Commissioning of the Control System for the LHC Beam Dump Kicker System

The beam dumping system of the Large Hadron Collider (LHC) provides a loss-free fast extraction of the circulating beams. It consists per ring of 15 extraction kickers, followed by 15 septum magnets, 10 dilution kickers and an external absorber. A dump request can occur at any moment during the operation of the collider, from injection energy up to collision energy. All kickers must fire synchronously with the beam abort gap to properly extract the whole beam in one single turn into the extraction channel. Incorrect operation of the extraction kickers can lead to beam losses and severe damage to the machine. The control system of the LHC beam dump kickers is based on a modular architecture composed of 4 different sub-systems, each with a specific function, in order to detect internal failures, to ensure a correct extraction trajectory over the whole LHC operational range, to synchronise and distribute dumps requests, and to analyse the transient signals recorded during the beam dumping process. The control architecture is presented and the different steps performed for its validation, from the individual sub-systems tests to the final commissioning with beam, are describe

Conservation de la semence d'étalon pendant 72 heures aux températures de 4øC et 15øC: études in vitro et in vivo

National audienc

Truncating mutations on myofibrillar myopathies causing genes as prevalent molecular explanations on patients with dilated cardiomyopathy

International audienceDilated cardiomyopathy (DCM) is one of the leading causes of heart failure with high morbidity and mortality. More than 40 genes have been reported to cause DCM. To provide new insights into the pathophysiology of dilated cardiomyopathy, a next-generation sequencing (NGS) workflow based on a panel of 48 cardiomyopathies-causing genes was used to analyze a cohort of 222 DCM patients. Truncating variants were detected on 63 unrelated DCM cases (28.4%). Most of them were identified, as expected, on TTN (29 DCM probands), but truncating variants were also identified on myofibrillar myopathies causing genes in 17 DCM patients (7.7% of the DCM cohort): 10 variations on FLNC and 7 variations on BAG3. This study confirms that truncating variants on myofibrillar myopathies causing genes are frequently associated with dilated cardiomyopathies and also suggest that FLNC mutations could be considered as a common cause of dilated cardiomyopathy. Molecular approaches that would allow to detect systematically truncating variants in FLNC and BAG3 into genetic testing should significantly increase test sensitivity, thereby allowing earlier diagnosis and therapeutic intervention for many patients with dilated cardiomyopathy

Effect of storage and temperature on in vitro stallion sperm parameters and fertility rate

International audienc

MKI UFOs at Injection

During the MD, the production mechanism of UFOs at the injection kicker magnets (MKIs) was studied. This was done by pulsing the MKIs on a gap in the circulating beam, which led to an increased number of UFOs. In total 43 UFO type beam loss patterns at the MKIs were observed during the MD. The MD showed that pulsing the MKIs directly induces UFO type beam loss patterns. From the temporal characteristics of the loss profile, estimations about the dynamics of the UFOs are made