Upregulation of intrarenal angiotensinogen in diabetes

Universidade Federal de São Paulo, Dept Med, Div Nephrol, BR-04023040 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Nephrol, BR-04023040 São Paulo, BrazilWeb of Scienc

Performing the Egyptian revolution : origins of collective restraint action in the Midan

This research was supported by a Carnegie Trust for the Universities of Scotland grant.In January/February 2011, the world watched with admiration the Egyptian revolution that toppled President Housni Mubarak. The demonstration in Midan al-Tahrir (Liberation Square in central Cairo), which was the nucleus of the revolution, highlighted a largely spontaneous, civil and peaceful political performance. However, this performance was temporary, contradicting subsequent bloody conflicts in post-revolutionary Egypt. This article examines the socio-political origins of the Midan performance. It argues that the demonstrators exercised collective restraint, which was temporary but necessary, in order to topple Mubarak. Building on Norbert Elias’ civilising process theory and social movements literature, it is argued that the origins of this performance are found in a collective knowledge of regime strategy and narrative, Egyptian socio-political values and existing repertoires of contention. Drawing on primary sources and semi-structured interviews, the article contends that the demonstrators exercised collective restraint to reframe regime narrative and draw public support for the revolution.PostprintPeer reviewe

Enhancing similarity distances using mandatory and optional forearly fault detection

Software Product Line (SPL) describes procedures, techniques, and tools in software engineering by using a common method of production for producing a group of software systems that identical from a shared set of software assets. In SPL, the similarity-based prioritization can resemble combinatorial interaction testing in scalable and efficient way by choosing and prioritize configurations that most dissimilar. However, the similarity distances in SPL still not so much cover the basic detail of feature models which are the notations. Plus, the configurations always have been prioritized based on domain knowledge but not much attention has been paid to feature model notations. In this paper, we proposed the usage of mandatory and optional notations for similarity distances. The objective is to improve the average percentage of faults detected (APFD). We investigate four different distances and make modifications on the distances to increase APFD value. These modifications are the inclusion of mandatory and optional notations with the similarity distances. The results are the APFD values for all the similarity distances including the original and modified similarity distances. Overall, the results shown that by subtracting the optional notation value can increase the APFD by 3.71% from the original similarity distance

Comparative antibacterial potential of selected aldehyde-based biocides and surfactants against planktonic Pseudomonas fluorescens

The antimicrobial efficacy of two aldehydebased biocides (glutaraldehyde, GTA, and orthophthalaldehyde, OPA) and two surfactants (cetyltrimethyl ammonium bromide, CTAB, and sodium dodecyl sulphate, SDS) was tested against planktonic Pseudomonas fluorescens. The antimicrobial effects were evaluated by respiratory activity as a measure of the oxygen uptake rate, adenosine triphosphate (ATP) release, outer membrane proteins (OMP) expression and cellular colour changes. The results were compared with the bacterial characteristics without chemical treatment. Tests in the presence of bovine serum albumin (BSA), in order to mimic a disinfection process in the real situation under dirty conditions, were performed according to the European Standard EN-1276. P. fluorescens was completely inactivated with OPA (minimum bactericidal concentration, MBC = 0.5 mM) and CTAB (MBC = 5 mM) and was resistant to GTA and SDS. Only CTAB promoted cellular disruption and consequent ATP release. The antimicrobial action of the chemicals tested was significantly reduced when BSA was introduced into the bacterial cultures, increasing markedly the MBC values. Additionally, the presence of BSA acted as a disruption protective agent when CTAB was applied and stimulated the bacterial respiratory activity when lower concentrations of SDS were tested. The OMP of the bacterial cells was affected by the application of both surfactants. OMP expression remained unaltered after biocide treatment. Bacterial colour change was noticed after treatment with biocides and surfactants. In summary, P. fluorescens was extremely resistant to GTA and SDS, with antimicrobial action being quenched markedly by the reaction with BSA.Instituto de Biotecnologia e Química Fina (IBQF).Fundação para a Ciência e a Tecnologia (FCT) - (Project CHEMBIO - POCI/BIO/61872/2004

