121 research outputs found
Primary structure and receptor-binding properties of a neurokinin A-related peptide from frog gut
Full text linkIn the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
Full text linkInvolvement of Pituitary Adenylate Cyclase-Activating Polypeptide in the Regulation of Frog Adrenal Steroidogenesisa
No full textLa pharmacologie inverse marque des points : découverte d'un nouveau peptide stimulant la sécrétion de prolactine.
No full textInfluence of an Alpha-1-Adrenoceptor Antagonist, Nicergoline, on Placental Prostanoid Production in Streptozotocin-Induced Diabetic Pregnant Rats
Full text linkThe aim of this study was to determine if placental prostanoids could mediate the vasodilating action of an alpha- 1-adrenoceptor antagonist, nicergoline (400 μg/kg i.p.), during late pregnancy in streptozotocin-induced diabetic rats (40 mg/kg i.v.). Placental prostanoid concentrations were evaluated by radioimmunoassay. Prostaglandin E<sub>2</sub> levels showed a highly significant increase in diabetic and nondiabetic rats treated with nicergoline (p < 0.001). 6-Keto-PGF<sub>1α</sub> concentrations were slightly increased in diabetic rats compared to controls, and this increase was reversed by both nicergoline and insulin treatments. In all groups studied thromboxane B<sub>2</sub> levels were comparable. It is concluded that prostaglandin E<sub>2</sub> could mediate the vasodilating action of nicergoline on the placental irrigation and, therefore, improved the hemodynamic state of this organ in diabetic rats.</jats:p
Le profil circadien du 26RFa dans l’anorexie mentale : nouvelle preuve d’une adaptation hormonale oréxigène face à la dénutrition
Full text linkSkin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.
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