pathogenic mutations were found in ENG, AVCRL1, SMAD4, and GDF genes. In this study, we present our database of patients with hereditary hemorrhagic telangiectasia regarding the phenotype-genotype relations and discuss two novel ENG gene pathogenic variations in two unrelated families. Methods: Next Generation Sequencing analysis was performed on the peripheral blood of nine patients with hereditary hemorrhagic telangiectasia in four unrelated families. All patients were diagnosed with hereditary hemorrhagic telangiectasia according to the Curaçao criteria. Data on treatment and screenings of visceral involvement were recorded from files. Results: We have found a pathogenic variation in either the ENG or ACVRL1 gene in each family. Two novel pathogenic variations in the ENG gene, including NM_000118.3 (ENG): c.416delC (p.P139fs*24) and NM_000118.3(ENG): c.1139dupT (p.Leu380PhefsTer16), were found in the same family. The NM_000020.2(ACVRL1): c.1298C>T (p.Pro433Leu) pathogenic variation in the ACVRL1 gene in our first family and a novel heterozygous likely pathogenic NM_000020.2(ACVRL1): c.95T>C (p.Val32Ala) variation was found in our second family. Seven of the nine patients were treated with thalidomide for controlling bleeding episodes. All patients responded to thalidomide. In one patient, the response to thalidomide was lost and switched to bevacizumab. Conclusion: In hereditary hemorrhagic telangiectasia, certain types of mutations correlate with disease phenotypes and with next generation sequencing methods. New pathogenic variations can be revealed, which might help manage patients with hereditary hemorrhagic telangiectasi

İLKOKUL KADEMESİNDE YAPILMIŞ ARTIRILMIŞ GERÇEKLİK ÇALIŞMALARININ İNCELENMESİ

Son yıllarda büyük bir ivme kazanan artırılmış gerçeklik teknolojisinin eğitimde kullanımıyla ilgili çalışmaların çoğaldığı görülmektedir. Bu araştırma ile, 2012-2022 yılları arasında ilkokul kademesinde artırılmış gerçeklik teknolojisinin kullanımını konu alan tez ve makalelerin belirlenen ölçütler doğrultusunda nasıl bir dağılım gösterdiğini belirlemek amaçlanmıştır. Bu amaca yönelik olarak YÖK Ulusal Tez Merkezi, TR Dizin ve DergiPark’ta yapılan tarama sonucunda 11 tez ve 3 makale araştırmaya dahil edilmiştir. Bu doğrultuda belirlenen çalışmalar Excel programında hazırlanan “Tez/Makale İnceleme Formu” ile yayın yılı, yayın türü, sınıf düzeyi, ders, katılımcı sayısı, kullanılan yöntem, veri toplama aracı, elde edilen bulgular ve sonuçlar kategorilerine göre incelenmiştir. Buna göre en fazla sayıda araştırmanın 2022 ve 2019 yıllarında yapıldığı, en çok çalışmanın da yüksek lisans tezi olarak yer aldığı görülmüştür. Sınıf düzeyine bakıldığında en çok 4. sınıflarla çalışma yapıldığı ve Türkçe dersine yönelik araştırmaların çoğunlukta olduğu tespit edilmiştir. Katılımcı sayıları bakımından 1-30 katılımcılı çalışmaların sayıca fazla olduğu belirlenmiştir. Nicel ve karma çalışmaların nitel çalışmalardan daha fazla tercih edildiği görülmüştür. Ayrıca artırılmış gerçeklik teknolojisinin en çok akademik başarıya etkisinin incelendiği, ölçek olarak en çok öntest-sontest kullanıldığı da yine bulgular arasındadır. Bunlarla birlikte ilkokul kademesine yönelik artırılmış gerçeklik teknolojisinin yer aldığı çok az sayıda çalışma yapıldığı, matematik konularına yeterince yer verilmediği ve ilkokulun ilk yıllarında somut işlem dönemindeki öğrencilerle neredeyse hiç çalışma yapılmadığı ulaşılan sonuçlar arasındadır. Bu sonuçlar göz önünde bulundurularak ileride yapılacak çalışmalar için çeşitli önerilerde bulunulmuştur

Drug Induced Thrombotic Microangiopathy with Certolizumab Pegol

Background: Certolizumab pegol is used to treat ankylosing spondylitis, Crohn’s disease, psoriatic arthritis, and rheumatoid arthritis. Unlike other monoclonal antibodies such as infliximab and adalimumab, certolizumab does not contain an Fc fraction and hence does not induce complement activation. In this report, we describe the case of a patient with thrombotic microangiopathy caused due to certolizumab pegol, with a brief description about the pathophysiological approach to thrombotic microangiopathy. Case Report: A-39-year-old man suffering from ankylosing spondylitis for the past 10 years presented with fatigue. He had been on certolizumab pegol treatment for 6 months, starting with 400 and 200 mg every 2 weeks. He had significant nonimmune hemolytic anemia and thrombocytopenia without a disseminated intravascular coagulopathy. Schistocytes were observed in more than 10% of the erythrocytes per field. Plasma exchange along with corticosteroid treatment was started. There was a dramatic improvement within a week, and after 10 sessions of plasma exchange, the patient was discharged on corticosteroids with a tapering plan. ADAMTS13 enzyme activity was determined to be normal. Conclusion: The development of drug-induced thrombotic microangiopathy may be either immune-mediated or dose-dependent toxicity-mediated Anti-drug antibodies and their immunological aspects are still unclear and yet to be elucidated