Endoscopic Retrograde Cholangiopancreatography at Henry Ford Hospital: 1972-1977

Between 7972 and /977, 440 patients underwent endoscopic retrograde cholangiopancreatography (FRCP) at Henry Ford Hospital. The procedure was found to be most useful for identifying the site and nature of an extrahepatic obstruction, the diagnosis of pancreatic cancer, and the preoperative evaluation of chronic pancreatitis. One death occurred as a result of cholangitis in a patient with cancer of the pancreas. Review of the data has led us to refine our indications for FRCP. It has been shown to be a valuable technique with a low incidence of complications in evaluating pancreaticobiliary disease. Based on our study, it would be indicated for jaundiced patients without dilated ducts by echogram or with failure of or contraindication to percutaneous transhepatic cholangiography (PTC), carefully selected patients with unexplained abdominal pain, preoperative evaluation of patients with chronic pancreatitis, and in patients with presumed primary biliary cirrhosis

The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task

Attentional processing deficits are a core feature of schizophrenia, likely contributing to the persistent functional and occupational disability observed in patients with schizophrenia. The pathophysiology of schizophrenia is hypothesized to involve dysregulation of NMDA receptor-mediated glutamate transmission, contributing to disruptions in normal dopamine transmission. Preclinical investigations often use NMDA receptor antagonists, such as phencyclidine (PCP), to induce cognitive disruptions relevant to schizophrenia. We sought to test the ability of partial dopamine D-2/D-3 agonists, cariprazine and aripiprazole, to attenuate PCP-induced deficits in attentional performance. The objective of this study is to determine whether systemic administration of cariprazine or aripiprazole attenuated 5-choice serial reaction time task (5-CSRTT) deficits induced by repeated exposure to PCP. We utilized a repeated PCP-treatment regimen (2 mg/kg, subcutaneous [s.c.], once daily for 5 days) in rats to induce deficits in the 5-CSRTT. Rats were pre-treated with cariprazine (0.03, 0.1, or 0.3 mg/kg, oral [p.o.]) or aripiprazole (1, 3, or 10 mg/kg, p.o.) to determine whether they prevented PCP-induced deficits in the 5-CSRTT performance. PCP treatment increased inappropriate responding in the 5-CSRTT, elevating incorrect, premature, and timeout responses. Cariprazine treatment reduced PCP-induced increases in inappropriate responding. However, at higher doses, cariprazine produced non-specific response suppression, confounding interpretation of the attenuated PCP-induced deficits. Aripiprazole treatment also attenuated PCP-induced deficits; however, unlike cariprazine treatment, aripiprazole reduced correct responding and increased omissions. Cariprazine and aripiprazole both demonstrated potential in attenuating PCP-induced deficits in the 5-CSRTT performance. While both compounds produced non-specific response suppression, these effects were absent when 0.03 mg/kg cariprazine was administered

Test case prioritization approaches in regression testing: A systematic literature review

Context Software quality can be assured by going through software testing process. However, software testing phase is an expensive process as it consumes a longer time. By scheduling test cases execution order through a prioritization approach, software testing efficiency can be improved especially during regression testing. Objective It is a notable step to be taken in constructing important software testing environment so that a system's commercial value can increase. The main idea of this review is to examine and classify the current test case prioritization approaches based on the articulated research questions. Method Set of search keywords with appropriate repositories were utilized to extract most important studies that fulfill all the criteria defined and classified under journal, conference paper, symposiums and workshops categories. 69 primary studies were nominated from the review strategy. Results There were 40 journal articles, 21 conference papers, three workshop articles, and five symposium articles collected from the primary studies. As for the result, it can be said that TCP approaches are still broadly open for improvements. Each approach in TCP has specified potential values, advantages, and limitation. Additionally, we found that variations in the starting point of TCP process among the approaches provide a different timeline and benefit to project manager to choose which approaches suite with the project schedule and available resources. Conclusion Test case prioritization has already been considerably discussed in the software testing domain. However, it is commonly learned that there are quite a number of existing prioritization techniques that can still be improved especially in data used and execution process for each approach

