Late Palaeozoic lithostratigraphy of the Andean Precordillera revisited (San Juan Province, Argentina)

New data on some neopalaeozoic lithostratigraphic units of the central sector of the Argentinean Precordillera are presented. The western Precordillera displays occasional outcrops of siliciclastic rocks of the Late Palaeozoic. These rocks are separated by two main unconformi­ties related to the development of the Chanic (Upper Devonian-early Carboniferous) and Gondwanan (late Carboniferous-early Permian) orogens. A major unconformity marks the beginning of the Andean cycle in middle Permian times. The Del Ratón Formation (800 m) in the studied area is made up of conglomerates and can be divided into two units. The basal part (Lower Member) was deposited in a fjord environment. The Upper Member was generated by an alluvial system that was mainly dominated by upper flow-regime plane beds, whereas its uppermost part accumulated in a fan delta setting. The clast provenance and the main palaeocurrents suggest the existence of a significant topographic high to the W and NW of the present outcrops. The El Planchón Formation (1400 m) is mainly composed of shales and sandstones as a result of sedimentation in a deep-sea fan environment. These lutite-dominated materials graded laterally north­wards into conglomerates in a glacial setting. The Del Ratón and El Planchón formations of the Lower Carboniferous correspond to the synorogenic Chanic sedimentation (Chanic foreland basin). Thereafter, the stratigraphic succession underwent deformation which led to its prolonged subaerial exposure and rubefaction. In Permian times, a marine transgression gave rise to the Del Salto Formation (600 m), which is constituted by beach deposits with some aeolian reworking and which lies unconformably over the Lower Carboniferous rocks. Conglomerates (Quebrada del Alumbre Formation, 100 m) produced by an alluvial system prograded episodically into coastal areas. The Escombrera Formation (350 m) is composed of beach deposits prograding seawards. This formation probably represents the end of the Palaeozoic sedimentary record. Thereafter, a playa-lake and an alluvial fan system were generated (Quebrada de la Arena Formation). This unit (750 m) was the last infill of the Gondwanan retroarc foreland, the total thickness of which was about 4000 m.Se presentan nuevos datos sobre las unidades neopaleozoicas aflorantes en la parte occidental de la Precordillera andina. Esas unidades litoestratigráficas estan separadas por dos discordancias angulares principales asociadas al desarrollo de las orogenias Chánica (Devónico tardío-Carbonífero temprano) y Gondwánica (Carbonífero tardío-Pérmico temprano) respectivamente. Otra nueva discordancia sugiere el inicio del ciclo andino durante el Pérmico medio. La Formación Del Ratón (800 m) está constituida principalmente por conglomerados y puede dividirse en dos unidades de rango menor: la parte basal y la parte superior respectivamente. La parte basal (Miembro inferior) fue acumulada en un fiordo. La parte superior (Miembro superior) fue generada en un sistema alluvial dominado predominantemente por la acumulación de capas planas de alto régimen de flujo, mientras que la parte más alta fue depositada en un entorno de abanico deltaico (fandelta). La procedencia de los clastos y las paleocorrientes principales indican la presencia de un relieve topográfico alto y significativo, situado al O y NO de los afloramientos actuales.La Formación El Planchón (1400 m) constituida principalmente por lutitas y areniscas fue acumulada en un contexto de abanico submarino (deep-sea fan). Estos materiales predominantemente lutíticos pasan lateralmente hacia el norte a conglomerados acumulados en un ambiente sedimentario glacial. Las Formaciones Del Ratón y El Planchón corresponden a la sedimentación sinorogénica Chánica (cuenca de antepaís chánica). Posteriormente, la sucesión estratigráfica sufrió una deformación que dió lugar a una prolongada exposición subaérea y su consiguiente rubefacción. Durante el Pérmico, una transgresión marina produjo la acumulación de la Formación Del Salto (600 m), que está constituída por depósitos de playa con algún retrabajamiento eólico y que recubre discordantemente los materiales del Carbonífero inferior. Un sistema aluvial conglomerático (Formación Quebrada del Alumbre 100 m) pogradó episódicamente sobre las zonas costeras. La Formación Escombrera (350 m), que está constituída por materiales arenosos coste-ros progradantes hacia el mar, representa, muy probablemente, el final del registro sedimentario paleozoico en esta zona. Posteriormente se generó otra discordancia sobre la que se acumularon materiales arenosos en un contexto de cursos fluviales trenzados sobre los que se disponen materiales lutíticos acumulados en una ciénaga (playa-lake) que gradan, primero a cursos trenzados, luego a cursos sinousos y finalmente a abanicos aluviales (Formación Quebrada de la Arena). Esta unidad (750 m) corresponde al último relleno sedimentario de la cuenca Gondwánica de retroarco, cuya potencia es del orden de unos 4000 m.Fil: Colombo, F.. Universidad de Barcelona; EspañaFil: Limarino, Carlos Oscar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología; ArgentinaFil: Spalletti, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Busquets, P. Universidad de Barcelona; EspañaFil: Cardo, R.. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; ArgentinaFil: Mendez Bedia, I. Universidad de Oviedo; EspañaFil: Heredia, N.. Instituto Geológico y Minero de España; Españ

Amphoteric polyamidoamines in the treatment of malaria

The present invention relates to the use of amphoteric polyamidoamines with MW of 10-100 kDa as antimalarial agents or carriers of antimalarial drugs and to formulations thereof

Erratum: “Seed layer technique for high quality epitaxial manganite films” [AIP Advances 6, 085109 (2016)]

No abstract available

On metastable configurations of small-world networks

We calculate the number of metastable configurations of Ising small-world networks which are constructed upon superimposing sparse Poisson random graphs onto a one-dimensional chain. Our solution is based on replicated transfer-matrix techniques. We examine the denegeracy of the ground state and we find a jump in the entropy of metastable configurations exactly at the crossover between the small-world and the Poisson random graph structures. We also examine the difference in entropy between metastable and all possible configurations, for both ferromagnetic and bond-disordered long-range couplings.Comment: 9 pages, 4 eps figure

Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus : studies in the pig model of influenza

Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 pandemic H1N1 (pH1N1) virus and three different European H1 swine influenza virus (SIV) lineages, and b) these H1 viruses and a European H3N2 SIV. Pigs were inoculated intranasally with representative strains of each virus lineage with 6- and 17-week intervals between H1 inoculations and between H1 and H3 inoculations, respectively. Virus titers in nasal swabs and/or tissues of the respiratory tract were determined after each inoculation. There was substantial though differing cross-protection between pH1N1 and other H1 viruses, which was directly correlated with the relatedness in the viral hemagglutinin (HA) and neuraminidase (NA) proteins. Cross-protection against H3N2 was almost complete in pigs with immunity against H1N2, but was weak in H1N1/pH1N1-immune pigs. In conclusion, infection with a live, wild type influenza virus may offer substantial cross-lineage protection against viruses of the same HA and/or NA subtype. True heterosubtypic protection, in contrast, appears to be minimal in natural influenza virus hosts. We discuss our findings in the light of the zoonotic and pandemic risks of SIVs

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

In memoriam of Andrés Pérez-Estaún

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Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans

Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches

In Memoriam. Andrés Pérez Estaún (1947-2014)

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