Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles

A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylategroups, on the external surface using a range of conjugation strategies. The multiple, organometallic, redox-active ferrocene moieties on the outer surface of the virus are electrochemically independent with reduction potentials that span a potential window of 0.16 V that are dependent on the site of modification and the nature of the ferrocene derivative. The number of ferrocenes coupled to each virus ranges from about 100 to 240 depending upon the conjugation site and the linker length and these redox active units can provide multielectron reservoirs

Two and three-dimensional oscillons in nonlinear Faraday resonance

We study 2D and 3D localised oscillating patterns in a simple model system exhibiting nonlinear Faraday resonance. The corresponding amplitude equation is shown to have exact soliton solutions which are found to be always unstable in 3D. On the contrary, the 2D solitons are shown to be stable in a certain parameter range; hence the damping and parametric driving are capable of suppressing the nonlinear blowup and dispersive decay of solitons in two dimensions. The negative feedback loop occurs via the enslaving of the soliton's phase, coupled to the driver, to its amplitude and width.Comment: 4 pages; 1 figur

Towards functional safety in automotive electronics

International audienceThe part of electronics in automobile design becomes more and more important with an exponential growth during the last 10 years. Nowadays, innovation in automotive industry is driven by electronics. New upcoming electrical/electronic systems (E/E systems) such as advanced driver assistance systems or x-by-wire systems as well as consumer expectation regarding safety will require a dedicated standard to ensure design, development and production of safe products before their introduction on the market.ISO/TC22/SC3/WG16 has been formed to issue the ISO26262 international standard that will specifically address functional safety of E/E systems of automotive industry.This paper provides information about the future ISO26262 which is based on the current results of ISO/TC22/SC3/WG16 [1], those still being subject to changes before the international standard release

Toward the application of ISO 26262 for real-life embedded mechatronic systems

International audienceThe document ISO 26262 entitled ‘Road vehicles – Functional Safety’ [1] is a standard being issued by the TC22/SC3/WG16 working group of the International Standard Organization. Its scope is the functional safety of electric and electronic (E/E) embedded systems installed in automotive vehicles

Practical computational toolkits for dendrimers and dendrons structure design

Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures. Herein we describe two novel graphical user interface (GUI) toolkits written in Python that provide an improved degree of automation for rapid assembly of dendrimers and generation of their 2D and 3D structures. Our first toolkit uses the RDkit library, SMILES nomenclature of monomers and SMARTS reaction nomenclature to generate SMILES and mol files of dendrimers without 3D coordinates. These files are used for simple graphical representations and storing their structures in databases. The second toolkit assembles complex topology dendrimers from monomers to construct 3D dendrimer structures to be used as starting points for simulation using existing and widely available software and force fields. Both tools were validated for ease-of-use to prototype dendrimer structure and the second toolkit was especially relevant for dendrimers of high complexity and size.Peer reviewe

Low mass dimuon production in proton and ion induced interactions at SPS

The low mass dimuon spectra collected in p-U collisions by the NA38 experiment significantly exceeds the total cross section expected from previous analysis, done by other experiments. The `excess' events have a harder \pt\ distribution than the muon pairs from $\eta$ and $\omega$ Dalitz decays, expected to dominate the mass window 0.4--0.65~GeV/$c^2$. We conjecture that the excess events might be due to \qqbar\ annihilations, negligible at low \pt\ but made visible by the \mt\ cut applied in the NA38 data. Taking this assumption to parametrise the p-U spectra, we proceed with the analysis of the S-Cu, S-U and Pb-Pb data, collected by the NA38 and NA50 experiments, where we find that the measured mass spectra does not seem to exceed the expected low mass `cocktail' by more than 20\,\%

Anomalous J/ψJ/\psi suppression in Pb-Pb interactions at 158 GeV per nucleon

The Drell-Yan and J/psi cross-sections measured in Pb-Pb collisions are compared with the values extrapolated from the results obtained in proton and light ion induced reactions. While the Drell-Yan production exhibits the normal expected behaviour, the yield of J/psi in Pb-Pb interactions is abnormally low, as it lies 9 standard deviations below the expected value. Moreover, the departure from the expected behaviour increases significantly from peripheral to central collisions. (C) 1997 Elsevier Science B.V