Phase-conjugate optical coherence tomography

Quantum optical coherence tomography (Q-OCT) offers a factor-of-two improvement in axial resolution and the advantage of even-order dispersion cancellation when it is compared to conventional OCT (C-OCT). These features have been ascribed to the non-classical nature of the biphoton state employed in the former, as opposed to the classical state used in the latter. Phase-conjugate OCT (PC-OCT), introduced here, shows that non-classical light is not necessary to reap Q-OCT's advantages. PC-OCT uses classical-state signal and reference beams, which have a phase-sensitive cross-correlation, together with phase conjugation to achieve the axial resolution and even-order dispersion cancellation of Q-OCT with a signal-to-noise ratio that can be comparable to that of C-OCT.Comment: 4 pages, 3 figure

Duals of noncommutative supersymmetric U(1) gauge theory

Parent actions for component fields are utilized to derive the dual of supersymmetric U(1) gauge theory in 4 dimensions. Generalization of the Seiberg-Witten map to the component fields of noncommutative supersymmetric U(1) gauge theory is analyzed. Through this transformation we proposed parent actions for noncommutative supersymmetric U(1) gauge theory as generalization of the ordinary case.Duals of noncommutative supersymmetric U(1) gauge theory are obtained. Duality symmetry under the interchange of fields with duals accompanied by the replacement of the noncommutativity parameter \Theta_{\mu\nu} with \tilde{\Theta}_{\mu \nu} = \epsilon_{\mu\nu\rho\sigma}\Theta^{\rho\sigma} of the non--supersymmetric case is broken at the level of actions. We proposed a noncommutative parent action for the component fields which generates actions possessing this duality symmetry.Comment: Typos corrected. Version which will appear in JHE

Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement

<div><p>Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients with primary or secondary antibody deficiencies on immunoglobulin (Ig)-replacement treatment. The demographics, causes of immunodeficiency, diagnostic delay, clinical and laboratory features, and infection frequency were analysed retrospectively. Chemotherapy for B cell lymphoma and the use of Rituximab, corticosteroids or immunosuppressive medications were the most common causes of secondary antibody deficiency in this cohort. There was no difference in diagnostic delay or bronchiectasis between primary and secondary antibody deficiency patients, and both groups experienced disorders associated with immune dysregulation. Secondary antibody deficiency patients had similar baseline levels of serum IgG, but higher IgM and IgA, and a higher frequency of switched memory B cells than primary antibody deficiency patients. Serious and non-serious infections before and after Ig-replacement were also compared in both groups. Although secondary antibody deficiency patients had more serious infections before initiation of Ig-replacement, treatment resulted in a significant reduction of serious and non-serious infections in both primary and secondary antibody deficiency patients. Patients with secondary antibody deficiency experience similar delays in diagnosis as primary antibody deficiency patients and can also benefit from immunoglobulin-replacement treatment.</p></div

Complex cytogenetic rearrangements at the DURS1 locus in syndromic Duane retraction syndrome

Key Clinical Message A patient with syndromic Duane retraction syndrome harbors a chromosome 811.1q13.2 inversion and 8p11.1-q12.3 marker chromosome containing subregions with differing mosaicism and allele frequencies. This case highlights the potential requirement for multiple genetic methods to gain insight into genotype–phenotype correlation, and ultimately into molecular mechanisms that underlie human disease

Renewing Criminalized and Hegemonic Cultural Landscapes

The Mafia's long historical pedigree in Mezzogiorno, Southern Italy, has empowered the Mafioso as a notorious, uncontested, and hegemonic figure. The counter-cultural resistance against the mafiosi culture began to be institutionalized in the early 1990s. Today, Libera Terra is the largest civil society organization in the country that uses the lands confiscated from the Mafia as a space of cultural repertoire to realize its ideals. Deploying labor force through volunteer participation, producing biological fruits and vegetables, and providing information to the students on the fields are the principal cultural practices of this struggle. The confiscated lands make the Italian experience of anti-Mafia resistance a unique example by connecting the land with the ideals of cultural change. The sociocultural resistance of Libera Terra conveys a political message through these practices and utters that the Mafia is not invincible. This study draws the complex panorama of the Mafia and anti-Mafia movement that uses the ‘confiscated lands’ as cultural and public spaces for resistance and socio-cultural change. In doing so, this article sheds new light on the relationship between rural criminology and crime prevention policies in Southern Italy by demonstrating how community development practice of Libera Terra changes the meaning of landscape through iconographic symbolism and ethnographic performance

Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation

We compare the collider phenomenology of mirage mediation and deflected mirage mediation, which are two recently proposed "mixed" supersymmetry breaking scenarios motivated from string compactifications. The scenarios differ in that deflected mirage mediation includes contributions from gauge mediation in addition to the contributions from gravity mediation and anomaly mediation also present in mirage mediation. The threshold effects from gauge mediation can drastically alter the low energy spectrum from that of pure mirage mediation models, resulting in some cases in a squeezed gaugino spectrum and a gluino that is much lighter than other colored superpartners. We provide several benchmark deflected mirage mediation models and construct model lines as a function of the gauge mediation contributions, and discuss their discovery potential at the LHC.Comment: 29 pages, 9 figure

Atomic Scale Modelling of Two-Dimensional Molecular Self-Assembly on a Passivated Si Surface

International audienceThe self-assembly of two-dimensional (2D) molecular structures on a solid surface relies on the subtle balance between non covalent intermolecular and molecule-surface forces. The energetics of 2D molecular lattices forming different patterns on a passivated semiconductor surface are here investigated by a combination of atomistic simulation methods. Density-functional theory provides structure and charges of the molecules, while metadynamics with empirical forces provides a best guess for the lowest-energy adsorption sites of single molecules and dimers. Subsequently, molecular dynamics simulations of extended molecular assemblies with empirical forces yield the most favorable lattice structures at finite temperature and pressure.The theoretical results are in good agreement with scanning tunneling microscopy observations of self-assembled molecular monolayers on a B-doped Si(111) surface, thus allowing to rationalize the competition of long-range dispersion forces between the molecules and the surface. Such a result demonstrates the interest of this predictive approach for further progress in supramolecular chemistry on semiconductor surface

The Challenge of Development Control in Nigerian Capital Cities-A Case of Some Selected Cities in the Niger Delta

The astronomically increasing population and the spatial expansion of the primary cities in Nigeria necessitated the introduction of elements of development control in the country. This rapid population increase was occasioned by the economic and administrative roles which these cities played before and after independence in the country. These roles combined to trigger off rural-urban migration. The resulting situation was housing famine, haphazard spatial development, environmental chaos etc. in most parts of the cities. There became the need for the introduction of more stringent development control measures to prevent further environmental chaos. This step has resulted into the establishment of several physical planning laws to regulate physical development in the cities and major urban centres. Despite the existence of these laws over the years, most Nigerian cites are still far from being referred to as ‘world class’ cities. This has placed a serious question mark on the effectiveness of the development control mechanism in the country. In view of the question raised, this paper had taken a look at physical development control in some selected capital cities in the Niger Delta region of the country. In this regard questions were raised and directed at both the agencies in charge of development control and property developers in the study areas. It was discovered that inadequate funding, lack of equipment and machinery, lack of adequate public enlightenment, corruption on the part of planning officers, political interference etc. are some of the problems confronting effective development control in the capital cities. The findings had helped this paper to make appropriate recommendation as to how improvement can be made in the area of physical development and control in Nigerian cities. This paper is a product of intense days of field research that covered four cites in the Niger Delta. The information gathered from the field and the available literature from previous scholars on the subject matter made it possible to achieve the level of success recorded in this study. The use of structured questionnaire and direct observation technique made it possible to extract relevant information from our target population in this research. Face-to-Face discussion was also helpful in this research

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection. Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time. However, these experiments were performed before the recent discovery of more potent anti-HIV-1 antibodies and their improvement by structure-based design. Here we re-examine passive antibody transfer as a therapeutic modality in HIV-1-infected humanized mice. Although HIV-1 can escape from antibody monotherapy, combinations of broadly neutralizing antibodies can effectively control HIV-1 infection and suppress viral load to levels below detection. Moreover, in contrast to antiretroviral therapy the longer half-life of antibodies led to control of viraemia for an average of 60 days after cessation of therapy. Thus, combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV-1-infected individuals