Adopting the Appropriate Performance Measures for Soft Computing-based Estimation by Analogy

Soft Computing based estimation by analogy is a lucrative research domain for the software engineering research community. There are a considerable number of models proposed in this research area. Therefore, researchers are of interest to compare the models to identify the best one for software development effort estimation. This research showed that most of the studies used mean magnitude of relative error (MMRE) and percentage of prediction (PRED) for the comparison of their estimation models. Still, it was also found in this study that there are quite a number of criticisms done on accuracy statistics like MMRE and PRED by renowned authors. It was found that MMRE is an unbalanced, biased, and inappropriate performance measure for identifying the best among competing estimation models. The accuracy statistics, e.g., MMRE and PRED, are still adopted in the evaluation criteria by the domain researchers, stating the reason for “widely used,” which is not a valid reason. This research study identified that, since there is no practical solution provided so far, which could replace MMRE and PRED, the researchers are adopting these measures. The approach of partitioning the large dataset into subsamples was tried in this paper using estimation by analogy (EBA) model. One small and one large dataset were considered for it, such as Desharnais and ISBSG release 11. The ISBSG dataset is a large dataset concerning Desharnais. The ISBSG dataset was partitioned into subsamples. The results suggested that when the large datasets are partitioned, the MMRE produces the same or nearly the same results, which it produces for the small dataset. It is observed that the MMRE can be trusted as a performance metric if the large datasets are partitioned into subsamples

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity

Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry. The study aims to compare the effects of cariprazine and aripiprazole on PCP-induced changes in the extracellular levels of glutamate, dopamine, serotonin, noradrenaline, and GABA in the rat medial prefrontal cortex (mPFC), and on locomotor activation. Microdialysis was performed in awake rats with probes placed into the mPFC. Rats (n = 7/group) received vehicle (saline), cariprazine (0.05, 0.2, or 0.8 mg/kg), or aripiprazole (3 or 20 mg/kg) via gavage. After 60 min, 5 mg/kg PCP was administered intraperitoneally (i.p.). Samples were taken before drug administration, during pretreatment, and after PCP injection. Locomotor activity recording and microdialysis sampling occurred simultaneously. PCP treatment increased extracellular levels of all the neurotransmitters tested except GABA, for which there were no significant changes. Cariprazine and aripiprazole dose-dependently inhibited the PCP-induced increases of tested neurotransmitters. Overall effects were significant for higher cariprazine doses and both aripiprazole doses for glutamate and noradrenaline, for higher cariprazine doses and 20 mg/kg aripiprazole for dopamine, and for 0.8 mg/kg cariprazine and 20 mg/kg aripiprazole for serotonin and locomotor activity. Both cariprazine and aripiprazole dose-dependently attenuated PCP-induced hyperlocomotion and acute increases in glutamate, dopamine, noradrenaline, and serotonin levels in the mPFC; cariprazine was approximately 5-fold more potent than aripiprazole

Strategy for scalable scenarios modeling and calculation in early software reliability engineering

System scenarios derived from requirements specification play an important role in the early software reliability engineering. A great deal of research effort has been devoted to predict reliability of a system at early design stages. The existing approaches are unable to handle scalability and calculation of scenarios reliability for large systems. This paper proposes modeling of scenarios in a scalable way by using a scenario language that describes system scenarios in a compact and concise manner which can results in a reduced number of scenarios. Furthermore, it proposes a calculation strategy to achieve better traceability of scenarios, and avoid computational complexity. The scenarios are pragmatically modeled and translated to finite state machines, where each state machine represents the behaviour of component instance within the scenario. The probability of failure of each component exhibited in the scenario is calculated separately based on the finite state machines. Finally, the reliability of the whole scenario is calculated based on the components’ behaviour models and their failure information using modified mathematical formula. In this paper, an example related to a case study of an automated railcar system is used to verify and validate the proposed strategy for scalability of system modeling